利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.015 秒)

    PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    1.
    发明申请
    PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
    其含有苯并咪唑的苯并噻唑衍生物及其包含的药物组合物

    公开(公告)号：US20150011528A1

    公开(公告)日：2015-01-08

    申请号：US14346506

    申请日：2012-09-21

    申请人： YUHAN CORPORATION

    发明人： Youn Hur ,  Dong-Hyun Kim ,  Eun-Kyung Kim ,  Jin-Hwi Park ,  Jae-Eun Joo ,  Ho-Woong Kang ,  Se-Woong Oh ,  Dong-Kyun Kim ,  Kyoung-Kyu Ahn

    IPC分类号： C07D277/82 ,  C07D417/12 ,  C07D277/60 ,  C07D513/04

    CPC分类号： C07D277/82 ,  C07D277/60 ,  C07D417/12 ,  C07D513/04

    摘要： Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

    摘要翻译： 本发明提供含苯酰亚胺的苯并噻唑衍生物或其药学上可接受的盐，其制备方法和包含该方法的药物组合物。 含苯基酰亚胺的苯并噻唑衍生物或其药学上可接受的盐可以选择性地抑制KRS和层粘连蛋白受体（LR）之间的蛋白质 - 蛋白质相互作用，从而抑制癌细胞的迁移。 因此，含苯亚胺的苯并噻唑衍生物或其药学上可接受的盐可用于预防或治疗与癌细胞转移相关的疾病。