公开(公告)号：US10941136B2

公开(公告)日：2021-03-09

申请号：US16096712

申请日：2017-04-26

申请人： YUHAN CORPORATION

发明人： Young-Hwan Kim ,  Tae-Dong Han ,  Dong-Hoon Kim ,  Eun-Hye Jung ,  Su-Bin Choi ,  Eui-Chul Lee ,  Won-Ee Chong ,  Jin-Hwi Park ,  Jun-Chul Park ,  Ho-Woong Kang ,  Ji-Yeong Gal ,  Chan-Sun Park ,  Jong-Gyun Kim ,  Su-Youn Nam

IPC分类号： C07D239/91 ,  C07D403/14 ,  C07D217/24 ,  A61K31/51 ,  A61K31/506 ,  C07D403/12

摘要： The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.

公开(公告)号：US20190142809A1

公开(公告)日：2019-05-16

申请号：US16315814

申请日：2017-07-06

申请人： Yuhan Corporation

发明人： Se-Woong Oh ,  Youn Hur ,  Jin-Hwi Park ,  Jae-Eun Joo ,  Ho-Woong Kang ,  Hyok-Jun Cho ,  Eui-Chul Lee ,  Chan-Sun Park ,  Dong-Hyun Kim ,  Jong-Gyun Kim ,  Su-Youn Nam

IPC分类号： A61K31/428 ,  A61P35/04

CPC分类号： A61K31/428 ,  A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61P35/04 ,  C07D277/82

摘要： The present invention provides a benzo[d]thiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzo[d]thiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the benzo[d]thiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

公开(公告)号：US10383859B2

公开(公告)日：2019-08-20

申请号：US16315814

申请日：2017-07-06

申请人： Yuhan Corporation

发明人： Se-Woong Oh ,  Youn Hur ,  Jin-Hwi Park ,  Jae-Eun Joo ,  Ho-Woong Kang ,  Hyok-Jun Cho ,  Eui-Chul Lee ,  Chan-Sun Park ,  Dong-Hyun Kim ,  Jong-Gyun Kim ,  Su-Youn Nam

IPC分类号： C07D277/82 ,  A61K31/428 ,  A61P35/04

摘要： The present invention provides a benzo[d]thiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzo[d]thiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the benzo[d]thiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.