公开(公告)号：US12187714B2

公开(公告)日：2025-01-07

申请号：US18328267

申请日：2023-06-02

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Seong-Ran Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Dae-Gyu Park ,  Su-Min Park ,  Yoon-Ah Hwang

IPC: C07D413/14

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additionally, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US20220281861A1

公开(公告)日：2022-09-08

申请号：US17704718

申请日：2022-03-25

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Seong-Ran Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Dae-Gyu Park ,  Su-Min Park ,  Yoon-Ah Hwang

IPC: C07D413/14

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US11286253B2

公开(公告)日：2022-03-29

申请号：US17115037

申请日：2020-12-08

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Seong-Ran Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Dae-Gyu Park ,  Su-Min Park ,  Yoon-Ah Hwang

IPC: C07D413/14

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US11198684B2

公开(公告)日：2021-12-14

申请号：US16633756

申请日：2018-07-25

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Doo-Byung Lee ,  Jung-Ae Lee ,  Jun-Sup Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Sang-Seol Jeon

IPC: C07D265/30 ,  C07D295/135 ,  C07D403/04 ,  C07D413/14

Abstract: The present invention provides intermediates useful for the synthesis of an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors; and processes for preparing the same. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US10889578B2

公开(公告)日：2021-01-12

申请号：US16633684

申请日：2018-07-25

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Seong-Ran Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Dae-Gyu Park ,  Su-Min Park ,  Yoon-Ah Hwang

IPC: C07D413/14

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US12227478B2

公开(公告)日：2025-02-18

申请号：US17594062

申请日：2020-04-03

Applicant: YUHAN CORPORATION

Inventor： Sang-Ho Oh ,  Doo-Byung Lee ,  Kyoung-Chan Kwon ,  Sang-Won Kim ,  Hyo-Ick Hwang ,  Kyeong-Sill Lee ,  Ik-Su Jo ,  Ji-Hye Choi ,  Sung-Hee Cho ,  Su-Young Lee

IPC: C07D211/56 ,  C07D487/04

Abstract: Provided are a process for preparing (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine or a salt thereof, which is an intermediate useful for the preparation of tofacitinib, an intermediate used in the process, i.e., isopropanol solvate of methyl ((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)carbamate dibenzoyl-L-tartrate, an intermediate, having excellent stability, useful for the preparation of tofacitinib, i.e., (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine acetate, and a process for preparing tofacitinib or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11708362B2

公开(公告)日：2023-07-25

申请号：US17704718

申请日：2022-03-25

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Seong-Ran Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Dae-Gyu Park ,  Su-Min Park ,  Yoon-Ah Hwang

IPC: C07D413/14

CPC classification number: C07D413/14

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US20230312545A1

公开(公告)日：2023-10-05

申请号：US18328267

申请日：2023-06-02

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Seong-Ran Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Dae-Gyu Park ,  Su-Min Park ,  Yoon-Ah Hwang

IPC: C07D413/14

CPC classification number: C07D413/14

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additionally, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US20210269427A1

公开(公告)日：2021-09-02

申请号：US17115037

申请日：2020-12-08

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Seong-Ran Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Dae-Gyu Park ,  Su-Min Park ,  Yoon-Ah Hwang

IPC: C07D413/14

Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.

公开(公告)号：US10858353B2

公开(公告)日：2020-12-08

申请号：US16633695

申请日：2018-07-25

Applicant: Yuhan Corporation

Inventor： Sang-Ho Oh ,  Ja-Heouk Khoo ,  Jong-Chul Lim ,  Doo-Byung Lee ,  Jung-Ae Lee ,  Jun-Sup Lee ,  Hyun Ju ,  Woo-Seob Shin ,  Sang-Seol Jeon

IPC: C07D413/14 ,  C07D265/32 ,  C07D403/10

Abstract: The present invention provides a novel process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.