公开(公告)号：US20060019278A1

公开(公告)日：2006-01-26

申请号：US11144951

申请日：2005-06-03

申请人： Yuk Ming Lo ,  Rossa Chiu ,  Stephen Chim ,  Yu-kwan Tong ,  Chunming Ding

发明人： Yuk Ming Lo ,  Rossa Chiu ,  Stephen Chim ,  Yu-kwan Tong ,  Chunming Ding

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2521/331

摘要： The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.

摘要翻译： 本发明涉及通过分析存在于母亲血液中的胎儿DNA来诊断妊娠相关疾病的新方法。 更具体地说，本发明依赖于maspin基因在胎儿DNA和母体DNA中差异甲基化的发现，并提供了这些新的诊断方法，其将胎儿DNA与母体DNA区分开，并根据胎儿DNA水平和甲基化异常检测产前疾病 状态。

公开(公告)号：US20070275402A1

公开(公告)日：2007-11-29

申请号：US11784499

申请日：2007-04-06

申请人： Yuk Lo ,  Rossa Chiu ,  Stephen Chim ,  Chunming Ding ,  Shengnan Jin ,  Tracy Lee ,  Fiona Lun

发明人： Yuk Lo ,  Rossa Chiu ,  Stephen Chim ,  Chunming Ding ,  Shengnan Jin ,  Tracy Lee ,  Fiona Lun

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2523/125

摘要： This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.

摘要翻译： 该应用提供了新颖的胎儿标记物用于产前诊断和监测某些妊娠相关病症的用途。 更具体地，本发明在于发现位于胎儿染色体21上的某些CpG岛表现出与位于母体染色体21上的相应CpG岛不同的甲基化谱。该应用还提供用于诊断或监测相关 条件。