公开(公告)号：US06579860B1

公开(公告)日：2003-06-17

申请号：US09623014

申请日：2000-09-27

申请人： Junzo Koike ,  Yuriko Funaba ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

发明人： Junzo Koike ,  Yuriko Funaba ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

IPC分类号： A61K31663

CPC分类号： A61K31/663 ,  A61K31/675

摘要： An interleukin-6 production inhibitor is provided containing a methanebisphosphonic acid derivative as an active component, which has inhibitory effects on interleukin-6 production and is useful in prevention and treatment of diseases due to abnormal production of the interleukin-6. This pharmaceutical is anticipated to have effects in prevention and treatment of diseases related to the interleukin-6, for example, thrombocytosis, inflammatory diseases, abnormal immune response diseases, osteoporosis, rheumatoid arthritis, hypercalcemia, multiple myeloma, cachexia, and nephritis.

摘要翻译： 提供了含有作为活性成分的甲烷二膦酸衍生物的白细胞介素-6产生抑制剂，其对白细胞介素-6产生具有抑制作用，并且可用于预防和治疗由于白细胞介素-6异常产生引起的疾病。 预期该药物可预防和治疗与白细胞介素-6相关的疾病，例如血小板增多症，炎性疾病，异常免疫应答疾病，骨质疏松症，类风湿性关节炎，高钙血症，多发性骨髓瘤，恶病质和肾炎。

公开(公告)号：US06555529B1

公开(公告)日：2003-04-29

申请号：US09380090

申请日：1999-08-25

申请人： Yuriko Funaba ,  Junzo Koike ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

发明人： Yuriko Funaba ,  Junzo Koike ,  Masahiko Tanahashi ,  Seiji Okazaki ,  Masatoshi Ito

IPC分类号： A61K3166

CPC分类号： A61K31/66 ,  A61K31/663 ,  A61K31/675

摘要： The present invention has the objective of offering drug for treating abnormalities in bone marrow which corrects the biological balance in the bone marrow, in particular which has the effect of suppressing inflammatory cell infiltration and suppressing cell growth-differentiation factor increase. The present invention relates to drug for treating abnormalities in bone marrow which has, as an effective component, a methanebisphosphonic acid derivative, ester thereof, medicinally acceptable salt thereof, or a hydrate of these. The methanebisphosphonic acid derivatives of the present invention show an outstanding bone marrow abnormality therapeutic effect, so efficacy can be expected in the prevention and treatment of rheumatoid arthritis, multiple myeloma, osteomyelitis and other bone marrow abnormalities. Furthermore, application can also be expected in the prevention and treatment of hypoplastic anaemia, myelocytic leukaemia and other such haematopoietic disorders.

摘要翻译： 本发明的目的是提供一种用于治疗骨髓中异常的药物，其用于校正骨髓中的生物平衡，特别是其具有抑制炎性细胞浸润和抑制细胞生长分化因子增加的作用。本发明涉及 作为有效成分的甲烷二膦酸衍生物，其酯，药学上可接受的盐或其水合物的骨髓中异常的药物。本发明的甲烷二膦酸衍生物显示出优异的骨髓异常治疗效果 因此预防和治疗类风湿性关节炎，多发性骨髓瘤，骨髓炎等骨髓异常的疗效。 此外，还可以预期在预防和治疗发育不全的贫血，骨髓性白血病和其他这种造血障碍中的应用。