公开(公告)号：US20120172355A1

公开(公告)日：2012-07-05

申请号：US13417786

申请日：2012-03-12

申请人： Yuusuke TAMURA ,  Shinji SUZUKI ,  Yukio TADA ,  Shuji YONEZAWA ,  Chiaki FUJIKOSHI ,  Sae MATSUMOTO ,  Yuuji KOORIYAMA ,  Tatsuhiko UENO

发明人： Yuusuke TAMURA ,  Shinji SUZUKI ,  Yukio TADA ,  Shuji YONEZAWA ,  Chiaki FUJIKOSHI ,  Sae MATSUMOTO ,  Yuuji KOORIYAMA ,  Tatsuhiko UENO

IPC分类号： A61K31/541 ,  C07D417/12 ,  A61K31/54 ,  C07D279/06

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

摘要翻译： 本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R1是任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R2a和R2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R3a，R3b，R3c和R3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂合物，其可用于治疗由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病; 蛋白。

公开(公告)号：US20100081686A1

公开(公告)日：2010-04-01

申请号：US12585057

申请日：2009-09-02

申请人： Yukio TADA ,  Yasuyoshi ISO ,  Kohji HANASAKI

发明人： Yukio TADA ,  Yasuyoshi ISO ,  Kohji HANASAKI

IPC分类号： A61K31/4353 ,  C40B40/04 ,  C07D491/04 ,  A61P25/00

CPC分类号： C07D213/69 ,  C07D213/70 ,  C07D213/75 ,  C07D213/82 ,  C07D215/227 ,  C07D215/38 ,  C07D215/54 ,  C07D217/22 ,  C07D217/26 ,  C07D221/10 ,  C07D221/16 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D455/02 ,  C07D455/06 ,  C07D471/04 ,  C07D491/04

摘要： It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1—Y2—Y3—Ra wherein Y1 is single bond or the like; Y2 is —C(═O)—NH— or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.

摘要翻译： 发现对由式（I）表示的大麻素2型受体具有结合活性的化合物：其中R1是下式表示的基团-Y1-Y2-Y3-Ra，其中Y1是单键等 ; Y2是-C（= O）-NH-等; Y 3是任选取代的芳基等; R2是氢等; R3是烷基等; R4是烷基等; R5是任选取代的烷基等; 或R 3和R 4与相邻原子一起形成环状基团等。