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公开(公告)号：US4728729A
公开(公告)日：1988-03-01
申请号：US709647
申请日：1985-03-08
申请人： Yuzo Tarumi , Toshio Atsumi , Masaru Fukui
发明人： Yuzo Tarumi , Toshio Atsumi , Masaru Fukui
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61P35/00 , C07H19/052 , C07H19/067
CPC分类号： C07H19/052 , Y02P20/55
摘要： A novel cyanoimidazole nucleoside and derivative thereof, particularly 4-cyanoimidazolium-5-olate nucleoside and acyl derivatives thereof, and pharmaceutically acceptable salts thereof which are useful as antitumor agents and immunosuppressants, are prepared by dehydrating carboxamide derivatives of the formula: ##STR1## wherein R is an acyl group, and then, if desired, deacylating.
摘要翻译： 通过将下式的羧酰胺衍生物脱水制备，其可用作抗肿瘤剂和免疫抑制剂的新型氰基咪唑核苷及其衍生物，特别是4-氰基咪唑鎓-5-醇酸核苷及其酰基衍生物及其药学上可接受的盐，其中： R是酰基，然后，如果需要，进行脱酰基。
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公开(公告)号：US4318925A
公开(公告)日：1982-03-09
申请号：US132135
申请日：1980-03-20
IPC分类号： C07C235/14 , C07C67/00 , C07C231/00 , C07C231/12 , C07C235/22 , C07D209/48 , C07D295/088 , C07C103/37
CPC分类号： C07D209/48 , C07D295/088
摘要： A new class of 4-homoisotwistane derivatives of the formula, ##STR1## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and R.sub.2 is an alkyl group, a phenyl group which may be either unsubstituted or substituted with a C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, nitro group or a halogen atom (hereinafter referred to as "an optionally substituted phenyl group"), a group of the formula, --A--OH in which A is a C.sub.1 -C.sub.3 alkylene group; a group of the formula, --A--B in which A is as defined as above and B is a halogen atom, or a group of the formula, ##STR2## in which A is as defined above and R.sub.3 and R.sub.4 are independently a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group or R.sub.3 and R.sub.4 may, when taken together with the adjacent nitrogen atom to which R.sub.3 and R.sub.4 are linked, form pyrrolidine, piperidine, morpholine, phthalimide or piperazine, which have been found to possess potent antiviral activity, are prepared, for example by reacting a compound of the formula, ##STR3## wherein R.sub.1 is as defined above and X is halogen, with a compound of the formula,R.sub.5 OYwherein R.sub.5 has the same meanings as R.sub.2 with the exception of the group of the formula --A--B wherein A and B are as defined above and Y is alkali metal.
摘要翻译： 一种新的下式的4-异亮氨酸维生素衍生物，其中R1是氢原子或C1-C3烷基，R2是烷基，可以是未取代的或被C1- C3烷基，C1-C3烷氧基，硝基或卤素原子（以下称为“任选取代的苯基”），其中A为C1-C3亚烷基的式-A-OH基团; 其中A如上所定义并且B是卤素原子的式-AB，或其中A如上所定义的式（IMAGE）的基团，且R 3和R 4独立地是氢原子或 C1-C3烷基或R3和R4可以与R3和R4相连的相邻氮原子一起形成已被发现具有强抗病毒活性的吡咯烷，哌啶，吗啉，邻苯二甲酰亚胺或哌嗪，是 例如通过使下式的化合物，其中R 1如上所定义，X是卤素的化合物与下式化合物反应：其中R 5具有与R 2相同的含义， 式-AB其中A和B如上所定义，Y是碱金属。
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公开(公告)号：US4673668A
公开(公告)日：1987-06-16
申请号：US721606
申请日：1985-04-10
申请人： Kikuo Ishizumi , Naohito Ohashi , Norihiko Tanno , Hiromi Sato , Masaru Fukui , Shinya Morisada
发明人： Kikuo Ishizumi , Naohito Ohashi , Norihiko Tanno , Hiromi Sato , Masaru Fukui , Shinya Morisada
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P35/00 , C07D413/04 , C07H15/252 , A61K31/71 , C07H15/24
CPC分类号： C07D413/04 , C07H15/252
摘要： 9-Aminonaphthacene derivative having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are both hydrogen atoms or either one of them is a hydrogen atom and the other is hydroxy group or methoxy group; R.sup.3 is acetyl group or 1-hydroxyethyl group; R.sup.4 is a hydrogen atom; R.sup.5 is a hydrogen atom, hydroxy group, lower alkanoyloxy group, amino group, halogen-substituted lower alkanoylamino group or morpholino group; R.sup.6 is a hydrogen atom, hydroxy group, lower alkanoyloxy group or tetrahydropyranyloxy group; R.sup.7 is a hydrogen atom or methyl group; R is a hydrogen atom; and n is zero or one, which is useful as anti-cancer chemical agents with lower toxicity and with little local irritation and is able to orally be applied.
摘要翻译： 具有下式的9-氨基并萘系衍生物：其中R 1和R 2都是氢原子，或者它们之一是氢原子，另一个是羟基或甲氧基; R3是乙酰基或1-羟乙基; R4是氢原子; R5是氢原子，羟基，低级烷酰氧基，氨基，卤素取代的低级烷酰基氨基或吗啉代基; R6是氢原子，羟基，低级烷酰氧基或四氢吡喃氧基; R7是氢原子或甲基; R是氢原子; n为0或1，可用作毒性较小，局部刺激少的抗癌化学药剂，能够口服使用。
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公开(公告)号：US4174407A
公开(公告)日：1979-11-13
申请号：US869144
申请日：1978-01-13
申请人： Masaru Fukui , Shigeo Ogino , Hisao Yamamoto
发明人： Masaru Fukui , Shigeo Ogino , Hisao Yamamoto
IPC分类号： A61K31/13
CPC分类号： A61K31/13
摘要： Viral infections caused by viruses belonging to Herpes and Influenza groups can be controlled by administering an effective amount of 3-amino-4-homoisotwistane of the formula, ##STR1##
摘要翻译： 可以通过施用有效量的下式的3-氨基-4-异亮氨酸来控制属于疱疹和流感组的病毒引起的病毒感染
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公开(公告)号：US4230725A
公开(公告)日：1980-10-28
申请号：US939682
申请日：1978-09-05
申请人： Masaru Fukui , Shigeo Ogino , Hisao Yamamoto
发明人： Masaru Fukui , Shigeo Ogino , Hisao Yamamoto
IPC分类号： A61K31/13 , A61K31/135 , A61P31/12 , A61P31/22
CPC分类号： A61K31/13
摘要： Antiviral agents containing an effective amount of 1-amino-2,4-ethanobicyclo[3,3,1]nonane or salts thereof which are effective for the treatment or prevention of infectious diseases caused by herpes or influenza virus.
摘要翻译： 含有有效量的1-氨基-2,4-亚乙基双环[3,3,1]壬烷或其盐的抗病毒剂可有效治疗或预防由疱疹或流感病毒引起的传染病。
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公开(公告)号：US06850227B2
公开(公告)日：2005-02-01
申请号：US10278789
申请日：2002-10-24
CPC分类号： G06F3/0202 , G06F3/0231 , H01H2207/048 , H01H2239/01
摘要： In a wireless keyboard including an antenna wire for radiating a keyboard output signal from a transmitting section into the air and an electrode sheet secured in a keyboard casing and having an electrically conductive pattern coated thereon, the conductive pattern constituting a part of a switch which is turned on by depressing a key, the antenna wire is formed such that an electrically conductive pattern is coated on the electrode sheet in a manner similar to the electrically conductive pattern constituting a part of the switch. The antenna wire is formed at the same time as the electrically conductive pattern constituting a part of the switch and integrally with the electrode sheet.
摘要翻译： 在包括用于将发送部分的键盘输出信号发射到空气中的天线布线的无线键盘和固定在键盘壳体中并具有导电图案的电极板的导电图案构成开关的一部分 通过按下键来开启天线，使得导电图案以类似于构成开关的一部分的导电图案的方式涂覆在电极片上。 天线线与构成开关的一部分的导电图案同时形成，与电极片一体形成。
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