公开(公告)号：US20240316123A1

公开(公告)日：2024-09-26

申请号：US18616811

申请日：2024-03-26

申请人： ZBiotics Company

发明人： Zachary Abbott

IPC分类号： A61K35/742 ,  A61K9/00 ,  A61K35/00 ,  A61K35/741 ,  A61K38/00 ,  A61P39/02 ,  C07K14/32 ,  C12N9/02 ,  C12N15/63

CPC分类号： A61K35/742 ,  A61K9/0053 ,  A61P39/02 ,  C07K14/32 ,  C12N9/0008 ,  C12N15/63 ,  C12Y102/01003 ,  A61K9/0095 ,  A61K2035/115 ,  A61K35/741 ,  A61K38/00

摘要： Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

公开(公告)号：US11975033B2

公开(公告)日：2024-05-07

申请号：US17080185

申请日：2020-10-26

申请人： ZBiotics Company

发明人： Zachary Abbott

IPC分类号： A61K35/742 ,  A61K9/00 ,  A61P39/02 ,  C07K14/32 ,  C12N9/02 ,  C12N15/63 ,  A61K35/00 ,  A61K35/741 ,  A61K38/00

CPC分类号： A61K35/742 ,  A61K9/0053 ,  A61P39/02 ,  C07K14/32 ,  C12N9/0008 ,  C12N15/63 ,  C12Y102/01003 ,  A61K9/0095 ,  A61K2035/115 ,  A61K35/741 ,  A61K38/00

摘要： Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

公开(公告)号：US11696932B2

公开(公告)日：2023-07-11

申请号：US16646989

申请日：2018-09-13

申请人： ZBiotics Company

发明人： Zachary Abbott

IPC分类号： A61K35/742 ,  C12N15/63 ,  A61K35/741 ,  A61P39/02 ,  C12N9/02 ,  A61K9/00 ,  C07K14/32 ,  A61K35/00 ,  A61K38/00

CPC分类号： A61K35/742 ,  A61K9/0053 ,  A61P39/02 ,  C07K14/32 ,  C12N9/0008 ,  C12N15/63 ,  C12Y102/01003 ,  A61K9/0095 ,  A61K35/741 ,  A61K38/00 ,  A61K2035/115

摘要： Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

公开(公告)号：US20210121506A1

公开(公告)日：2021-04-29

申请号：US17080185

申请日：2020-10-26

申请人： ZBiotics Company

发明人： Zachary Abbott

IPC分类号： A61K35/742 ,  A61P39/02 ,  C12N9/02 ,  A61K9/00 ,  C12N15/63 ,  C07K14/32

摘要： Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.

公开(公告)号：US10849938B2

公开(公告)日：2020-12-01

申请号：US16048147

申请日：2018-07-27

申请人： ZBiotics Company

发明人： Zachary Abbott

IPC分类号： A61K35/741 ,  A61P39/02 ,  A61K35/742 ,  C12N9/02 ,  A61K9/00 ,  C12N15/63 ,  C07K14/32 ,  A61K35/00 ,  A61K38/00

摘要： Provided herein are recombinant microorganisms that express a subject polypeptide. Microorganisms can comprise an expression construct comprising a flagellin promoter operatively linked with a heterologous nucleotide sequence encoding the subject polypeptide. The flagellin promoter sequence can comprise a genetic modification that reduces CsrA inhibition of translation. Microorganisms also can comprise a genetic modification that reduces FlgM inhibition of SigD initiation of transcription. The target polypeptide can be an aldehyde dehydrogenase. Such microorganisms are useful in the treatment of alcohol hangover.