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1.
公开(公告)号:US09434763B2
公开(公告)日:2016-09-06
申请号:US14415374
申请日:2013-07-12
申请人: ZEDIRA GMBH
发明人: Christian Buchold , Uwe Gerlach , Martin Hils , Ralf Pasternack , Johannes Weber
IPC分类号: A61K45/06 , C07K5/093 , A61K38/07 , C07K1/06 , C07K5/113 , A61K38/06 , C07K5/10 , C07D213/75 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D493/10 , C07D401/06 , C07K5/02 , C07K5/083 , C07K5/117
CPC分类号: C07K5/1021 , A61K38/06 , A61K38/07 , A61K45/06 , C07D213/75 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D493/10 , C07K1/068 , C07K5/0202 , C07K5/081 , C07K5/0819 , C07K5/1002 , C07K5/1024
摘要: The invention relates to pyridinone derivatives of general formula (I) as inhibitors of tissue transglutaminase, to methods for producing the pyridinone derivatives, to pharmaceutical compositions containing said pyridinone derivatives and to their use for the prophylaxis and treatment of diseases associated with tissue transglutaminase.
摘要翻译: 本发明涉及作为组织转谷氨酰胺酶抑制剂的通式(I)的吡啶酮衍生物,制备吡啶酮衍生物的方法,含有所述吡啶酮衍生物的药物组合物及其用于预防和治疗与组织转谷氨酰胺酶有关的疾病的用途。
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2.
公开(公告)号:US20150203535A1
公开(公告)日:2015-07-23
申请号:US14415374
申请日:2013-07-12
申请人: ZEDIRA GMBH
发明人: Christian Buchold , Uwe Gerlach , Martin Hils , Ralf Pasternack , Johannes Weber
CPC分类号: C07K5/1021 , A61K38/06 , A61K38/07 , A61K45/06 , C07D213/75 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D493/10 , C07K1/068 , C07K5/0202 , C07K5/081 , C07K5/0819 , C07K5/1002 , C07K5/1024
摘要: The invention relates to pyridinone derivatives of general formula (I) as inhibitors of tissue transglutaminase, to methods for producing the pyridinone derivatives, to pharmaceutical compositions containing said pyridinone derivatives and to their use for the prophylaxis and treatment of diseases associated with tissue transglutaminase.
摘要翻译: 本发明涉及作为组织转谷氨酰胺酶抑制剂的通式(I)的吡啶酮衍生物,制备吡啶酮衍生物的方法,含有所述吡啶酮衍生物的药物组合物及其用于预防和治疗与组织转谷氨酰胺酶有关的疾病的用途。
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