公开(公告)号：US20020051805A1

公开(公告)日：2002-05-02

申请号：US09853746

申请日：2001-05-14

申请人： ZERIA PHARMACEUTICAL CO., LTD.

发明人： Shigeru Ueki ,  Yuko Hori ,  Yugo Matsunaga ,  Masaaki Nagasawa ,  Hiroyasu Nishioka ,  Masakazu Murata

IPC分类号： A61F013/00

CPC分类号： A61K31/426 ,  A61K31/381

摘要： Remedies effective for the improvement of colonic motor dysfunction such as irritable bowel syndrome, constipation or intestinal atony without causing side effects on the central nerve system. These colonic motor dysfunction remedies comprise, as active ingredients, aminothiazole derivatives represented by the following formula (I) or a salt or hydrate thereof: 1 wherein R1, R2 and R3 may be the same or different and each independently represent a hydrogen atom or a hydroxyl, lower alkyl, lower alkoxy, amino, nitro or cyano group, R4 and R5 may be the same or different and each independently represent a hydrogen atom or a lower alkyl group, and n stands for an integer of from 2 to 4.

摘要翻译： 治疗有助于改善结肠运动功能障碍，如肠易激综合征，便秘或肠痛，而不会对中枢神经系统造成副作用。 这些结肠运动障碍疗法包括作为活性成分的由下式（I）表示的氨基噻唑衍生物或其盐或水合物：其中R1，R2和R3可以相同或不同，并且各自独立地表示氢原子或羟基 ，低级烷基，低级烷氧基，氨基，硝基或氰基，R 4和R 5可以相同或不同，各自独立地表示氢原子或低级烷基，n表示2〜4的整数。