公开(公告)号：US20240190986A1

公开(公告)日：2024-06-13

申请号：US18269945

申请日：2021-12-27

申请人： Zhejiang Nanomab Technology Center Co. Ltd.

发明人： Jiaguo LI ,  Haixiang YU ,  Xiangzhen LIU ,  Weimin ZHU ,  Yan SUN ,  Na DING ,  Qijun QIAN

IPC分类号： C07K16/30 ,  G01N33/574

CPC分类号： C07K16/30 ,  G01N33/57484 ,  C07K2317/14 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/92

摘要： The present invention provides a mesothelin binding molecule, comprising an anti-mesothelin single domain antibody. Complementarity determining regions (CDR) of the single domain antibody comprise CDR1 shown in SEQ ID NO: 1, CDR2 shown in SEQ ID NO: 2, and CDR3 shown in SEQ ID NO: 3.

公开(公告)号：US20240174760A1

公开(公告)日：2024-05-30

申请号：US18552134

申请日：2022-03-22

申请人： ZHEJIANG NANOMAB TECHNOLOGY CENTER CO., LTD.

发明人： Bo PENG ,  Jiaguo LI ,  Haixiang YU ,  Xiangzhen LIU ,  Yan SUN ,  Weimin ZHU ,  Qijun QIAN

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  G01N33/574

CPC分类号： C07K16/2878 ,  A61P35/00 ,  G01N33/57492 ,  A61K39/00 ,  C07K2317/565 ,  C07K2317/569 ,  G01N2333/70575

摘要： Disclosed in the present invention is a nanobody, comprising a heavy chain variable region containing CDR1, CDR2 and/or CDR3, and having the function of recognizing and binding to BCMA. Reference can be made to the text for specific CDR sequences. Also disclosed in the present invention are a BCMA binding molecule, a composition comprising the nanobody or BCMA binding molecule, a BCMA detection agent, and an application of the nanobody, the BCMA binding molecule, or the composition in preparation of a drug for treating a BCMA related disease. The nanobody, BCMA binding molecule, and composition in the present invention can recognize and bind to BCMA, and have potential utility for treatment of BCMA related diseases.