公开(公告)号：US20240262891A1

公开(公告)日：2024-08-08

申请号：US17294414

申请日：2020-03-30

申请人： ZHEJIANG UNIVERSITY

发明人： Jiyoung ZHOU ,  Min LIAO ,  Yan YAN ,  Boli HU ,  Jinyan GU ,  Xiaojuan ZHENG ,  Weiren DONG ,  Yulan JIN

IPC分类号： C07K16/10 ,  G01N33/569

CPC分类号： C07K16/10 ,  G01N33/56983 ,  C07K2317/34 ,  G01N2333/145

摘要： The present invention discloses a hybridoma cell line for secreting monoclonal antibody against rabies virus M protein and application thereof, relates to the field of biotechnology. A classification of the hybridoma cell line is named as hybridoma cell line 4A1, and the hybridoma cell line was deposited on Apr. 1, 2019 in the China Center for Type Culture Collection, Wuhan University, Wuhan, China, with a deposit number CCTCC NO: C201947. The monoclonal antibody prepared by the hybridoma cell line has high titer, good specificity and excellent biological characteristics. The present invention identifies the variant antigen epitope recognized by the RABV M protein, the hybridoma cell line can be used to distinguish Flury strain and other RABV strains, prepare kit for detecting rabies virus RABV, detect RABV infection and differential diagnosis vaccine Flury strain and other RABV strains.