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1.发明授权Isolated strains of Staphylococcus aureus and vaccines manufactured therefrom 失效分离的金黄色葡萄球菌菌株和由其制备的疫苗公开(公告)号：US06544529B1
公开(公告)日：2003-04-08
申请号：US09582692
申请日：2000-09-01
IPC分类号： A61K39085
CPC分类号： C12R1/445 , A61K39/085
摘要： The invention provides antigenic compositions for the vaccination of an animal against bovine mastitis caused by infection with Staphylococcus aureus. The invention also provides methods for stimulating an animal's immune system to respond to antigens derived from selected strains of Staphylococcus aureus by administering the antigenic compositions of the invention to the animal.
摘要翻译： 本发明提供用于疫苗接种疫苗的抗原组合物，用于由金黄色葡萄球菌感染引起的牛乳腺炎。 本发明还提供了通过向动物施用本发明的抗原组合物来刺激动物免疫系统对衍生自选定的金黄色葡萄球菌菌株的抗原作出反应的方法。
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公开(公告)号：US10429389B2
公开(公告)日：2019-10-01
申请号：US14769030
申请日：2014-02-19
IPC分类号： G01N33/569 , G16H50/70 , G06F19/00
摘要： Methods of identifying altered leukocyte profiles are disclosed. In one embodiment, counts or relative percentages of leukocyte cell types are received and constitute input data points. Combinations of input data points are generated. Pairs of input data points and combinations are generated. Secondary data values are generated from the pairs. Three-dimensional plots are then constructed and selected as useful for identifying an altered leukocyte profile through pattern recognition of perpendicular data inflection, data bifurcation, non-overlapping data clusters, or combinations thereof. Such a strategy results in partially or totally non-overlapping data subsets, which are then interpreted.
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公开(公告)号：US20090186111A1
公开(公告)日：2009-07-23
申请号：US11658686
申请日：2005-07-24
摘要： A substance obtainable from Staphylococcus Aureus bacteria or from a Staphylococcus Aureus bacteria culture, the substance characterized in having at least one of the following characteristics: (a) stimulates proliferation of bovine T-lymphocytes in vitro; (b) accelerates healing of skin wounds in mice and pigs; (c) prevents AIDS-like disease (ALD) in mice infected with ALD virus (ALD-V) when injected substantially simultaneously with the virus; and (d) reduces the viral load in Rhesus Macaques infected with the hybrid simian/human immunodeficiency virus (SHIV) when injected into chronically infected Macaques, or a derivative or fraction of said substance which retains at least one of the characteristics of the substance. Also disclosed is a novel Staphylococcus Aureus bacteria, and a pharmaceutical composition comprising as active ingredient the substance and a pharmaceutically acceptable excipient.
摘要翻译： 一种从金黄色葡萄球菌或金黄色葡萄球菌培养物获得的物质，其特征在于具有以下特征中的至少一种：（a）在体外刺激牛T淋巴细胞的增殖; （b）加速小鼠和猪皮肤伤口愈合; （c）在与病毒基本上同时注射时，预防感染ALD病毒（ALD-V）的小鼠中的AIDS样疾病（ALD）; 和（d）当注射到慢性感染的猕猴中时，降低感染了混合猿猴/人类免疫缺陷病毒（SHIV）的恒河猴的病毒载量，或者所述物质的至少一种特征的衍生物或部分。 还公开了一种新型金黄色葡萄球菌，以及包含作为活性成分的物质和药学上可接受的赋形剂的药物组合物。
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公开(公告)号：US20160003821A1
公开(公告)日：2016-01-07
申请号：US14769030
申请日：2014-02-19
IPC分类号： G01N33/569
CPC分类号： G01N33/56972 , G16H50/70 , Y02A90/26
摘要： Methods of identifying altered leukocyte profiles are disclosed. In one embodiment, counts or relative percentages of leukocyte cell types are received and constitute input data points. Combinations of input data points are generated. Pairs of input data points and combinations are generated. Secondary data values are generated from the pairs. Three-dimensional plots are then constructed and selected as useful for identifying an altered leukocyte profile through pattern recognition of perpendicular data inflection, data bifurcation, non-overlapping data clusters, or combinations thereof. Such a strategy results in partially or totally non-overlapping data subsets, which are then interpreted.
摘要翻译： 公开了鉴定改变的白细胞分布的方法。 在一个实施方案中，接收白细胞细胞类型的计数或相对百分比并构成输入数据点。 生成输入数据点的组合。 生成一对输入数据点和组合。 从数据对中生成辅助数据值。 然后构建和选择三维图，用于通过垂直数据拐点，数据分岔，非重叠数据簇或其组合的图案识别来鉴定改变的白细胞分布。 这种策略导致部分或完全不重叠的数据子集，然后进行解释。
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