公开(公告)号：US09511101B2

公开(公告)日：2016-12-06

申请号：US14727487

申请日：2015-06-01

申请人： Immunology Laboratories, Inc.

发明人： Jiri Pillich ,  John C. Balcarek

IPC分类号： C12P1/04 ,  A61K39/085 ,  A61K35/741 ,  A61K39/09 ,  A61K39/12 ,  C12N7/00 ,  A61K39/02 ,  A61K39/108 ,  A61K39/104 ,  A61K9/00 ,  A61K39/00

CPC分类号： A61K39/085 ,  A61K9/0019 ,  A61K35/741 ,  A61K39/02 ,  A61K39/0266 ,  A61K39/092 ,  A61K39/104 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/58 ,  C12N7/00 ,  C12N2795/00011 ,  C12N2795/00034 ,  C12N2795/00071 ,  C12P1/04 ,  C12R1/22 ,  C12R1/385 ,  C12R1/445

摘要： The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of a protein isolated from bacterial lysate compositions for the treatment of pathological conditions of microbial infections. The present invention can also be used to enhance the immune system to prevent infections by the administration of an effective amount of the compositions.

公开(公告)号：US20100184160A1

公开(公告)日：2010-07-22

申请号：US12398821

申请日：2009-03-05

申请人： Chia Y. Lee ,  Thanh T. Luong

发明人： Chia Y. Lee ,  Thanh T. Luong

IPC分类号： C12P19/04 ,  C12N1/21 ,  C07H21/04

CPC分类号： C12P19/26 ,  C12N1/20 ,  C12N15/52 ,  C12N15/74 ,  C12R1/445

摘要： This disclosure presents embodiments of novel strains of Staphylococcus aureus that through genetic engineering produce type 5 capsular polysaccharide at greater levels than Staphylococcus aureus strain Reynolds.

摘要翻译： 本公开提供了金黄色葡萄球菌新菌株的实施方案，其通过遗传工程产生比金黄色葡萄球菌菌株雷诺数更高的5型荚膜多糖。

公开(公告)号：US20050238670A1

公开(公告)日：2005-10-27

申请号：US11170972

申请日：2005-06-30

申请人： Jiri Pillich ,  John Balcarek

发明人： Jiri Pillich ,  John Balcarek

IPC分类号： C12N1/20 ,  A01N63/00 ,  A61K35/74 ,  A61P9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P17/02 ,  A61P19/00 ,  A61P19/02 ,  A61P29/00 ,  A61P31/04 ,  A61P37/04 ,  C12N7/00 ,  C12N7/01 ,  C12P1/04 ,  C12R1/445 ,  A61K39/085

CPC分类号： A61K39/085 ,  A61K9/0019 ,  A61K35/741 ,  A61K39/02 ,  A61K39/0266 ,  A61K39/092 ,  A61K39/104 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/58 ,  C12N7/00 ,  C12N2795/00011 ,  C12N2795/00034 ,  C12N2795/00071 ,  C12P1/04 ,  C12R1/22 ,  C12R1/385 ,  C12R1/445

摘要： The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of bacterial lysate compositions for the treatment of pathological conditions of microbial infections. The present invention can also be used to enhance the immune system to prevent infections by the administration of an effective amount of the compositions.

摘要翻译： 本发明涉及用于治疗微生物感染和提高抗感染性的方法和组合物。 本发明包括施用有效量的细菌裂解物组合物用于治疗微生物感染的病理状况。 本发明还可用于增强免疫系统以通过施用有效量的组合物来预防感染。

公开(公告)号：US20030152594A1

公开(公告)日：2003-08-14

申请号：US10367213

申请日：2003-02-13

发明人： Jiri Pillich ,  John Balcarek

IPC分类号： A61K039/085 ,  A61K039/108 ,  C12N007/00

CPC分类号： A61K39/085 ,  A61K9/0019 ,  A61K35/741 ,  A61K39/02 ,  A61K39/0266 ,  A61K39/092 ,  A61K39/104 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/58 ,  C12N7/00 ,  C12N2795/00011 ,  C12N2795/00034 ,  C12N2795/00071 ,  C12P1/04 ,  C12R1/22 ,  C12R1/385 ,  C12R1/445

摘要： The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of bacterial lysate compositions for the treatment of pathological conditions of microbial infections. The present invention can also be used to enhance the immune system to prevent infections by the administration of an effective amount of the compositions.

摘要翻译： 本发明涉及用于治疗微生物感染和提高抗感染性的方法和组合物。 本发明包括施用有效量的细菌裂解物组合物用于治疗微生物感染的病理状况。 本发明还可用于增强免疫系统以通过施用有效量的组合物来预防感染。

公开(公告)号：US20020115190A1

公开(公告)日：2002-08-22

申请号：US10073681

申请日：2002-02-11

发明人： Juyu Chen

IPC分类号： C12N001/20 ,  C12N001/12 ,  C12N001/00

CPC分类号： C12R1/445 ,  A61K35/74 ,  C12N1/20

摘要： A method for preparing a culture of Staphylococcus aureus includes adding pork heart into water and smashing to obtain an extract of pork heart. Peptone and NaCl are then added to the extract to obtain a medium. A strain of S. aureus CGMCC 0485 is recovered and proliferated to obtain a seed solution. The seed solution is combined with the medium and then fermented to obtain a culture, the culture having an anticancer effect.

摘要翻译： 用于制备金黄色葡萄球菌培养物的方法包括将猪心脏加入水中并粉碎以获得猪心脏提取物。 然后将蛋白胨和NaCl加入到提取物中以获得培养基。 金黄色葡萄球菌CGMCC 0485的菌株被回收并增殖以获得种子溶液。 将种子溶液与培养基结合，然后发酵以获得培养物，培养物具有抗癌作用。

公开(公告)号：US4312942A

公开(公告)日：1982-01-26

申请号：US839846

申请日：1977-10-06

申请人： Hans-Georg Blobel ,  Werner Schaeg ,  Jorg Bruckler

发明人： Hans-Georg Blobel ,  Werner Schaeg ,  Jorg Bruckler

IPC分类号： G01N33/569 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/56 ,  G01N33/563 ,  G01N33/86 ,  C12N1/20 ,  C12R1/08

CPC分类号： C12R1/445 ,  C12Q1/56 ,  G01N33/563 ,  G01N2333/31 ,  G01N2333/75 ,  Y10S435/962 ,  Y10S435/963 ,  Y10S435/967 ,  Y10S436/828

摘要： There is provided a process for extraction of a microorganism, which comprises treating said microorganism with a 4 to 8 molar aqueous solution of a guanidine salt, subsequently washing it to liberate it from the salt and thus obtaining it and diagnostic agents containing a microorganism so extracted.

摘要翻译： 提供了一种微生物提取方法，其包括用4至8摩尔的胍盐水溶液处理所述微生物，随后将其洗涤以从盐中释放出来，从而获得其并含有如此提取的微生物的诊断剂 。

公开(公告)号：US20170368166A1

公开(公告)日：2017-12-28

申请号：US15684752

申请日：2017-08-23

申请人： Qu Biologics Inc.

发明人： Harold David Gunn

IPC分类号： A61K39/235 ,  A61K31/192 ,  A61K31/405 ,  A61K31/635 ,  A61K33/24 ,  A61K39/00 ,  A61K39/02 ,  A61K39/108 ,  A61K39/112 ,  A61K39/085 ,  A61K39/09 ,  A61K39/102 ,  A61K39/104 ,  A61K39/155 ,  A61K39/145 ,  G01N33/50 ,  C12R1/445

CPC分类号： A61K39/235 ,  A61K31/192 ,  A61K31/405 ,  A61K31/635 ,  A61K33/24 ,  A61K39/0011 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/0275 ,  A61K39/085 ,  A61K39/092 ,  A61K39/102 ,  A61K39/1045 ,  A61K39/145 ,  A61K39/155 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/585 ,  A61K2039/70 ,  C12N2710/10032 ,  C12N2760/16032 ,  C12N2760/18532 ,  C12N2760/18632 ,  C12R1/445 ,  G01N33/5055 ,  G01N33/5088 ,  Y02A50/474 ,  Y02A50/482 ,  A61K2300/00

摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated.

公开(公告)号：US09681666B2

公开(公告)日：2017-06-20

申请号：US15214685

申请日：2016-07-20

申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali

IPC分类号： A61K35/00 ,  A01N63/02 ,  C12N1/20 ,  C12R1/07 ,  A01N31/08 ,  A01N37/12 ,  C12R1/085 ,  C12R1/19 ,  C12R1/385 ,  C12R1/42 ,  C12R1/445 ,  C12R1/45 ,  C12R1/46

CPC分类号： A01N63/02 ,  A01N31/08 ,  A01N37/12 ,  C12N1/20 ,  C12R1/07 ,  C12R1/085 ,  C12R1/19 ,  C12R1/385 ,  C12R1/42 ,  C12R1/445 ,  C12R1/45 ,  C12R1/46 ,  A01N65/08

摘要： The antimicrobial effect of extracellular metabolite composition from Bacillus coagulans MTCC 5856 and composition comprising from about 61% w/w of thymol, about 38% of monolaurin and about 1% w/w of magnolol obtained from supercritical fluid extracts of Magnolia officinalis is described.

公开(公告)号：US20160324161A1

公开(公告)日：2016-11-10

申请号：US15214669

申请日：2016-07-20

申请人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sivakumar Arumugam ,  Furqan Ali

IPC分类号： A01N63/02 ,  C12R1/07

CPC分类号： A01N63/02 ,  A01N31/08 ,  A01N37/12 ,  C12N1/20 ,  C12R1/07 ,  C12R1/085 ,  C12R1/19 ,  C12R1/385 ,  C12R1/42 ,  C12R1/445 ,  C12R1/45 ,  C12R1/46 ,  A01N65/08

摘要： Disclosed is a method for producing partially purified extracellular metabolite preparation from the probiotic bacterial strain Bacillus coagulans SBC-37 (Deposited in the Microbial Type Culture Collection and Gene Bank as strain number MTCC 5856) exhibiting 99% genetic homology with the known bacterial strains Bacillus coagulans ATCC 31284, Bacillus coagulans NBRC 3887 and Bacillus coagulans ATCC 7050. Also disclosed is the anti-microbial profile of said extracellular metabolite preparation against a panel of microbial pathogens, including synergistic anti-microbial effects of preparation when combined with a synergistic preservative blend comprising from about 61% w/w of thymol, about 38% of monolaurin and about 1% w/w of magnolol obtained from supercritical fluid extracts of Magnolia officinalis. The extracellular metabolite preparation alone or the combination of said extracellular metabolite preparation and preservative blend also inhibits microbial biofilm formation in a synergistic manner.

公开(公告)号：US20160263209A1

公开(公告)日：2016-09-15

申请号：US15073441

申请日：2016-03-17

申请人： Qu Biologics Inc.

发明人： Harold David Gunn

IPC分类号： A61K39/235 ,  A61K39/108 ,  A61K39/09 ,  G01N33/50 ,  A61K39/02 ,  A61K39/102 ,  A61K39/145 ,  A61K39/155 ,  A61K33/24 ,  A61K39/104

CPC分类号： A61K39/235 ,  A61K31/192 ,  A61K31/405 ,  A61K31/635 ,  A61K33/24 ,  A61K39/0011 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/0275 ,  A61K39/085 ,  A61K39/092 ,  A61K39/102 ,  A61K39/1045 ,  A61K39/145 ,  A61K39/155 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/585 ,  A61K2039/70 ,  C12N2710/10032 ,  C12N2760/16032 ,  C12N2760/18532 ,  C12N2760/18632 ,  C12R1/445 ,  G01N33/5055 ,  G01N33/5088 ,  Y02A50/474 ,  Y02A50/482 ,  A61K2300/00

摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated.