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1.发明申请公开(公告)号：US20200306245A1
公开(公告)日：2020-10-01
申请号：US16647847
申请日：2017-09-20
发明人： Jinsheng LIN , Tianpei HUANG , Feifei LAN , Xiaoyan XU , Libin HU , Dan LI , Wenquan ZHU , Min LI , Zhiyun WANG
IPC分类号： A61K31/4965 , A61K47/38
摘要： Disclosed is N-formyl vortioxetine, and also disclosed is a method for preparing the N-formyl vortioxetine and a stable solid preparation of vortioxetine.
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公开(公告)号：US20190133953A1
公开(公告)日：2019-05-09
申请号：US16086592
申请日：2017-03-17
发明人： Xiangjie SHI , Jiening LIU , Xinshi WANG , Libin HU , Hao CHEN , Zhiyun WANG
IPC分类号： A61K9/19 , A61K9/00 , A61K31/706 , A61K47/10 , F26B5/06
摘要： Disclosed is a preparation method for an azacitidine for injection, wherein each injection vial of azacitidine for injection contains 100 mg of azacitidine and 100 mg of mannitol. The preparation method comprises the steps of measuring 80% of the total volume of water for injection at a temperature of 2-6° C.; adding mannitol, and stirring to completely dissolved at a temperature of 2-6° C.; adding azacitidine, stirring to completely dissolved at a temperature of 2-6° C. to obtain an azacitidine solution for injection; filling each injection vial with 23 ml azacitidine solution for injection after filtration; freeze-drying at a preset temperature; and stoppering, capping and packaging after nitrogen filling. The preparation method has the advantages of a simple process, low energy consumption, high production efficiency and stable product quality.
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公开(公告)号：US20220062249A1
公开(公告)日：2022-03-03
申请号：US17523229
申请日：2021-11-10
发明人： Jian GE , Yunfei LI , Lihong LIN , Dengxue SUN , Jiamiao WANG , Yijin WANG , Zhiyun WANG
摘要： A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals having an average particle size of 2-52 μm.
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