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1.发明申请公开(公告)号：US20180319828A1
公开(公告)日：2018-11-08
申请号：US15772521
申请日：2016-11-02
发明人： Siyuan Li , Shaoxiao Gui , Jicheng Zhang , Luning Huang , Anping Tao , Hong Gu
IPC分类号： C07F9/6558 , C07D413/14 , C07D401/04 , B01J27/122 , B01J27/055 , B01J31/02 , B01J31/30 , B01J31/28 , B01J31/22
CPC分类号： C07F9/65583 , B01J27/055 , B01J27/122 , B01J31/0212 , B01J31/0238 , B01J31/2295 , B01J31/28 , B01J31/30 , B01J2231/44 , B01J2531/824 , C07C213/00 , C07C217/40 , C07C217/48 , C07C231/10 , C07C235/78 , C07D263/20 , C07D263/24 , C07D401/04 , C07D413/14
摘要： The present invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, formula A, formula B, benzyl or benzyl substituted by a substituent, the substituent is selected from a group consisting of halogen, nitryl, C1-C6 alkyl, and C1-C6 alkoxy, and R1 is C1-C6 alkyl or C1-C6 alkyl substituted by halogen. The method comprises: generating a compound having a structure as shown in Formula C and a compound having a structure as shown in Formula D by a coupled reaction under the catalysis of a metal catalyst, a substituent of R being defined as above, where X is a leaving group, the leaving group comprising chlorine, bromine, iodine, and sulfonyl oxy such as trifluoromethane sulfonic oxy, methylsulfonyl oxy and benzenesulfonyl oxy, or benzenesulfonyl oxy substituted by one or more substituents, the substituent being selected from a group consisting of halogen, C1-C6 alkyl, and C1-C6 alkoxy.
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2.发明授权公开(公告)号：US10385079B2
公开(公告)日：2019-08-20
申请号：US15772521
申请日：2016-11-02
发明人： Siyuan Li , Shaoxiao Gui , Jicheng Zhang , Luning Huang , Anping Tao , Hong Gu
IPC分类号： C07D413/14 , C07F9/6558 , C07C213/00 , C07C217/48 , C07C231/10 , C07D263/20 , C07C235/78 , C07C217/40 , C07D263/24 , B01J27/055 , B01J27/122 , B01J31/02 , B01J31/22 , B01J31/28 , B01J31/30 , C07D401/04
摘要： The present invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, formula A, formula B, benzyl or benzyl substituted by a substituent, the substituent is selected from a group consisting of halogen, nitryl, C1-C6 alkyl, and C1-C6 alkoxy, and R1 is C1-C6 alkyl or C1-C6 alkyl substituted by halogen. The method comprises: generating a compound having a structure as shown in Formula C and a compound having a structure as shown in Formula D by a coupled reaction under the catalysis of a metal catalyst, a substituent of R being defined as above, where X is a leaving group, the leaving group comprising chlorine, bromine, iodine, and sulfonyl oxy such as trifluoromethane sulfonic oxy, methylsulfonyl oxy and benzenesulfonyl oxy, or benzenesulfonyl oxy substituted by one or more substituents, the substituent being selected from a group consisting of halogen, C1-C6 alkyl, and C1-C6 alkoxy.
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