METHODS FOR THE FORMATION OF HYDROGELS USING THIOSULFONATE COMPOSITIONS AND USES THEREOF
    1.
    发明申请
    METHODS FOR THE FORMATION OF HYDROGELS USING THIOSULFONATE COMPOSITIONS AND USES THEREOF 有权
    使用硫代磷酸酯组合物形成水凝胶的方法及其用途

    公开(公告)号:US20120289609A1

    公开(公告)日:2012-11-15

    申请号:US13554292

    申请日:2012-07-20

    IPC分类号: A61K47/34 A61P29/00

    摘要: The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.

    摘要翻译: 本发明提供了能够在暴露于水性环境中形成水凝胶的交联聚合物组合物和形成硫代磺酸盐的水凝胶组分的交联聚合物组合物。 本发明的硫代磺酸盐水凝胶形成成分优选为在不需要存在第二交联剂,氧化还原催化剂或辐射的情况下暴露于碱而形成交联聚合物组合物的多臂硫代磺酸盐聚合物衍生物。 还提供了形成水凝胶组合物的方法以及使用水凝胶的方法。