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1.发明申请SUBSTITUTED PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF 有权替代哌啶螺吡喃吡咯烷酮和哌啶酮，其制备和治疗用途公开(公告)号：US20120258979A1
公开(公告)日：2012-10-11
申请号：US13527147
申请日：2012-06-19
申请人： Zhongli GAO , Daniel HALL , Ryan HARTUNG
发明人： Zhongli GAO , Daniel HALL , Ryan HARTUNG
CPC分类号： C07D471/10
摘要： The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). wherein R1, R2, R3, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor are disclosed.
摘要翻译： 本公开涉及一系列式（I）的取代的N-苯基 - 联吡咯烷甲酰胺。 其中R1，R2，R3，m，n和p如本文所述。 更具体地，本发明的化合物是H3受体的调节剂，因此可用作药剂，特别是用于治疗和/或预防由H3受体调节的各种疾病，包括与中枢神经系统相关的疾病。 另外，公开了制备取代的N-苯基 - 联吡咯烷甲酰胺及其中间体的方法。
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2.发明申请SUBSTITUTED PIPERIDINE SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF 有权替代哌啶螺吡喃吡咯烷酮和哌啶酮，其制备和治疗用途公开(公告)号：US20110257213A1
公开(公告)日：2011-10-20
申请号：US13151946
申请日：2011-06-02
申请人： Zhongli GAO , Daniel HALL , Ryan HARTUNG
发明人： Zhongli GAO , Daniel HALL , Ryan HARTUNG
IPC分类号： A61K31/438 , A61P25/00 , A61P25/22 , A61P25/24 , A61P3/04 , C07D401/14 , A61P25/28
CPC分类号： C07D471/10
摘要： The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). wherein R1, R2, R3, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor are disclosed.
摘要翻译： 本公开涉及一系列式（I）的取代的N-苯基 - 联吡咯烷甲酰胺。 其中R1，R2，R3，m，n和p如本文所述。 更具体地，本发明的化合物是H3受体的调节剂，因此可用作药剂，特别是用于治疗和/或预防由H3受体调节的各种疾病，包括与中枢神经系统相关的疾病。 另外，公开了制备取代的N-苯基 - 联吡咯烷甲酰胺及其中间体的方法。
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