公开(公告)号：US20130189185A1

公开(公告)日：2013-07-25

申请号：US13549309

申请日：2012-07-13

申请人： Zibo LI ,  Francois P. GABBAI ,  Peter S. CONTI ,  Todd W. HUDNALL ,  Tzu-Pin LIN ,  Shuanglong LIU ,  Chiun-Wei HUANG

发明人： Zibo LI ,  Francois P. GABBAI ,  Peter S. CONTI ,  Todd W. HUDNALL ,  Tzu-Pin LIN ,  Shuanglong LIU ,  Chiun-Wei HUANG

IPC分类号： A61K51/04 ,  C07F5/02

CPC分类号： A61K51/0446 ,  A61K49/0002 ,  A61K49/0021 ,  A61K51/00 ,  A61K51/0423 ,  A61K51/0455 ,  C07F5/022

摘要： A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.

摘要翻译： 用作PET和/或荧光成像探针的组合物，式I化合物，包括其盐，水合物和溶剂合物：其中R 1 -R 7可以独立地选自氢，卤素，羟基，烷氧基，硝基，取代和未取代的 氨基，环烷基，羧基，羧酸及其酯，氰基，卤代烷基，芳基，X选自C和N; 并且A选自氢，卤素，羟基，烷氧基，硝基，取代和未取代的氨基，烷基，环烷基，羧基，羧酸及其酯，氰基，卤代烷基，芳基，包括苯基和氨基苯基，以及杂芳基。