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公开(公告)号：US20240174608A1
公开(公告)日：2024-05-30
申请号：US18279162
申请日：2022-03-11
发明人： Changning Wang , Yulong Xu , Can Zhang , Rudolph E. Tanzi
IPC分类号： C07D209/88 , A61K51/04 , C07B59/00
CPC分类号： C07D209/88 , A61K51/0446 , C07B59/002 , A61K2123/00 , C07B2200/05
摘要： The present application provides radiolabeled tetrahydrocarbazole compounds that can be used as positron emission tomography imaging probes. Pharmaceutical compositions and methods of using these compounds for diagnosis and monitoring treatment of neurodegenerative diseases (such as Alzheimer's disease) are also provided.
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公开(公告)号：US20240002376A1
公开(公告)日：2024-01-04
申请号：US18022708
申请日：2021-08-23
申请人： City of Hope
发明人： Fouad Kandeel , Junfeng Li , Jiangling Peng
IPC分类号： C07D471/04 , A61K51/04
CPC分类号： C07D471/04 , A61K51/0446
摘要： Disclosed herein, inter alia, are compounds and methods for G-protein-coupled receptor 44 detection.
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公开(公告)号：US20230348405A1
公开(公告)日：2023-11-02
申请号：US18052804
申请日：2022-11-04
发明人： Martin G. Pomper , Ronnie C. Mease , Ying Chen , Sangeeta Ray
IPC分类号： C07D257/02 , C07D209/14 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/82 , A61K49/00 , C07D209/24 , A61K51/04 , C07D209/12 , C07D311/20 , C07F5/02 , C07F13/00 , G01N33/50
CPC分类号： C07D257/02 , C07D209/14 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/82 , A61K49/0032 , C07D209/24 , A61K49/0052 , A61K51/0421 , A61K51/044 , A61K51/0446 , A61K51/0453 , A61K51/0472 , C07D209/12 , C07D311/20 , C07F5/027 , C07F13/005 , G01N33/5091 , G01N2800/342 , A61P35/00
摘要： Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
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公开(公告)号：US11661402B2
公开(公告)日：2023-05-30
申请号：US17718812
申请日：2022-04-12
发明人： Martin G. Pomper , Ronnie C. Mease , Ying Chen , Sangeeta Ray
IPC分类号： A61K51/00 , A61M36/14 , C07D257/02 , C07D209/14 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/82 , A61K49/00 , C07D209/24 , A61K51/04 , C07D209/12 , C07D311/20 , C07F5/02 , C07F13/00 , G01N33/50 , A61P35/00
CPC分类号： C07D257/02 , A61K49/0032 , A61K49/0052 , A61K51/044 , A61K51/0421 , A61K51/0446 , A61K51/0453 , A61K51/0472 , C07D209/12 , C07D209/14 , C07D209/24 , C07D213/04 , C07D249/04 , C07D255/02 , C07D311/14 , C07D311/20 , C07D311/82 , C07F5/027 , C07F13/005 , G01N33/5091 , A61P35/00 , G01N2800/342
摘要： Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
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公开(公告)号：US10005793B2
公开(公告)日：2018-06-26
申请号：US14432567
申请日：2013-10-01
IPC分类号： C07F5/02 , C07D257/08 , G01N33/534 , A61K51/04
CPC分类号： C07F5/02 , A61K51/0446 , C07D257/08 , C07F5/025 , G01N33/534
摘要： This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are compounds of Formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein: (a) is a BODIPY ligand system; X is a halogen; L is absent or a linker; and Z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent.
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公开(公告)号：US09649392B2
公开(公告)日：2017-05-16
申请号：US14146508
申请日：2014-01-02
发明人： Tsuyoshi Nomoto , Kohei Watanabe , Taichi Shintou , Takeshi Miyazaki , Toshio Tanaka , Yuhei Nishimura , Yasuhito Shimada
CPC分类号： A61K49/0004 , A61K49/0032 , A61K49/0041 , A61K51/0446
摘要： There is provided a central nervous system labelling composition for intranasal administration for the purpose of labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration. Additionally, there is provided a method of non-invasively labelling the central nervous system by way of an administration route that entails little transferability to the entire body. Furthermore, there is provided a screening method using a central nervous system labelling composition for intranasal administration. A central nervous system labelling composition for intranasal administration is characterized by labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration and by containing at least one compound expressed either by the general formula (1) or the general formula (2) shown below as effective component:
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7.发明申请公开(公告)号：US20170015640A1
公开(公告)日：2017-01-19
申请号：US15123686
申请日：2015-03-04
发明人： Simona COLLINA , Daniela ROSSI , Annamaria MARRA , Marco PEVIANI , Daniela CURTI
IPC分类号： C07D295/092 , C07C215/20 , A61K51/04 , C07D279/12 , C07D207/325 , C07D295/096 , C07C217/64
CPC分类号： C07D295/092 , A61K31/137 , A61K31/40 , A61K31/4174 , A61K31/4453 , A61K31/495 , A61K31/5375 , A61K31/54 , A61K51/04 , A61K51/0446 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0463 , A61K51/0465 , C07C215/20 , C07C217/64 , C07D207/325 , C07D279/12 , C07D295/096 , G01N33/57415
摘要： The present invention relates to the use of arylalkanolamine compounds with sigma-1 receptor antagonist activity. In particular, the said arylalkanolamine compounds are useful in the treatment of conditions selected from the abuse of psychotropic substances such as cocaine or amphetamines, pain and cancer.
摘要翻译： 本发明涉及具有σ-1受体拮抗剂活性的芳基烷醇胺化合物的用途。 特别地，所述芳基烷醇胺化合物可用于治疗选自滥用精神药物如可卡因或苯丙胺，疼痛和癌症的病症。
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8.发明授权Radiolabeled inhibitors of the amino acid transporters ASCT1 and ASCT2 有权氨基酸转运蛋白ASCT1和ASCT2的放射性标记抑制剂公开(公告)号：US09512074B2
公开(公告)日：2016-12-06
申请号：US14515103
申请日：2014-10-15
IPC分类号： A61K51/04 , C07D207/16 , C07B59/00
CPC分类号： C07D207/16 , A61K51/0446 , C07B59/002
摘要： The present invention relates to a compound of Formula (I) or (II) or a salt thereof, wherein R is described herein. The compounds are novel hydroxy-proline analog inhibitors of the ASCT1 and ASCT2 neutral amino acid transporters.
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公开(公告)号：US09492571B2
公开(公告)日：2016-11-15
申请号：US14400757
申请日：2013-05-27
发明人： Brian D. Gray , Mary Rusckowski , Koon Y. Pak
IPC分类号： A61K51/04 , A61K49/00 , C07D209/14 , C07B59/00 , C07D209/20 , C07D403/14 , G01N33/50 , G01N33/58
CPC分类号： A61K51/0485 , A61K49/0032 , A61K51/0446 , A61K51/0478 , A61K51/0482 , C07B59/002 , C07D209/14 , C07D209/20 , C07D403/14 , G01N33/5005 , G01N33/52 , G01N33/56966 , G01N33/582
摘要： The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes of the invention are constructed, for example, by utilizing (a) the high selectivity of long hydrocarbon chains for binding to plasma membranes of cells, (b) a near-infrared (NIR) dye for optical imaging, and (c) a radionuclide for PET or SPECT imaging. The in vitro and in vivo data of the optical and radiolabeled probes demonstrated their utility for detecting the presence of stem cells with multiple imaging modalities.
摘要翻译： 本发明涉及用于成像，跟踪和分析干细胞和相关生物样品的新型多模态探针及其制备和使用方法。 本发明的分子探针例如通过利用（a）长烃链的高选择性结合细胞质膜，（b）用于光学成像的近红外（NIR）染料和（c ）用于PET或SPECT成像的放射性核素。 光学和放射性标记的探针的体外和体内数据证明了它们用于以多种成像方式检测干细胞的存在。
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10.发明申请公开(公告)号：US20160222036A1
公开(公告)日：2016-08-04
申请号：US14610417
申请日：2015-01-30
发明人： John W. BABICH , Craig Zimmerman , John Joyal , Kevin P. Maresca , John Marquis , Genliang Lu , Jian-cheng Wang , Shawn Hillier
CPC分类号： A61K31/18 , A61K31/4192 , A61K31/444 , A61K31/555 , A61K47/22 , A61K49/00 , A61K51/04 , A61K51/0406 , A61K51/041 , A61K51/0446 , A61K51/0474 , A61K51/0478 , C07C275/16 , C07C311/16 , C07D213/38 , C07D403/06 , C07D403/12 , C07F13/005
摘要： A method of imaging a region in a subject includes administering to the subject a complex of a metal chelated to a compound, and obtaining an image of the region in the subject.
摘要翻译： 对受试者中的区域成像的方法包括向受试者施用与化合物螯合的金属的复合物，并获得受试者中的区域的图像。
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