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1.发明申请Method of immunizing humans against salmonella typhi using a Vi-rEPA conjugate vaccine 失效使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法公开(公告)号：US20070172501A1
公开(公告)日：2007-07-26
申请号：US11726304
申请日：2007-03-20
IPC分类号： A61K39/112 , C07K14/21
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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2.发明授权Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine 失效使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法公开(公告)号：US07754227B2
公开(公告)日：2010-07-13
申请号：US11726304
申请日：2007-03-20
IPC分类号： A61K39/112
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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3.发明授权Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine 有权使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法公开(公告)号：US08202520B2
公开(公告)日：2012-06-19
申请号：US12790258
申请日：2010-05-28
IPC分类号： A61K39/385
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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4.发明申请METHOD OF IMMUNIZING HUMANS AGAINST SALMONELLA TYPHI USING A VI-REPA CONJUGATE VACCINE 有权使用维生素C联合疫苗免疫沙门氏菌的人类免疫方法公开(公告)号：US20100239601A1
公开(公告)日：2010-09-23
申请号：US12790258
申请日：2010-05-28
IPC分类号： A61K39/385 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/6037 , A61K2039/6068 , A61K2039/627 , C07K14/21 , C07K14/255 , Y02A50/482 , Y02A50/484
摘要： This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
摘要翻译： 本发明涉及伤寒沙门氏菌的Vi多糖与载体铜绿假单胞菌重组外蛋白A（rEPA）的缀合物及其组合物，以及这些缀合物和/或其组合物用于在人体中诱导免疫原性应答的方法， 包括提供防治或减轻伤寒沙门菌细菌感染严重性的反应。 缀合物及其组合物可用作诱导针对伤寒沙雷氏菌的血清抗体的疫苗，并且可用于预防和/或治疗由伤寒沙门氏菌引起的疾病。
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5.发明申请Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli 有权用于引发针对杆菌的免疫应答的聚-γ-谷氨酸缀合物公开(公告)号：US20060134143A1
公开(公告)日：2006-06-22
申请号：US10559825
申请日：2004-06-04
申请人： Rachel Schneerson , Stephen Leppla , John Robbins , Joseph Shiloach , Joanna Kubler-Kielb , Darrell Liu , Fathy Majadly
发明人： Rachel Schneerson , Stephen Leppla , John Robbins , Joseph Shiloach , Joanna Kubler-Kielb , Darrell Liu , Fathy Majadly
CPC分类号： C07K14/32 , A61K39/00 , A61K39/07 , A61K47/646 , A61K2039/55516 , A61K2039/6031 , A61K2039/6037 , A61K2039/627
摘要： Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-γ-glutamic acid (γPGA) polypeptide of B. anthracis, or of another Bacillus that expresses a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered.
摘要翻译： 提供用于引发针对炭疽杆菌和其他杆菌的免疫应答的免疫原性组合物和方法，其包括炭疽杆菌的多聚-γ-谷氨酸（γPGA）多肽或表达γPGA多肽的另一种芽孢杆菌的免疫原性缀合物。 在施用共轭物的哺乳动物宿主中，γPGA偶联物引发针对炭疽杆菌或针对另一种芽孢杆菌的有效免疫应答。
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公开(公告)号：US20100040644A1
公开(公告)日：2010-02-18
申请号：US12582420
申请日：2009-10-20
申请人： Rachel Schneerson , Joanna Kubler-Kielb , Fathy Majadly , Stephen H. Leppla , John B. Robbins , Darrell T. Liu , Joseph Shiloach
发明人： Rachel Schneerson , Joanna Kubler-Kielb , Fathy Majadly , Stephen H. Leppla , John B. Robbins , Darrell T. Liu , Joseph Shiloach
IPC分类号： A61K39/385 , C07K17/00 , A61P37/04
CPC分类号： C07K14/32 , A61K39/385 , A61K2039/6031 , A61K2039/6037 , A61K2039/627
摘要： Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazine-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.
摘要翻译： 制备免疫原性缀合物的方法，其包括与载体共价连接的半抗原或抗原。 所述方法包括使第一试剂与二酰肼反应，得到肼修饰的第一试剂，其中第一试剂是半抗原，抗原或载体; 使第二试剂与苯甲醛化合物反应，得到苯甲醛修饰的第二试剂，其中第二试剂是半抗原，抗原或载体，条件是第一试剂或第二试剂是载体; 并使肼修饰的第一试剂与苯甲醛修饰的第二试剂反应，得到包含通过腙键与载体共价连接的半抗原或抗原的免疫原性缀合物。
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7.发明授权Recombinant modified Bacillus anthracis protective antigen for use in vaccines 有权用于疫苗的重组改良的炭疽芽孢杆菌保护性抗原公开(公告)号：US08394387B1
公开(公告)日：2013-03-12
申请号：US11831860
申请日：2007-07-31
申请人： Stephen H. Leppla , Mary Jo Rosovitz , John B. Robbins , Rachel Schneerson , S. Dana Hsu , Joseph Shiloach , Delia M. Ramirez
发明人： Stephen H. Leppla , Mary Jo Rosovitz , John B. Robbins , Rachel Schneerson , S. Dana Hsu , Joseph Shiloach , Delia M. Ramirez
CPC分类号： C07K14/32 , A61K39/00 , A61K2039/505 , A61K2039/53
摘要： The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译： 本发明涉及生产和回收孢子形成缺陷型炭疽芽孢杆菌突变体染色体的改进方法，以及用于生产和回收重组炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA以及使用这些PA的方法 或编码这些PA的核酸在人中引发免疫原性应答，包括提供针对或降低炭疽杆菌细菌感染的严重性的反应，并且其可用于预防和/或治疗由炭疽杆菌引起的疾病，例如 作为吸入性炭疽，皮肤炭疽和胃肠道炭疽。
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8.发明申请RECOMBINANT MODIFIED BACILLUS ANTHRACIS PROTECTIVE ANTIGEN FOR USE IN VACCINES 有权用于疫苗的重组改性的BACILLUS ANTHRACIS保护性抗原公开(公告)号：US20130058967A1
公开(公告)日：2013-03-07
申请号：US11831860
申请日：2007-07-31
申请人： Stephen H. Leppla , Mary Jo Rosovitz , John B. Robbins , Rachel Schneerson , S. Dana Hsu , Joseph Shiloach , Delia M. Ramirez
发明人： Stephen H. Leppla , Mary Jo Rosovitz , John B. Robbins , Rachel Schneerson , S. Dana Hsu , Joseph Shiloach , Delia M. Ramirez
CPC分类号： C07K14/32 , A61K39/00 , A61K2039/505 , A61K2039/53
摘要： The invention relates to improved methods of producing and recovering sporulation-deficient B. anthracis mutant stains, and for producing and recovering recombinant B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
摘要翻译： 本发明涉及生产和回收孢子形成缺陷型炭疽芽孢杆菌突变体染色体的改进方法，以及用于生产和回收重组炭疽芽孢杆菌保护性抗原（PA），特别是蛋白酶抗性的经修饰的PA以及使用这些PA的方法 或编码这些PA的核酸在人中引发免疫原性应答，包括提供针对或降低炭疽杆菌细菌感染的严重性的反应，并且其可用于预防和/或治疗由炭疽杆菌引起的疾病，例如 作为吸入性炭疽，皮肤炭疽和胃肠道炭疽。
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公开(公告)号：US08481048B2
公开(公告)日：2013-07-09
申请号：US12582420
申请日：2009-10-20
申请人： Rachel Schneerson , Joanna Kubler-Kielb , Fathy Majadly , Stephen H. Leppla , John B. Robbins , Darrell T. Liu , Joseph Shiloach
发明人： Rachel Schneerson , Joanna Kubler-Kielb , Fathy Majadly , Stephen H. Leppla , John B. Robbins , Darrell T. Liu , Joseph Shiloach
IPC分类号： A61K39/385 , C07K17/00 , A61P37/04
CPC分类号： C07K14/32 , A61K39/385 , A61K2039/6031 , A61K2039/6037 , A61K2039/627
摘要： Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazine-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.
摘要翻译： 制备免疫原性缀合物的方法，其包括与载体共价连接的半抗原或抗原。 所述方法包括使第一试剂与二酰肼反应，得到肼修饰的第一试剂，其中第一试剂是半抗原，抗原或载体; 使第二试剂与苯甲醛化合物反应，得到苯甲醛修饰的第二试剂，其中第二试剂是半抗原，抗原或载体，条件是第一试剂或第二试剂是载体; 并使肼修饰的第一试剂与苯甲醛修饰的第二试剂反应，得到包含通过腙键与载体共价连接的半抗原或抗原的免疫原性缀合物。
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10.发明授权Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli 有权用于引发针对杆菌的免疫应答的聚-γ-谷氨酸缀合物公开(公告)号：US07803386B2
公开(公告)日：2010-09-28
申请号：US10559825
申请日：2004-06-04
申请人： Rachel Schneerson , Stephen Leppla , John B. Robbins , Joseph Shiloach , Joanna Kubler-Kielb , Darrell Liu , Fathy Majadly
发明人： Rachel Schneerson , Stephen Leppla , John B. Robbins , Joseph Shiloach , Joanna Kubler-Kielb , Darrell Liu , Fathy Majadly
CPC分类号： C07K14/32 , A61K39/00 , A61K39/07 , A61K47/646 , A61K2039/55516 , A61K2039/6031 , A61K2039/6037 , A61K2039/627
摘要： Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-γ-glutamic acid (γPGA) polypeptide of B. anthracis, or of another Bacillus that expresses a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered.
摘要翻译： 提供了引发针对炭疽杆菌和其他杆菌的免疫应答的免疫原性组合物和方法，其包括炭疽芽孢杆菌的多聚-γ-谷氨酸（γPGA）多肽或表达γPGA多肽的另一种芽孢杆菌的免疫原性缀合物。 γPGA偶联物在给予缀合物的哺乳动物宿主中引发针对炭疽杆菌或针对另一种芽孢杆菌的有效免疫应答。
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