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公开(公告)号：US20190248897A1
公开(公告)日：2019-08-15
申请号：US16256824
申请日：2019-01-24
申请人： Zymeworks Inc.
CPC分类号： C07K16/2809 , C07K16/2803 , C07K16/2887 , C07K16/32 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer constructs are based on a heterodimeric Fc scaffold or on a segmented albumin scaffold. Also disclosed herein are multi-specific heteromultimer constructs that bind to HER2 and HER3.
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公开(公告)号：US20180179295A1
公开(公告)日：2018-06-28
申请号：US15863464
申请日：2018-01-05
申请人： Zymeworks Inc.
发明人： Nina E. Weisser , Gordon Yiu Kon Ng , Grant Raymond Wickman , Surjit Bhimarao Dixit , Eric Escobar-Cabrera , Mario Sanches
IPC分类号： C07K16/32 , A61K47/68 , A61K39/395 , A61K45/06 , C07K16/30 , G01N33/574
CPC分类号： C07K16/32 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57492
摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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公开(公告)号：US10000576B1
公开(公告)日：2018-06-19
申请号：US15863464
申请日：2018-01-05
申请人： Zymeworks Inc.
发明人： Nina E. Weisser , Gordon Yiu Kon Ng , Grant Raymond Wickman , Surjit Bhimarao Dixit , Eric Escobar-Cabrera , Mario Sanches
IPC分类号： A61K39/395 , C07K16/32 , A61K47/68 , A61K45/06 , C07K16/30 , G01N33/574 , A61K39/00
摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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公开(公告)号：US11325981B2
公开(公告)日：2022-05-10
申请号：US16011048
申请日：2018-06-18
申请人： Zymeworks Inc.
发明人： Nina E. Weisser , Gordon Yiu Kon Ng , Grant Raymond Wickman , Surjit Bhimarao Dixit , Eric Escobar-Cabrera , Mario Sanches
IPC分类号： C07K16/32 , A61K39/395 , A61K47/68 , A61K45/06 , C07K16/30 , G01N33/574 , A61K39/00
摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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公开(公告)号：US20210189001A1
公开(公告)日：2021-06-24
申请号：US17033441
申请日：2020-09-25
申请人： Zymeworks Inc.
IPC分类号： C07K16/32 , A61K47/68 , A61K39/395 , C07K16/28
摘要： Described herein methods of using antigen-binding constructs to treat HER2+ tumors in a subject such as breast, lung, or head and neck tumors. In some aspects, the tumor volume in the subject after receiving at least seven doses of the antigen binding construct is less than the tumor volume of a control subject receiving an equivalent amount of trastuzumab. In some aspects, the survival of the subject receiving the antigen binding construct is increased as compared to a control subject receiving an equivalent amount of a non-specific control antibody or as compared to a control subject not receiving treatment.
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公开(公告)号：US20170355779A1
公开(公告)日：2017-12-14
申请号：US15526888
申请日：2015-11-26
申请人： Zymeworks Inc.
IPC分类号： C07K16/32 , A61K39/395 , A61K47/68 , C07K16/28
CPC分类号： C07K16/32 , A61K39/395 , A61K47/6803 , A61K47/6855 , A61K47/6869 , A61K47/6879 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/522 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： Described herein methods of using antigen-binding constructs to treat HER2+ tumors in a subject such as breast, lung, or head and neck tumors. In some aspects, the tumor volume in the subject after receiving at least seven doses of the antigen binding construct is less than the tumor volume of a control subject receiving an equivalent amount of trastuzumab. In some aspects, the survival of the subject receiving the antigen binding construct is increased as compared to a control subject receiving an equivalent amount of a non-specific control antibody or as compared to a control subject not receiving treatment.
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公开(公告)号：US20210403598A1
公开(公告)日：2021-12-30
申请号：US17184508
申请日：2021-02-24
申请人： Zymeworks Inc.
发明人： Nina E. Weisser , Gordon Yiu Kon NG , Grant Raymond Wickman , Surjit Bhimarao Dixit , Eric Escobar-Cabrera , Mario Sanches
IPC分类号： C07K16/32 , A61K47/68 , A61K39/395 , A61K45/06 , C07K16/30 , G01N33/574
摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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公开(公告)号：US20180282429A1
公开(公告)日：2018-10-04
申请号：US16011048
申请日：2018-06-18
申请人： Zymeworks Inc.
发明人： Nina E. Weisser , Gordon Yiu Kon Ng , Grant Raymond Wickman , Surjit Bhimarao Dixit , Eric Escobar-Cabrera , Mario Sanches
IPC分类号： C07K16/32 , A61K47/68 , A61K39/395 , A61K45/06 , C07K16/30 , G01N33/574 , A61K39/00
摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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公开(公告)号：US20230118302A1
公开(公告)日：2023-04-20
申请号：US17728491
申请日：2022-04-25
申请人： Zymeworks Inc.
发明人： Nina E. Weisser , Gordon Yiu Kon Ng , Grant Raymond Wickman , Surjit Bhimarao Dixit , Eric Escobar-Cabrera , Mario Sanches
IPC分类号： C07K16/32 , A61K47/68 , A61K39/395 , A61K45/06 , C07K16/30 , G01N33/574
摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
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公开(公告)号：US20210317212A1
公开(公告)日：2021-10-14
申请号：US17207526
申请日：2021-03-19
申请人： ZYMEWORKS INC.
摘要： Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer constructs are based on a heterodimeric Fc scaffold or on a segmented albumin scaffold. Also disclosed herein are multi-specific heteromultimer constructs that bind to HER2 and HER3.
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