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1.发明申请USE OF AN IL-31 MONOCLONAL ANTIBODY FOR ANTAGONIZING SIGNAL TRANSDUCTION IN SPINAL CORD CELLS 审中-公开IL-31单克隆抗体用于拮抗信号转导在脊髓细胞中的应用公开(公告)号：US20160222103A1
公开(公告)日：2016-08-04
申请号：US15099639
申请日：2016-04-15
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine Bilsborough
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
摘要翻译： 使用拮抗剂IL-31用于通过抑制，预防，减少，最小化，限制或最小化神经元组织中的刺激来治疗炎症和疼痛。 这样的拮抗剂包括抗体及其片段，衍生物或变体。 症状如疼痛，刺痛，致敏，与神经病相关的痒症得到改善。
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2.发明授权公开(公告)号：US08637015B2
公开(公告)日：2014-01-28
申请号：US13747899
申请日：2013-01-23
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine Bilsborough
IPC分类号： A61K39/395 , C07K16/24 , C07K14/54
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
摘要翻译： 使用拮抗剂IL-31用于通过抑制，预防，减少，最小化，限制或最小化神经元组织中的刺激来治疗炎症和疼痛。 这样的拮抗剂包括抗体及其片段，衍生物或变体。 症状如疼痛，刺痛，致敏，与神经病相关的痒症得到改善。
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3.发明申请公开(公告)号：US20180066050A1
公开(公告)日：2018-03-08
申请号：US15800980
申请日：2017-11-01
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine M. Bilsborough
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
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公开(公告)号：US08968732B2
公开(公告)日：2015-03-03
申请号：US14134278
申请日：2013-12-19
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine Bilsborough
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
摘要翻译： 使用拮抗剂IL-31用于通过抑制，预防，减少，最小化，限制或最小化神经元组织中的刺激来治疗炎症和疼痛。 这样的拮抗剂包括抗体及其片段，衍生物或变体。 症状如疼痛，刺痛，致敏，与神经病相关的痒症得到改善。
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5.发明申请公开(公告)号：US20190112369A1
公开(公告)日：2019-04-18
申请号：US16227307
申请日：2018-12-20
申请人： ZymoGenetics, Inc
发明人： Yue Yao , Janine M. Bilsborough
IPC分类号： C07K16/24 , A61K38/17 , C07K16/28 , A61K39/395
摘要： Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
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公开(公告)号：US09828431B2
公开(公告)日：2017-11-28
申请号：US15461090
申请日：2017-03-16
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine Bilsborough
IPC分类号： A61K39/395 , C07K16/28 , A61K38/17 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
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7.发明申请METHOD TREATING NEURONAL TISSUE INFLAMMATION USING AN IL-31RA MONOCLONAL ANTIBODY 审中-公开使用IL-31RA单克隆抗体治疗神经组织炎症的方法公开(公告)号：US20160222123A1
公开(公告)日：2016-08-04
申请号：US15099647
申请日：2016-04-15
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine Bilsborough
IPC分类号： C07K16/28
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
摘要翻译： IL-31Ra和OSMRb的拮抗剂的使用用于通过抑制，预防，减少，最小化，限制或最小化神经元组织中的刺激来治疗炎症和疼痛。 这样的拮抗剂包括可溶性受体，抗体及其片段，衍生物或变体。 症状如疼痛，刺痛，致敏，与神经病相关的痒症得到改善。
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8.发明授权Methods of treating neuronal inflammation using an IL-31 monoclonal antibody 有权使用IL-31单克隆抗体治疗神经元炎症的方法公开(公告)号：US09334321B2
公开(公告)日：2016-05-10
申请号：US14603406
申请日：2015-01-23
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine Bilsborough
IPC分类号： A61K39/395 , A61K38/16 , A61K38/00 , C07K16/28 , C07K14/435 , C07K16/24 , A61K38/17 , A61K39/00
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
摘要翻译： 使用拮抗剂IL-31用于通过抑制，预防，减少，最小化，限制或最小化神经元组织中的刺激来治疗炎症和疼痛。 这样的拮抗剂包括抗体及其片段，衍生物或变体。 症状如疼痛，刺痛，致敏，与神经病相关的痒症得到改善。
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9.发明授权公开(公告)号：US08974783B2
公开(公告)日：2015-03-10
申请号：US14175117
申请日：2014-02-07
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine Bilsborough
IPC分类号： A61K39/395 , C07K16/28 , A61K38/17 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
摘要翻译： IL-31Ra和OSMRb的拮抗剂的使用用于通过抑制，预防，减少，最小化，限制或最小化神经元组织中的刺激来治疗炎症和疼痛。 这样的拮抗剂包括可溶性受体，抗体及其片段，衍生物或变体。 症状如疼痛，刺痛，致敏，与神经病相关的痒症得到改善。
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10.发明申请公开(公告)号：US20180044426A1
公开(公告)日：2018-02-15
申请号：US15799445
申请日：2017-10-31
申请人： ZymoGenetics, Inc.
发明人： Yue Yao , Janine M. Bilsborough
CPC分类号： C07K16/244 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/76
摘要： Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
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