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公开(公告)号：US20180215833A1
公开(公告)日：2018-08-02
申请号：US15854312
申请日：2017-12-26
申请人： argenx BVBA
发明人： Anna HULTBERG , Michael SAUNDERS , Johannes DE HAARD , Els FESTJENS , Natalie DE JONGE , Paolo MICHIELI , Cristina Basilico , Torsten DREIER
摘要： The present invention relates to antibodies that specifically bind to the human c-Met receptor protein and that act as strict antagonists of hepatocyte growth factor (HGF)-mediated activation of the c-Met receptor and also inhibit HGF-independent activation of the human c-Met protein.
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公开(公告)号：US20210332140A1
公开(公告)日：2021-10-28
申请号：US17194950
申请日：2021-03-08
申请人： argenx BVBA , VIB VZW , Universiteit Gent
发明人： Jean-Michel PERCIER , Christophe BLANCHETOT , Michael SAUNDERS , Hans DE HAARD , Sebastian VAN DER WONING , Emma PERSSON , Bart LAMBRECHT , Savvas SAVVIDES , Hamida HAMMAD , Kenneth VERSTRAETE
摘要： The present invention relates to antagonists, particularly antibodies and antigen binding fragments thereof, that bind to the protein galectin-10, particularly human galectin-10. The galectin-10 antagonists disrupt the crystallization of galectin-10 and are therefore useful in methods of preventing and treating diseases and conditions wherein the pathology is linked to the formation/presence of Charcot-Leyden crystals (CLCs).
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公开(公告)号：US20200216528A1
公开(公告)日：2020-07-09
申请号：US16661783
申请日：2019-10-23
申请人： argenx BVBA
发明人： Christophe Frederic Jerome BLANCHETOT , Birgitte URSØ , Tine SKAK-NIELSEN , Malene BERTELSEN , Sebastian VAN DER WONING , Michael SAUNDERS , Johannes Joseph Wilhelmus DE HAARD
摘要： The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.
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公开(公告)号：US20230088269A1
公开(公告)日：2023-03-23
申请号：US17819161
申请日：2022-08-11
申请人： argenx BVBA
发明人： Christophe Frederic Jerome BLANCHETOT , Birgitte URSØ , Tine SKAK-NIELSEN , Malene BERTELSEN , Sebastian VAN DER WONING , Michael SAUNDERS , Johannes Joseph Wilhelmus DE HAARD
摘要： The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.
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公开(公告)号：US20190127459A1
公开(公告)日：2019-05-02
申请号：US16242760
申请日：2019-01-08
申请人： argenx BVBA
发明人： Christophe Frederic Jerome BLANCHETOT , Birgitte URSØ , Tine SKAK-NIELSEN , Malene BERTELSEN , Sebastian VAN DER WONING , Michael SAUNDERS , Johannes Joseph Wilhelmus DE HAARD
摘要： The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.
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公开(公告)号：US20200157207A1
公开(公告)日：2020-05-21
申请号：US16661757
申请日：2019-10-23
申请人： argenx BVBA
发明人： Christophe Frederic Jerome BLANCHETOT , Birgitte URSØ , Tine SKAK-NIELSEN , Malene BERTELSEN , Sebastian VAN DER WONING , Michael SAUNDERS , Johannes Joseph Wilhelmus DE HAARD
摘要： The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.
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