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    PHARMACEUTICAL COMPOSITIONS
    1.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号：US20090196890A1

    公开(公告)日：2009-08-06

    申请号：US12337052

    申请日：2008-12-17

    申请人： Alfred Liang ,  Franklin Johnson ,  Xiaohong Qi

    发明人： Alfred Liang ,  Franklin Johnson ,  Xiaohong Qi

    IPC分类号： A61K9/00 ,  A61K31/34

    CPC分类号： A61K31/485 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/4808 ,  A61K9/485 ,  A61K9/4866 ,  A61K9/501 ,  A61K9/5078 ,  A61K45/06 ,  A61K2300/00

    摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.

    摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。

    Sustained-Release Opioid Formulations and Methods of Use
    2.
    发明申请
    Sustained-Release Opioid Formulations and Methods of Use 审中-公开
    持续释放阿片样物质的配方和使用方法

    公开(公告)号：US20130072514A1

    公开(公告)日：2013-03-21

    申请号：US13413334

    申请日：2012-03-06

    申请人： Garth Boehm ,  Alfred Liang

    发明人： Garth Boehm ,  Alfred Liang

    IPC分类号： A61K31/485 ,  A61P25/04

    CPC分类号： A61K9/5084 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5078 ,  A61K31/485

    摘要： The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) , is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.

    摘要翻译： 本发明在新的持续释放口服剂型中组合了具有不同释放特征的两种不同亚基。 特别地，口服剂型包括包含阿片类镇痛药和缓释材料的亚基，其中当通过US Pharmacopeia XXVI（2003）的标准USP药物释放试验测量时，亚单位的体外溶出速率< 在约6小时内小于约10％，在约24小时内小于约60％; 在约8小时内小于约10％，在约24小时内至少约60％; 在约12小时内小于约10％，在约24小时内至少约60％; 所述剂型提供约24小时的治疗效果的持续时间。

    Sequestering subunit and related compositions and methods
    3.
    发明授权
    Sequestering subunit and related compositions and methods 有权
    螯合亚单位及相关组合物和方法

    公开(公告)号：US07815934B2

    公开(公告)日：2010-10-19

    申请号：US10667676

    申请日：2003-09-22

    申请人： Garth Boehm

    发明人： Garth Boehm

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/48

    CPC分类号： A61K9/5078 ,  A61K9/2077 ,  A61K9/209

    摘要： A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit and a therapeutic agent in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.

    摘要翻译： 包含厌恶剂和封闭剂的螯合亚单位，其中所述封闭剂基本上防止所述厌食剂从所述胃肠道中的螯合亚单位释放大于24小时的时间; 包含螯合亚基和可释放形式的治疗剂的组合物，其中任选地，螯合亚单位的机械脆性与治疗剂的可释放形式的机械脆性相同; 包含螯合亚单位和治疗剂的胶囊或片剂; 以及防治治疗剂的滥用的方法。

    Sequestering subunit and related compositions and methods
    6.
    发明授权
    Sequestering subunit and related compositions and methods 有权
    螯合亚单位及相关组合物和方法

    公开(公告)号：US08685444B2

    公开(公告)日：2014-04-01

    申请号：US12766488

    申请日：2010-04-23

    申请人： Garth Boehm

    发明人： Garth Boehm

    IPC分类号： A61K9/48 ,  A61K9/20 ,  A61K9/42

    CPC分类号： A61K9/5078 ,  A61K9/2077 ,  A61K9/209

    摘要： A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.

    摘要翻译： 包含厌恶剂和封闭剂的螯合亚单位，其中所述封闭剂基本上防止所述厌食剂从所述胃肠道中的螯合亚单位释放大于24小时的时间; 包含可释放形式的螯合亚单位的组合物，其中任选地，螯合亚单位的机械脆性与治疗剂的可释放形式的机械脆性相同; 包含螯合亚单位和治疗剂的胶囊或片剂; 以及防治治疗剂的滥用的方法。

    Sequestering subunit and related compositions and methods
    7.
    发明授权
    Sequestering subunit and related compositions and methods 有权

    公开(公告)号：US08685443B2

    公开(公告)日：2014-04-01

    申请号：US12766472

    申请日：2010-04-23

    申请人： Garth Boehm

    发明人： Garth Boehm

    IPC分类号： A61K9/48 ,  A61K9/20 ,  A61K9/26 ,  A61K9/54 ,  A61K9/58

    CPC分类号： A61K9/5078 ,  A61K9/2077 ,  A61K9/209

    摘要： A sequestering subunit comprising an aversive agent and a blocking agent, wherein the blocking agent substantially prevents release of the aversive agent from the sequestering subunit in the gastrointestinal tract for a time period that is greater than 24 hours; a composition comprising a sequestering subunit in releasable form, wherein, optionally, the mechanical fragility of the sequestering subunit is the same as the mechanical fragility of the therapeutic agent in releasable form; a capsule or tablet comprising a sequestering subunit and a therapeutic agent; and a method of preventing abuse of a therapeutic agent.

    Pharmaceutical Composition
    8.
    发明申请
    Pharmaceutical Composition 审中-公开
    药物组成

    公开(公告)号：US20140037721A1

    公开(公告)日：2014-02-06

    申请号：US14050861

    申请日：2013-10-10

    申请人： Alpharma pharmaceuticals LLC

    发明人： Alfred Liang ,  Frank Matthews ,  Garth Boehm ,  Lijuan Tang ,  Frank Johnson ,  Joseph Stauffer

    IPC分类号： A61K31/485 ,  A61K9/48

    CPC分类号： A61K31/485 ,  A61K9/0002 ,  A61K9/4808 ,  A61K9/5026 ,  A61K9/5078

    摘要： Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.

    摘要翻译： 本文提供的药物组合物包含拮抗剂，激动剂，密封涂层和螯合聚合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 层将拮抗剂与激动剂彼此物理分离。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。