公开(公告)号：US10251889B2

公开(公告)日：2019-04-09

申请号：US15724601

申请日：2017-10-04

Applicant: Array BioPharma, Inc.

Inventor： Shelley Allen ,  Steven W. Andrews ,  Kevin Ronald Condroski ,  Julia Haas ,  Lily Huang ,  Yutong Jiang ,  Timothy Kercher ,  Jeongbeob Seo

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07D453/02 ,  C07D471/22 ,  C07D498/22 ,  A61K31/5377

Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

公开(公告)号：US20080194558A1

公开(公告)日：2008-08-14

申请号：US12081725

申请日：2008-04-21

Applicant: Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

Inventor： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC: A61K31/5377 ,  C07D239/94 ,  C07D413/02 ,  C07D401/12 ,  A61K31/517 ,  A61K31/497 ,  A61P35/00

CPC classification number: C07D498/10 ,  C04B35/632 ,  C07D239/94 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

Abstract: This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract translation: 本发明涉及式I的喹唑啉类似物：其中A基团与双环的5,6,7或8位上的至少一个碳键合，并且该环被多达三个独立的R“ > 3个组。 本发明还包括使用这些化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。