公开(公告)号：US11371057B2

公开(公告)日：2022-06-28

申请号：US16704487

申请日：2019-12-05

申请人： Bayer Intellectual Property GmbH

发明人： Ruediger Hain ,  Gerhard Johann ,  Guenter Donn

IPC分类号： C12N15/82 ,  A01N25/00 ,  A01N43/50 ,  A01N43/54 ,  A01N43/653 ,  A01N43/66 ,  A01N43/88 ,  A01N43/90

摘要： Present invention relates to the use of the ALS inhibitor herbicides for controlling unwanted vegetation in ALS inhibitor herbicide tolerant Beta vulgaris plants, more especially, present invention relates to the use of ALS inhibitor herbicides for control of unwanted vegetation in Beta vulgaris, preferably in sugar beet growing areas in which the Beta vulgaris, preferably sugar beet comprise a mutation in codon 1705-1707 of an endogenous ALS gene encoding an ALS protein containing an amino acid that is different from tryptophan at position 569, preferably the tryptophan is substituted by leucine.

公开(公告)号：US20220153745A1

公开(公告)日：2022-05-19

申请号：US17516542

申请日：2021-11-01

申请人： Bayer Intellectual Property GmbH ,  Bayer Pharma Aktiengesellschaft

发明人： Dirk BROHM ,  Melanie HEROULT ,  Marie-Pierre COLLIN ,  Walter HÜBSCH ,  Mario LOBELL ,  Klemens LUSTIG ,  Sylvia GRÜNEWALD ,  Ulf BÖMER ,  Verena VÖHRINGER

IPC分类号： C07D487/04 ,  C07D409/14 ,  C07D409/04 ,  A61P35/00 ,  A61K31/53 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/541

摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.

公开(公告)号：US11202447B2

公开(公告)日：2021-12-21

申请号：US13965855

申请日：2013-08-13

申请人： Bayer Intellectual Property Gmbh

发明人： Markus Dollinger ,  Hans-Joachim Santel ,  Ernst Rudolf Gesing ,  Erwin Hacker

IPC分类号： A01N43/653 ,  A01N47/38 ,  A01N43/56

摘要： The invention relates to herbicidal compositions comprising an effective amount of an active ingredient combination composed of (a) at least one substituted thien-3-ylsulfonylamino(thio)carbonyl-triazolin(thi) one of the formula (I) in which R1, R2 and R3 are as defined in the description, —or salts of the compounds of the formula (I)— and (b) one or more compounds from a second group of herbicides which comprises selected 4-HPPD inhibitors, and, if desired, additionally (c) a crop plant tolerance promoter compound. The invention further relates to the use of the compositions for controlling unwanted plant growth and to a process for producing the compositions.

公开(公告)号：US11147274B2

公开(公告)日：2021-10-19

申请号：US16369725

申请日：2019-03-29

申请人： BAYER INTELLECTUAL PROPERTY GMBH

发明人： Ulrike Wachendorff-Neumann ,  Sebastian Hoffmann ,  Pierre Wasnaire

IPC分类号： A01N43/80 ,  A01N47/12 ,  A01N59/26 ,  A01N25/00 ,  A01N37/34 ,  A01N43/38 ,  A01N43/40 ,  A01N43/54 ,  A01N43/56 ,  A01N43/90 ,  A01N47/08 ,  A01N47/28 ,  A01N57/12

摘要： The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

公开(公告)号：US10463666B2

公开(公告)日：2019-11-05

申请号：US14965173

申请日：2015-12-10

申请人： MERCK & CIE ,  Bayer Intellectual Property GmbH

发明人： Kai Strothmann ,  Gavin Welch Wasserfall-Smith ,  Klaus Pietrzik ,  Kristina King ,  Rudolf Moser

IPC分类号： A61K31/519 ,  A61K31/4415 ,  A61K31/525 ,  A61K31/56 ,  A61K31/565 ,  A61K31/57 ,  A61K31/585 ,  A61K45/06 ,  A61K31/567

摘要： The present invention relates to a pharmaceutical composition which comprises progestogens, preferably drospirenone, estrogens, preferably ethinylestradiol and 5-methyl-(6S)-tetrahydrofolate, can be employed as oral contraceptive and moreover prevents disorders caused by folate deficiency in the consumers, in particular cardiovascular disorders and, after conception of the embryo, congenital malformations caused by folate deficiency such as, for example, neural tube defects, ventricular valve defects, urogenital defects, and cleft lip, jaw and palate, without masking the symptoms of vitamin B12 deficiency, and at the same time even in the case of homozygous or heterozygous polymorphism of methylenetetrahydrofolate reductase facilitates unimpaired utilizability of the folate component 5-methyl-(6S)-tetrahydrofolate by the body and thus its biological activity for preventing the abovementioned congenital malformations caused by folate deficiency. In addition, a prolonged protective effect is maintained after discontinuation of the contraceptive.

公开(公告)号：US10414762B2

公开(公告)日：2019-09-17

申请号：US15884159

申请日：2018-01-30

申请人： Bayer Intellectual Property GmbH

发明人： Joachim Luithle ,  Frank-Gerhard Böβ ,  Christina Erb ,  Katrin Schnizler ,  Timo Flessner ,  Marja van Kampen ,  Christoph Methfessel

IPC分类号： A61K31/439 ,  C07D453/02 ,  C07D453/04

摘要： The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.

公开(公告)号：US10091990B2

公开(公告)日：2018-10-09

申请号：US15593355

申请日：2017-05-12

申请人： Bayer Intellectual Property GmbH

发明人： David A. Long

IPC分类号： A01N25/22 ,  A01N25/30 ,  A01N57/20 ,  A01N25/02 ,  A01N57/12

摘要： A liquid herbicidal composition is provided, comprising: a. 20 to 35 percent by weight, based on the total weight of the composition, of a water-soluble herbicidal ingredient; b. a C12-C16 alkyl ether sulfate; c. an organic solvent; and d. an alkyl polyglucoside. The composition is stable; i.e., it occurs in a substantially continuous, single phase at temperatures as low as −20° C. It also has a viscosity of no more than 2000 cps at temperatures as low as 0° C.

公开(公告)号：USRE47047E1

公开(公告)日：2018-09-18

申请号：US15080187

申请日：2016-03-24

申请人： ASTRAZENECA AB ,  BAYER INTELLECTUAL PROPERTY GMBH

发明人： Markus Berger ,  Hartmut Rehwinkel ,  Thomas Zollner ,  Ekkehard May ,  Jorma Hassfeld ,  Heike Schaecke

IPC分类号： A61K31/04 ,  C07D215/38 ,  C07C45/00 ,  C07D405/12 ,  C07C45/58 ,  C07C49/84 ,  C07C45/71 ,  C07C49/82 ,  C07D303/32

摘要： The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.

公开(公告)号：US20180258181A1

公开(公告)日：2018-09-13

申请号：US15911748

申请日：2018-03-05

申请人： Bayer Intellectual Property GmbH

发明人： Antje KAHNERT ,  David LIGHT ,  Doug SCHNEIDER ,  Renate PARRY ,  Noboru SATOZAWA ,  Tara HEITNER ,  Stefan STEIDL ,  Ulrike SCHUBERT

IPC分类号： C07K16/30

CPC分类号： C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

公开(公告)号：US20180194730A1

公开(公告)日：2018-07-12

申请号：US15884103

申请日：2018-01-30

申请人： BAYER INTELLECTUAL PROPERTY GMBH

发明人： Alfons GRUNENBERG ,  Juergen STIEHL ,  Katharina TENBIEG ,  Birgit KEIL

IPC分类号： C07D213/78 ,  C07D213/81 ,  A61K45/06 ,  C07D213/62 ,  A61K31/44

CPC分类号： C07D213/78 ,  A61K31/44 ,  A61K45/06 ,  C07D213/62 ,  C07D213/81

摘要： The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.