公开(公告)号：US11298025B2

公开(公告)日：2022-04-12

申请号：US15729285

申请日：2017-10-10

申请人： DermaSensor, Inc.

发明人： John Noto ,  Robert Kerr ,  Maurice Ferre

IPC分类号： A61B5/00

摘要： A non-invasive, optical method and device for the detection of melanoma in skin lesions. The detection of the presence of melanoma is accomplished optically by looking for specific changes (signatures) in the spectrum of optical light elastically scattered off melanoma molecules. Elastic scattering spectroscopy (ESS) converts subcellular morphological changes into scattering spectrum signatures. A melanoma discrimination analysis is performed by illuminating the lesion with a handheld device that also collects a portion of the scattered light, converts it into digital signals, analyzes the requisite spectral signatures, and provides a logical output showing the user the presence (or absence) of melanoma in the subject lesion.

公开(公告)号：US20240341602A1

公开(公告)日：2024-10-17

申请号：US18752486

申请日：2024-06-24

申请人： DermaSensor, Inc.

发明人： Steven Ryan FREIDEN ,  Warren Stewart MACCHI ,  Cody Vance SIMMONS

IPC分类号： A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/444 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2560/0238

摘要： Methods and devices are disclosed for calibrating intensity of a light source for evaluating a skin lesion using Elastic-Scattering Spectroscopy (ESS). The ESS system illuminates a skin lesion with a pulse from the light source adjusted to a high output setting, receives a signal comprising an elastic scattering spectrum from illuminating the skin lesion at the high output setting, determines whether the received signal has an intensity that is greater than a saturation threshold associated with at least one optical detection sensor, and if so, stores the elastic scattering spectrum. If less than the saturation threshold, the ESS system illuminates the skin lesion with a pulse from the light source adjusted to a low output setting, receives a signal comprising an elastic scattering spectrum from illuminating the skin lesion sample at the low output setting, and stores the elastic scattering spectrum at the low output setting.

公开(公告)号：US09788730B2

公开(公告)日：2017-10-17

申请号：US13788595

申请日：2013-03-07

申请人： DermaSensor, Inc.

发明人： John Noto ,  Robert Kerr ,  Maurice Ferre

IPC分类号： A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/0022 ,  A61B5/0077 ,  A61B5/444 ,  A61B5/6843 ,  A61B5/6898 ,  A61B5/7465

摘要： A non-invasive, optical method and device for the detection of melanoma in skin lesions. The detection of the presence of melanoma is accomplished optically by looking for specific changes (signatures) in the spectrum of optical light elastically scattered off melanoma molecules. Elastic scattering spectroscopy (ESS) converts subcellular morphological changes into scattering spectrum signatures. A melanoma discrimination analysis is performed by illuminating the lesion with a handheld device that also collects a portion of the scattered light, converts it into digital signals, analyzes the requisite spectral signatures, and provides a logical output showing the user the presence (or absence) of melanoma in the subject lesion.

公开(公告)号：US12053263B2

公开(公告)日：2024-08-06

申请号：US17327317

申请日：2021-05-21

申请人： DermaSensor, Inc.

发明人： Steven Ryan Freiden ,  Warren Stewart Macchi ,  Cody Vance Simmons

IPC分类号： A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/444 ,  A61B5/6843 ,  A61B2560/0233 ,  A61B2560/0238

摘要： Methods and devices are disclosed for calibrating intensity of a light source in a system of evaluating a skin lesion using Elastic-Scattering Spectroscopy (ESS). The ESS system may illuminate a sample of the skin lesion with a pulse from the light source adjusted to a high output setting, receive a signal comprising an elastic scattering spectrum from illuminating the skin lesion sample at the high output setting, determine whether the received signal has an intensity that is greater than a saturation threshold associated with at least one optical detection sensor, and if so, store the elastic scattering spectrum from illuminating the skin lesion sample at the high output setting. If not greater than the saturation threshold, the ESS system may illuminate the skin lesion sample with a pulse from the light source adjusted to a low output setting, receive a signal comprising an elastic scattering spectrum from illuminating the skin lesion sample at the low output setting, and store the elastic scattering spectrum from illuminating the skin lesion sample at the low output setting.

公开(公告)号：US20220378295A1

公开(公告)日：2022-12-01

申请号：US17327317

申请日：2021-05-21

申请人： DermaSensor, Inc.

发明人： Steven Ryan FREIDEN ,  Warren Stewart MACCHI ,  Cody Vance SIMMONS

IPC分类号： A61B5/00

摘要： Methods and devices are disclosed for calibrating intensity of a light source in a system of evaluating a skin lesion using Elastic-Scattering Spectroscopy (ESS). The ESS system may illuminate a sample of the skin lesion with a pulse from the light source adjusted to a high output setting, receive a signal comprising an elastic scattering spectrum from illuminating the skin lesion sample at the high output setting, determine whether the received signal has an intensity that is greater than a saturation threshold associated with at least one optical detection sensor, and if so, store the elastic scattering spectrum from illuminating the skin lesion sample at the high output setting. If not greater than the saturation threshold, the ESS system may illuminate the skin lesion sample with a pulse from the light source adjusted to a low output setting, receive a signal comprising an elastic scattering spectrum from illuminating the skin lesion sample at the low output setting, and store the elastic scattering spectrum from illuminating the skin lesion sample at the low output setting.

公开(公告)号：US20130253335A1

公开(公告)日：2013-09-26

申请号：US13788595

申请日：2013-03-07

申请人： DERMASENSOR, INC.

发明人： John Noto ,  Robert Kerr ,  Maurice Ferre

IPC分类号： A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/0022 ,  A61B5/0077 ,  A61B5/444 ,  A61B5/6843 ,  A61B5/6898 ,  A61B5/7465

摘要： A non-invasive, optical method and device for the detection of melanoma in skin lesions. The detection of the presence of melanoma is accomplished optically by looking for specific changes (signatures) in the spectrum of optical light elastically scattered off melanoma molecules. Elastic scattering spectroscopy (ESS) converts subcellular morphological changes into scattering spectrum signatures. A melanoma discrimination analysis is performed by illuminating the lesion with a handheld device that also collects a portion of the scattered light, converts it into digital signals, analyzes the requisite spectral signatures, and provides a logical output showing the user the presence (or absence) of melanoma in the subject lesion.

摘要翻译： 用于检测皮肤损伤中黑素瘤的非侵入性光学方法和装置。 通过寻找弹性散射出黑素瘤分子的光学光谱中的特定变化（特征）来光学地实现对黑素瘤的存在的检测。 弹性散射光谱（ESS）将亚细胞形态学变化转化为散射光谱特征。 通过用收集一部分散射光的手持设备照射病变来进行黑素瘤鉴别分析，将其转换为数字信号，分析必要的光谱特征，并提供一个逻辑输出，显示用户的存在（或不存在） 的黑色素瘤。