公开(公告)号：US07962225B2

公开(公告)日：2011-06-14

申请号：US12195197

申请日：2008-08-20

申请人： William N. Aldrich ,  David Miller

发明人： William N. Aldrich ,  David Miller

IPC分类号： A61N1/05

CPC分类号： A61B5/4233 ,  A61B5/04001 ,  A61B8/12 ,  A61B8/445 ,  A61B17/2202 ,  A61B18/1477 ,  A61B2018/00482 ,  A61N7/02 ,  A61N7/022

摘要： Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

公开(公告)号：US07430449B2

公开(公告)日：2008-09-30

申请号：US11067185

申请日：2005-02-24

申请人： William N. Aldrich ,  David Miller

发明人： William N. Aldrich ,  David Miller

IPC分类号： A61N1/36

CPC分类号： A61B5/4233 ,  A61B5/04001 ,  A61B8/12 ,  A61B8/445 ,  A61B17/2202 ,  A61B18/1477 ,  A61B2018/00482 ,  A61N7/02 ,  A61N7/022

摘要： Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

摘要翻译： 用于在胃食管区域中破坏胃迷走神经的方法和装置，并测试迷走神经的功能和破坏。 在一个示例性实施例中，治疗装置以高能量级（例如高强度聚焦超声）将超声波应用于迷走神经以将其破坏，然后以较低的能量级别向迷走神经的另一部分超声波，优选地进一步从 胃，以刺激迷走神经。 测试迷走神经功能或破坏的其他方法包括使用PCP-GABA，胰多肽，胃内压力变化，胃粘蛋白pH，胃中的染料剂等测试。

公开(公告)号：US07991474B2

公开(公告)日：2011-08-02

申请号：US12054694

申请日：2008-03-25

申请人： William N. Aldrich ,  David Miller

发明人： William N. Aldrich ,  David Miller

IPC分类号： A61N1/36

CPC分类号： A61B5/4233 ,  A61B5/04001 ,  A61B8/12 ,  A61B8/445 ,  A61B17/2202 ,  A61B18/1477 ,  A61B2018/00482 ,  A61N7/02 ,  A61N7/022

摘要： Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

摘要翻译： 用于在胃食管区域中破坏胃迷走神经的方法和装置，并测试迷走神经的功能和破坏。 在一个示例性实施例中，治疗装置以高能量级（例如高强度聚焦超声）将超声波应用于迷走神经以将其破坏，然后以较低的能量级别向迷走神经的另一部分超声波，优选地进一步从 胃，以刺激迷走神经。 测试迷走神经功能或破坏的其他方法包括使用PCP-GABA，胰多肽，胃内压力变化，胃粘蛋白pH，胃中的染料剂等测试。

公开(公告)号：US20050240231A1

公开(公告)日：2005-10-27

申请号：US11067185

申请日：2005-02-24

申请人： William Aldrich ,  David Miller

发明人： William Aldrich ,  David Miller

IPC分类号： A61B18/14 ,  A61N7/02 ,  A61N1/18

CPC分类号： A61B5/4233 ,  A61B5/04001 ,  A61B8/12 ,  A61B8/445 ,  A61B17/2202 ,  A61B18/1477 ,  A61B2018/00482 ,  A61N7/02 ,  A61N7/022

摘要： Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.

摘要翻译： 用于在胃食管区域中破坏胃迷走神经的方法和装置，并测试迷走神经的功能和破坏。 在一个示例性实施例中，治疗装置以高能量级（例如高强度聚焦超声）将超声波应用于迷走神经以将其破坏，然后以较低的能量级别向迷走神经的另一部分超声波，优选地进一步从 胃，以刺激迷走神经。 测试迷走神经功能或破坏的其他方法包括使用PCP-GABA，胰多肽，胃内压力变化，胃粘蛋白pH，胃中的染料剂等测试。

公开(公告)号：US20050203501A1

公开(公告)日：2005-09-15

申请号：US11067063

申请日：2005-02-24

申请人： William Aldrich ,  David Miller

发明人： William Aldrich ,  David Miller

IPC分类号： A61B18/14 ,  A61N7/02 ,  A61B18/04

CPC分类号： A61B8/4461 ,  A61B8/12 ,  A61B8/445 ,  A61B18/02 ,  A61B18/04 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00026 ,  A61B2017/22051 ,  A61B2018/00011 ,  A61B2018/00482 ,  A61B2018/1425 ,  A61N7/02 ,  A61N7/022

摘要： Method and apparatus for treating obesity by an energy delivery device, such as a high focus ultrasound transducer, mounted for movement along two or three axes relative to the esophagus to deliver transesophageal energy to interrupt the function of vagal nerves. Preferably, movement along a longitudinal axis of the esophagus changes the site to which the energy is directed and movement transversely along a radius of the esophagus focuses the energy on a vagal nerve. The third degree of freedom relative to the esophagus is to rotate the transducer about the longitudinal axis of the esophagus.

摘要翻译： 用于通过能量递送装置（例如高焦距超声换能器）来治疗肥胖的方法和装置，其安装成相对于食道沿着两个或三个轴线移动，以输送经食管能量来中断迷走神经的功能。 优选地，沿着食道的纵向轴线的运动改变了能量所指向的位置，并且沿着食管的半径横向移动将能量聚焦在迷走神经上。 相对于食道的第三自由度是围绕食管的纵轴旋转传感器。

公开(公告)号：US07783358B2

公开(公告)日：2010-08-24

申请号：US11067063

申请日：2005-02-24

申请人： William N. Aldrich ,  David Miller

发明人： William N. Aldrich ,  David Miller

IPC分类号： A61N1/08

CPC分类号： A61B8/4461 ,  A61B8/12 ,  A61B8/445 ,  A61B18/02 ,  A61B18/04 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00026 ,  A61B2017/22051 ,  A61B2018/00011 ,  A61B2018/00482 ,  A61B2018/1425 ,  A61N7/02 ,  A61N7/022

摘要： Method and apparatus for treating obesity by an energy delivery device, such as a high focus ultrasound transducer, mounted for movement along two or three axes relative to the esophagus to deliver transesophageal energy to interrupt the function of vagal nerves. Preferably, movement along a longitudinal axis of the esophagus changes the site to which the energy is directed and movement transversely along a radius of the esophagus focuses the energy on a vagal nerve. The third degree of freedom relative to the esophagus is to rotate the transducer about the longitudinal axis of the esophagus.

摘要翻译： 用于通过能量递送装置（例如高焦距超声换能器）来治疗肥胖的方法和装置，其安装成相对于食道沿着两个或三个轴线移动，以输送经食管能量来中断迷走神经的功能。 优选地，沿着食道的纵向轴线的运动改变了能量所指向的位置，并且沿着食管的半径横向移动将能量聚焦在迷走神经上。 相对于食道的第三自由度是围绕食管的纵轴旋转传感器。

公开(公告)号：US07684865B2

公开(公告)日：2010-03-23

申请号：US10389236

申请日：2003-03-14

申请人： William Aldrich ,  David Miller

发明人： William Aldrich ,  David Miller

IPC分类号： A61N1/08

CPC分类号： A61B18/1477 ,  A61B18/1492 ,  A61B2018/00482 ,  A61N7/02

摘要： Method and apparatus for treating obesity by use of transesophageal delivery of energy to interrupt the function of vagal nerves. The energy, which may be highly focused ultrasound energy or other types of energy is delivered through the wall of the esophagus by a device placed in the esophagus. The energy delivered is sufficient to ablate a vagal nerve on the outer wall of the esophagus.

摘要翻译： 通过使用经食管递送能量来中断迷走神经的功能来治疗肥胖症的方法和装置。 能够高度聚焦超声能量或其他类型能量的能量通过放置在食道中的装置通过食管壁传送。 所传送的能量足以消融食道外壁上的迷走神经。