公开(公告)号：US20240374605A1

公开(公告)日：2024-11-14

申请号：US18292582

申请日：2022-07-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Ammar Adam ,  Kana Ichikawa ,  Martin F. Hentemann ,  Lan Xu

IPC: A61K31/5377 ,  A61K31/4184 ,  A61K31/497 ,  A61K31/517 ,  A61K31/519 ,  A61K35/17 ,  A61K45/06 ,  A61P35/04

Abstract: The present disclosure features useful methods to treat cancer, e.g., in a subject in need thereof. In some embodiments, the methods described include administering an agent that reduces the level and/or activity of BRM/BRG1 in combination with an immunotherapy. In some embodiments, the immunotherapy is administered concurrently with the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject. In some embodiments, the immunotherapy is administered prior to the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject. In some embodiments, the immunotherapy is administered subsequent to the agent that reduces the level and/or activity of BRM and/or BRG1 in the subject.

公开(公告)号：US20240101550A1

公开(公告)日：2024-03-28

申请号：US18373518

申请日：2023-09-27

Applicant: FOGHORN THERAPEUTICS INC.

Inventor： Rishi G. VASWANI ,  David S. HUANG

IPC: C07D417/14 ,  A61P35/00 ,  A61P35/02

CPC classification number: C07D417/14 ,  A61P35/00 ,  A61P35/02

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20240024488A1

公开(公告)日：2024-01-25

申请号：US18253541

申请日：2021-11-22

Applicant: Foghorn Therapeutics Inc.

Inventor： Matthew NETHERTON ,  Francois BRUCELLE ,  Jing DENG ,  Johannes H. VOIGT

IPC: A61K47/54 ,  A61K47/55

CPC classification number: A61K47/545 ,  A61K47/55

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20230416248A1

公开(公告)日：2023-12-28

申请号：US18252228

申请日：2021-11-10

Applicant: Foghorn Therapeutics Inc.

Inventor： Kevin J. WILSON ,  Solymar NEGRETTI ,  Shawn E.R. SCHILLER ,  Rishi G. VASWANI ,  David S. HUANG ,  Johannes H. VOIGT

IPC: C07D471/04 ,  C07D519/00 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D519/00 ,  A61P35/00

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US11851445B2

公开(公告)日：2023-12-26

申请号：US17162608

申请日：2021-01-29

Applicant: Foghorn Therapeutics Inc.

Inventor： Sabine K. Ruppel ,  Zhaoxia Yang ,  Jason T. Lowe ,  Johannes H. Voigt

IPC: C07D519/00 ,  A61P35/00 ,  A61P35/02 ,  A61K47/54 ,  A61K47/55 ,  C07D471/10 ,  A61K31/4545 ,  A61K31/12

CPC classification number: C07D519/00 ,  A61P35/00

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20230150974A1

公开(公告)日：2023-05-18

申请号：US17907463

申请日：2021-04-06

Applicant: Foghorn Therapeutics Inc.

Inventor： Matthew NETHERTON ,  Francois BRUCELLE

IPC: C07D401/14 ,  C07D417/14 ,  C07D487/10 ,  C07D471/10

CPC classification number: C07D401/14 ,  C07D417/14 ,  C07D487/10 ,  C07D471/10

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20230129003A1

公开(公告)日：2023-04-27

申请号：US17963576

申请日：2022-10-11

Applicant: Foghorn Therapeutics Inc.

Inventor： Rishi G. VASWANI ,  David S. HUANG

IPC: C07D417/14 ,  A61P35/02 ,  A61P35/00

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20230064136A1

公开(公告)日：2023-03-02

申请号：US17858875

申请日：2022-07-06

Applicant: Foghorn Therapeutics Inc.

Inventor： Chong-Hui GU ,  Joshua D. WAETZIG

IPC: C07D519/00

Abstract: The present disclosure features citrate salts and pharmaceutical compositions useful for the treatment of BAF complex-related disorders. Also disclosed are methods for preparing compounds.

公开(公告)号：US20220289711A1

公开(公告)日：2022-09-15

申请号：US17631791

申请日：2020-07-31

Applicant: Foghorn Therapeutics Inc.

Inventor： Sabine K. RUPPEL ,  Zhaoxia YANG ,  Jason T. LOWE

IPC: C07D401/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

公开(公告)号：US20220079940A1

公开(公告)日：2022-03-17

申请号：US17325937

申请日：2021-05-20

Applicant: Foghorn Therapeutics Inc.

Inventor： Richard C. CENTORE ,  Lan XU ,  David LAHR ,  Ammar ADAM

IPC: A61K31/501 ,  A61K45/06 ,  A61P35/04 ,  A61P35/02

Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as acute myeloid leukemia.