公开(公告)号：US20030086948A1

公开(公告)日：2003-05-08

申请号：US09935277

申请日：2001-08-22

申请人： GATTEFOSSE S.A.

发明人： Hassan Benameur ,  Vincent Jannin ,  Delphine Roulot

IPC分类号： A61K031/366 ,  A61K031/225 ,  A61K009/20

CPC分类号： A61K9/4858 ,  A61K9/1075 ,  A61K31/366

摘要： A pharmaceutical composition for oral use is disclosed. It includes, as active principle, a drug liable to undergo a strong first intestinal passage effect and a carrier which is self-micro-emulsifying on contact with an aqueous phase. The carrier includes: a therapeutically effective amount of the active principle; a lipophilic phase, which is a mixture of glycerol mono-, di- and triesters and of PEG mono- and diesters with at least one fatty acid chosen from the group comprising C8-C18 fatty acids; a surfactant phase which is a mixture of glycerol mono-, di- and triesters and of PEG mono- and diesters with caprylic acid (C8) and capric acid (C10); a co-surfactant phase which is an ester of a polyvalent alcohol with at least one fatty acid chosen from the group comprising caprylic esters of propylene glycol, lauric esters of propylene glycol and oleic esters of polyglycerol. A method of decreasing the effect of intestinal metabolism on a drug using the composition is also disclosed.

摘要翻译： 公开了口服用药物组合物。 作为活性成分，作为活性成分，含有易于经受强烈的第一次肠通过作用的药物和与水相接触时自乳化的载体。 载体包括：治疗有效量的活性成分; 亲脂相，其是甘油单酯，二酯和三酯的混合物，以及PEG单酯和二酯与至少一种选自C8-C18脂肪酸的脂肪酸的混合物; 甘油单酯，二酯和三酯和PEG单酯和二酯与辛酸（C8）和癸酸（C10）的混合物的表面活性剂相; 辅助表面活性剂相，其是多元醇与至少一种脂肪酸的酯，所述脂肪酸选自丙二醇的辛酸酯，丙二醇的月桂酸酯和聚甘油的油酸酯。 还公开了使用该组合物降低肠代谢对药物的作用的方法。

公开(公告)号：US6054136A

公开(公告)日：2000-04-25

申请号：US838893

申请日：1997-04-11

申请人： Nabil Farah ,  Joel Denis

发明人： Nabil Farah ,  Joel Denis

IPC分类号： A61K8/06 ,  A61K8/39 ,  A61K9/107 ,  A61Q19/00 ,  A61K9/00

CPC分类号： A61K8/375 ,  A61K8/068 ,  A61K8/39 ,  A61K9/1075 ,  A61Q19/00 ,  A61K2800/92

摘要： Composition for pharmaceutical or cosmetic use, capable of forming a microemulsion, comprising at least:an active principle,a lipophilic phase consisting of a mixture of fatty acid esters and glycerides,a surfactant (SA),a cosurfactant (CoSA),a hydrophilic phase,characterized:in that the lipophilic phase consists of a mixture of C.sub.8 to C.sub.18 polyglycolized glycerides having a hydrophilic-lipophilic balance (HLB) of less than 16, this lipophilic phase representing from 30 to 75% of the total weight of the composition;in that the surfactant (SA) is chosen from the group comprising saturated C.sub.8 -C.sub.10 olyglycolized glycerides and oleic esters of polyglycerol, this surfactant having an HLB of less than 16;in that the cosurfactant (CoSA) is chosen from the group comprising lauric esters of propylene glycol, oleic esters of polyglycerol and ethyl diglycol;in that the SA/CoSA ratio is between 0.5 and 6;and in that the hydrophilic phase of the final microemulsion is supplied after ingestion by the physiological fluid of the digestive milieu.

摘要翻译： 能够形成微乳液的组合物，其至少包含：活性成分，由脂肪酸酯和甘油酯的混合物组成的亲油相，表面活性剂（SA），辅助表面活性剂（CoSA），亲水相 其特征在于：亲脂相由亲水 - 亲油平衡（HLB）小于16的C8-C18聚乙二醇化甘油酯的混合物组成，该亲油相占组合物总重量的30-75％ 表面活性剂（SA）选自饱和的C8-C10乙二醇化的甘油酯和聚甘油的油酸酯的组，该表面活性剂的HLB小于16; 辅助表面活性剂（CoSA）选自丙二醇的月桂酸酯，聚甘油的油酸酯和乙基二甘醇; 因为SA / CoSA比率在0.5和6之间; 并且由消化环境的生理液体吸收后提供最终微乳液的亲水相。

公开(公告)号：US5998392A

公开(公告)日：1999-12-07

申请号：US630520

申请日：1996-04-10

申请人： Veronique Simard ,  David Garlen ,  Kenneth Klein

发明人： Veronique Simard ,  David Garlen ,  Kenneth Klein

IPC分类号： A61K8/38 ,  A61K8/39 ,  A61K9/00 ,  A61K31/327 ,  A61K31/60 ,  A61K47/10 ,  A61Q19/00 ,  A61K31/605

CPC分类号： A61Q19/00 ,  A61K31/327 ,  A61K47/10 ,  A61K8/38 ,  A61K8/39 ,  A61K9/0014

摘要： Improved compositions of benzoyl peroxide are prepared by at least partially dissolving benzoyl peroxide in diethylene glycol monoethyl ether to prepare a premixture which forms a flocculent composition of benzoyl peroxide when admixed with water or an aqueous medium. The improved benzoyl peroxide compositions have a small particle size compared with those prepared by conventional grinding techniques and the time and potential hazards associated with grinding are avoided. The small particle size of the benzoyl peroxide flocculents result in increased surface area of active ingredient on the skin for a given concentration of benzoyl peroxide. The flocculent compositions are used to prepare compositions for the topical treatment of acne or other dermatological disorders.

摘要翻译： 通过至少部分地将过氧化苯甲酰溶解在二甘醇单乙醚中来制备过氧化苯甲酰的组合物，以制备当与水或水性介质混合时形成过氧化苯甲酰的絮状组合物的预混合物。 与通过常规研磨技术制备的那些相比，改进的过氧化苯甲酰组合物具有小的粒度，并且避免了与研磨相关的时间和潜在危害。 过氧化苯甲酰絮凝剂的小粒径导致给定浓度的过氧化苯甲酰对皮肤上活性成分的表面积增加。 絮状组合物用于制备用于局部治疗痤疮或其它皮肤病的组合物。

公开(公告)号：US5108775A

公开(公告)日：1992-04-28

申请号：US663406

申请日：1991-03-01

申请人： Robert Bousser

发明人： Robert Bousser

IPC分类号： A23L2/04 ,  A23L27/10

CPC分类号： A23L2/04 ,  A23L27/10

摘要： A process for obtaining juices, oils and cakes in stable form by the pressing of fresh plant products is disclosed in which a depressor system in the amount of two to two-and-a-half times the quantity of water contained in the product to be pressed is added to a quantity of crushed product. The depressor system is a mixture of dextrose, saccharose and salt in a proportion by weight of dextrose to saccharose of three times and sugars to salt between seven and seven-and-a-half times. The whole mixture is subjected to exhaustive crushing action to obtain a puree and the puree is then pressed to obtain the juices, oils and cakes in stable form.

摘要翻译： 公开了通过压榨新鲜植物产品获得稳定形式的果汁，油和蛋糕的方法，其中抑制剂体系的量为产品中所含的水量的2至2.5倍 加入一定量的粉碎产品。 降压剂体系是葡萄糖，蔗糖和盐的重量比，葡萄糖与蔗糖的重量比为三倍，糖分为七至七五倍之间。 对整个混合物进行彻底的破碎作用以获得泥浆，然后压榨泥浆以获得稳定形式的果汁，油和蛋糕。