公开(公告)号：US12238197B2

公开(公告)日：2025-02-25

申请号：US17057950

申请日：2019-05-24

Applicant: Howard University

Inventor： Mamadou Ibra Wade

IPC: H04L9/00 ,  H04L9/30 ,  H04L9/14

Abstract: Encryption of an image is achieved through application of a homomorphic encryption function to produce cipher images for each image. Encryption is performed individually on sub-values of a pixel's intensity value, wherein the pixel's intensity value can be described as a sum of the smaller numerical sub-values. The encrypted values for each sub-value form encrypted images that can be transferred or stored on insecure media. Separate encryption approaches can be applied to individual sets of the numerical sub-values to improve security.

公开(公告)号：US20240216328A1

公开(公告)日：2024-07-04

申请号：US18490008

申请日：2023-10-19

Applicant: HOWARD UNIVERSITY

Inventor： Simeon Kolawole ADESINA

IPC: A61K31/366 ,  A61K9/51 ,  A61K31/337 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20

CPC classification number: A61K31/366 ,  A61K9/5146 ,  A61K9/5184 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20 ,  A61K38/00

Abstract: Disclosed are bruceolides for the treatment of cancer, and oilier diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.

公开(公告)号：US11826344B2

公开(公告)日：2023-11-28

申请号：US15775986

申请日：2016-11-18

Applicant: HOWARD UNIVERSITY

Inventor： Simeon Kolawole Adesina

IPC: A61K31/366 ,  A61K31/337 ,  C07D493/20 ,  A61K47/64 ,  A61P35/00 ,  A61K38/00 ,  A61K9/51

CPC classification number: A61K31/366 ,  A61K9/5146 ,  A61K9/5184 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20 ,  A61K38/00 ,  A61K31/337 ,  A61K2300/00 ,  A61K31/366 ,  A61K2300/00

Abstract: Disclosed are bruceolides for the treatment of cancer, and other diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.

公开(公告)号：US11780833B2

公开(公告)日：2023-10-10

申请号：US16045254

申请日：2018-07-25

Applicant: HOWARD UNIVERSITY

Inventor： Oladapo Bakare ,  Samuel Ray Denmeade ,  Emmanuel S. Akinboye

IPC: C07K7/06 ,  C07D455/08 ,  C07D401/06

CPC classification number: C07D455/08 ,  C07D401/06 ,  C07K7/06

Abstract: Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2′-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.

公开(公告)号：US20230312669A1

公开(公告)日：2023-10-05

申请号：US18173264

申请日：2023-02-23

Applicant: Howard University

Inventor： Shaolei Teng ,  Qiyi Tang

IPC: C07K14/705 ,  A61P31/14

CPC classification number: C07K14/705 ,  A61P31/14

Abstract: The present disclosure provides novel computational methods for identifying potential therapeutic peptides as antivirals, and methods of using viral receptor-derived peptides as antivirals. Further, the present disclosure provides methods of using angiotensin converting enzyme 2 (ACE2)-derived peptides as therapeutic treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused coronavirus disease 2019 (COVID-19).

公开(公告)号：US20230183703A1

公开(公告)日：2023-06-15

申请号：US17925474

申请日：2021-05-14

Applicant: Hemayet ULLAH ,  Saadyah Eliezer AVERICK ,  HOWARD UNIVERSITY

Inventor： Hemayet ULLAH

IPC: C12N15/113 ,  G01N33/569

CPC classification number: C12N15/1131 ,  G01N33/56983 ,  G01N2333/165 ,  C12N2310/11

Abstract: The present disclosure provides compositions and methods for treating and detecting coronavirus infection, and in particular embodiments, provides compositions and methods for treating and detecting SARS-CoV-2 infection. The present disclosure also relates to the production of compositions for treating and detecting coronavirus infection, and in particular embodiments, to the production of compositions for treating and detecting SARS-CoV-2 infection.

公开(公告)号：US11236053B2

公开(公告)日：2022-02-01

申请号：US16634567

申请日：2018-07-26

Applicant: Emory University ,  Mercer University ,  Howard University ,  Union University

Inventor： Osman Güner ,  Bernard Lassegue ,  Kathy Griendling ,  Qian Xu ,  David Brown ,  J. Phillip Bowen ,  Amol Kulkarni ,  E. Blake Watkins

IPC: C07D239/26 ,  C07D213/50 ,  C07D307/54 ,  C07D215/14 ,  C07D213/65

Abstract: This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.

公开(公告)号：US20210161553A1

公开(公告)日：2021-06-03

申请号：US17046449

申请日：2019-04-12

Applicant: HOWARD UNIVERSITY

Inventor： Roger C. LIN ,  Olmide A. OLULADE ,  Shannon A. SULLIVAN ,  Hamza HAIDER ,  Alexander W. SONG

IPC: A61B17/34

Abstract: In some embodiments, apparatuses and methods are provided herein useful to guide and support a medical device, such as a needle, relative to the skin of a patient. In some embodiments, the apparatus is attached to the skin of a patient through suction or adhesive materials, and allows for accurate placement of the medical instrument.

公开(公告)号：US20200163884A1

公开(公告)日：2020-05-28

申请号：US16698297

申请日：2019-11-27

Applicant: HOWARD UNIVERSITY

Inventor： Emmanuel Oyekanmi Akala

IPC: A61K9/14 ,  A61P35/00 ,  A61K31/395 ,  A61K31/337 ,  A61K47/10 ,  A61K47/18 ,  A61K47/34

Abstract: Provided is a method for preparing a drug loaded nanoparticle comprising: dissolving a macromonomer, a stabilizer and a crosslinker in a solvent to create a mixture; adding an initiator system to the mixture; dissolving a drug or combination of drugs in an organic phase containing the mixture; and recovering the drug loaded nanoparticle, a composition comprising the drug loaded nanoparticle prepared by the above method, and a method for treating cancer comprising administering the above composition to a subject in need thereof.

公开(公告)号：US10592668B2

公开(公告)日：2020-03-17

申请号：US15531139

申请日：2015-11-23

Applicant: HOWARD UNIVERSITY

Inventor： Charles J. Kim

IPC: G06F21/55 ,  G06F21/56 ,  G05B9/02 ,  G06F11/16 ,  G06F11/14

Abstract: A redundant and diverse secondary control system mirrors a primary control system but has some fundamental structural difference as compared to the primary control system to prevent a spread of a security breach from the primary control system to the secondary control system. The secondary control system may operate on different hardware built on different software written with different programming language as compared to the primary control system while performing the same function as that of the primary system. By hardware coding the algorithm to produce actuation signals, software based viruses and worms cannot interfere with the secondary control system's operation. A monitor device receives actuation signals from both the primary and secondary controls signals to determine whether an error occurred and to provide correct actuation signals to the controlled system.