公开(公告)号：US09675556B2

公开(公告)日：2017-06-13

申请号：US14575517

申请日：2014-12-18

Applicant: Howard University

Inventor： Emmanuel Oyekanmi Akala ,  Simeon Kolawole Adesina

IPC: B01J13/06 ,  B01J13/16 ,  A61K9/16 ,  A61K31/337 ,  A61K31/704 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  A61K9/51 ,  C08G63/85

CPC classification number: C08G63/78 ,  A61K9/1635 ,  A61K9/5153 ,  A61K31/337 ,  A61K31/7034 ,  A61K31/704 ,  B01J13/06 ,  B01J13/16 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C08F299/024 ,  C08G63/06 ,  C08G63/82 ,  C08G63/85 ,  C08G63/912 ,  Y10S977/773 ,  Y10T428/2982

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.

公开(公告)号：US11986557B2

公开(公告)日：2024-05-21

申请号：US16698297

申请日：2019-11-27

Applicant: HOWARD UNIVERSITY

Inventor： Emmanuel Oyekanmi Akala

IPC: A61K9/14 ,  A61K31/337 ,  A61K31/395 ,  A61K47/10 ,  A61K47/18 ,  A61K47/34 ,  A61P35/00 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: A61K9/146 ,  A61K31/337 ,  A61K31/395 ,  A61K47/10 ,  A61K47/18 ,  A61K47/34 ,  A61P35/00 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: Provided is a method for preparing a drug loaded nanoparticle comprising: dissolving a macromonomer, a stabilizer and a crosslinker in a solvent to create a mixture; adding an initiator system to the mixture; dissolving a drug or combination of drugs in an organic phase containing the mixture; and recovering the drug loaded nanoparticle, a composition comprising the drug loaded nanoparticle prepared by the above method, and a method for treating cancer comprising administering the above composition to a subject in need thereof.

公开(公告)号：US20200163884A1

公开(公告)日：2020-05-28

申请号：US16698297

申请日：2019-11-27

Applicant: HOWARD UNIVERSITY

Inventor： Emmanuel Oyekanmi Akala

IPC: A61K9/14 ,  A61P35/00 ,  A61K31/395 ,  A61K31/337 ,  A61K47/10 ,  A61K47/18 ,  A61K47/34

Abstract: Provided is a method for preparing a drug loaded nanoparticle comprising: dissolving a macromonomer, a stabilizer and a crosslinker in a solvent to create a mixture; adding an initiator system to the mixture; dissolving a drug or combination of drugs in an organic phase containing the mixture; and recovering the drug loaded nanoparticle, a composition comprising the drug loaded nanoparticle prepared by the above method, and a method for treating cancer comprising administering the above composition to a subject in need thereof.

公开(公告)号：US20140274929A1

公开(公告)日：2014-09-18

申请号：US14292314

申请日：2014-05-30

Applicant: HOWARD UNIVERSITY

Inventor： Emmanuel Oyekanmi Akala ,  Oluyomi Modupe Okunola

IPC: A61K9/16 ,  C08F220/68 ,  A61K31/704 ,  A61K31/337 ,  A61K31/135

CPC classification number: A61K9/1641 ,  A61K9/5146 ,  A61K31/135 ,  A61K31/337 ,  A61K31/704 ,  C08F8/00 ,  C08F8/30 ,  C08F220/68 ,  C08F290/062 ,  Y10T428/2982 ,  C08F120/14 ,  C08F220/18 ,  C08F222/00

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

Abstract translation: 本发明涉及交联聚合物颗粒或非交联聚合物颗粒，其中交联聚合物颗粒包含由至少一种可水解单体或交联剂交联的聚（亚烷基二醇 - 接枝 - 丙烯酸酯）的共聚物。 本发明还涉及包含交联聚合物颗粒的聚合物颗粒，其是起始材料的产物，其包含（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂（交联剂可以 在非交联颗粒的情况下不存在）。 本发明还涉及包含交联共聚物的聚合物颗粒，其中交联共聚物包括如说明书中所定义的由式（I），（II）和（III）表示的结构。 本发明的其它实施方案还包括制备聚合物颗粒的方法。

公开(公告)号：US09358211B2

公开(公告)日：2016-06-07

申请号：US14292314

申请日：2014-05-30

Applicant: Howard University

Inventor： Emmanuel Oyekanmi Akala ,  Oluyomi Modupe Okunola

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/337 ,  A61K31/704 ,  C08F220/68 ,  C08F8/00 ,  C08F8/30 ,  A61K9/51 ,  C08F290/06

CPC classification number: A61K9/1641 ,  A61K9/5146 ,  A61K31/135 ,  A61K31/337 ,  A61K31/704 ,  C08F8/00 ,  C08F8/30 ,  C08F220/68 ,  C08F290/062 ,  Y10T428/2982 ,  C08F120/14 ,  C08F220/18 ,  C08F222/00

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

Abstract translation: 本发明涉及交联聚合物颗粒或非交联聚合物颗粒，其中交联聚合物颗粒包含由至少一种可水解单体或交联剂交联的聚（亚烷基二醇 - 接枝 - 丙烯酸酯）的共聚物。 本发明还涉及包含交联聚合物颗粒的聚合物颗粒，其是起始材料的产物，其包含（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂（交联剂可以 在非交联颗粒的情况下不存在）。 本发明还涉及包含交联共聚物的聚合物颗粒，其中交联共聚物包括如说明书中所定义的由式（I），（II）和（III）表示的结构。 本发明的其它实施方案还包括制备聚合物颗粒的方法。

公开(公告)号：US20150209287A1

公开(公告)日：2015-07-30

申请号：US14575517

申请日：2014-12-18

Applicant: Howard University

Inventor： Emmanuel Oyekanmi Akala ,  Simeon Kolawole Adesina

IPC: A61K9/16 ,  A61K31/337 ,  C08G63/85

CPC classification number: C08G63/78 ,  A61K9/1635 ,  A61K9/5153 ,  A61K31/337 ,  A61K31/7034 ,  A61K31/704 ,  B01J13/06 ,  B01J13/16 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C08F299/024 ,  C08G63/06 ,  C08G63/82 ,  C08G63/85 ,  C08G63/912 ,  Y10S977/773 ,  Y10T428/2982

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.

Abstract translation: 本发明涉及交联或非交联聚合物颗粒，其中交联聚合物颗粒包含由至少一种可水解单体交联的聚（烷二醇 - 接枝 - 乳酸）共聚物。 本发明的另一个实施方案是包含交联聚合物颗粒的聚合物颗粒，其是起始材料的产物，其包含（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂。 本发明的另一个实施方案是包含交联共聚物的聚合物颗粒，其包含由式（I），（II）和（III）表示的结构，其中式（I），（II）和（III） 规范。 本发明的其它实施方案包括制备甲基丙烯酸酯封端的大分子单体的方法，制备交联剂的方法，以及通过分散聚合制备负载纳米球的治疗剂的方法。