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1.发明申请公开(公告)号：US20190338294A1
公开(公告)日：2019-11-07
申请号：US16467890
申请日：2017-12-07
发明人： Jef D. Boeke , Shigehito Ikushima
摘要： The invention features compositions and methods for identifying orthogonal transcriptional switches derived from Tet repressor homologs for Saccharomyces cerevishiae regulated by 2,4-diacetylphloroglucinol (DAPG) and other ligands.
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公开(公告)号：US11634491B2
公开(公告)日：2023-04-25
申请号：US17739278
申请日：2022-05-09
发明人： Luis Diaz , Bert Vogelstein , Kenneth W. Kinzler , Nickolas Papadopoulos , Dung Le , Drew M. Pardoll , Suzanne L. Topalian
摘要： Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.
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公开(公告)号：US20230120340A1
公开(公告)日：2023-04-20
申请号：US18068598
申请日：2022-12-20
发明人： Jennifer H. Elisseeff , Liam Chung , Xiaokun Wang
摘要： Provided herein, inter alia, are methods of treating an ocular injury, disease or disorder with use of one or more extracellular matrix materials.
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公开(公告)号：US20230100402A1
公开(公告)日：2023-03-30
申请号：US17946416
申请日：2022-09-16
IPC分类号： A61K31/7068 , A61P35/00 , A61K31/203 , A61K31/4188 , A61K31/55
摘要： The disclosure generally relates to compositions and methods for the treatment of cancer. In some aspects, disclosed herein are methods for the induction of synthetic lethality with epigenetic therapy (ISLET) using a combination of at least one epigenetic compound and at least one chemotherapeutic agent. Also disclosed herein are screening methods for identifying compounds that induce killing of cancer cells when combined with at least one epigenetic compound. Further disclosed herein are methods of potentiating a therapeutic effect of a chemotherapeutic agent against a cancer, comprising administering to a subject having the cancer an epigenetic compound in an amount effective to potentiate the therapeutic effect of the chemotherapeutic agent against the cancer.
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公开(公告)号：US20230094514A1
公开(公告)日：2023-03-30
申请号：US17489851
申请日：2021-09-30
摘要： A continuous flow process (CFP) for the production of an acid chloride includes the following steps: (i) providing or forming a first reactant comprising a chlorine-donating compound; (ii) providing or forming a second reactant comprising a carboxylic acid; (iii) providing a first continuous flow of the first reactant into a reactor at a first flow rate; (iv) providing a second continuous flow of the second reactant into the reactor at a second flow rate; and (v) mixing the first reactant and the second reactant in a portion of the reactor and reacting the first reactant and the second reactant to provide a reaction product comprising an acid chloride.
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6.发明申请公开(公告)号：US20230083448A1
公开(公告)日：2023-03-16
申请号：US17798064
申请日：2021-02-05
发明人： Hai-Quan Mao , Gregory P. Howard
IPC分类号： A61K39/00 , C01F7/746 , A61K9/51 , A61K39/39 , A61P35/00 , A61K39/07 , A61K39/05 , A61K39/08 , A61K39/29 , A61K39/015 , A61K39/13 , A61K39/09 , A61K39/02 , A61K39/12
摘要： An aluminum nanoparticle adjuvant carrier system with stabilizing surface coatings that can efficiently deliver protein or nucleic acid antigen payloads to naive, resident APCs is disclosed.
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公开(公告)号：US20230075584A1
公开(公告)日：2023-03-09
申请号：US17737229
申请日：2022-05-05
发明人： BARBARA S. SLUSHER , RANA RAIS
IPC分类号： A61K9/00 , A61K51/04 , A61K31/194 , A61K31/198 , A61K31/662 , A61P25/28 , A61K49/00 , A61K31/27
摘要： The presently disclosed subject matter provides methods for treating and diagnosing neurological diseases or disorders using intranasal administration of glutamate carboxypeptidase II (GCP-II) inhibitors in a subject. Methods for imaging GCP-II in a subject, including imaging of the brain and/or peripheral nervous system, also are provided.
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公开(公告)号：US11596679B2
公开(公告)日：2023-03-07
申请号：US16608308
申请日：2018-04-27
申请人： VANDERBILT UNIVERSITY , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE JOHNS HOPKINS UNIVERSITY
发明人： James E. Crowe, Jr. , Andrew Flyak , Justin Bailey , Stuart Ray , George Shaw
摘要： The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.
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9.发明申请公开(公告)号：US20230065974A1
公开(公告)日：2023-03-02
申请号：US17793144
申请日：2021-01-14
发明人： Ehud J. Schmidt , Yue Chen , Akila Viswanathan , Henry R. Halperin , Junichi Tokuda , Anthony Gunderman
摘要： Provided herein are methods of analyzing tissue using a magnetic resonance imaging (MRI) compatible tissue analysis device that includes radio¬frequency (RF) tracking and imaging elements. Related kits, systems, and computer program products are also provided.
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公开(公告)号：US20230060178A1
公开(公告)日：2023-03-02
申请号：US17781455
申请日：2020-12-02
发明人： Rebekka Klausen , Yuyang Ji
IPC分类号： C08F130/06 , C08F230/06 , C08F212/32 , C08F212/10
摘要： Described are methods using aromatic vinyl borane monomers for the preparation of highly functionalized copolymers bearing vinyl alcohol, lactone, and ester side chains.
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