公开(公告)号：US3928352A

公开(公告)日：1975-12-23

申请号：US46770874

申请日：1974-05-07

Applicant: LILLY CO ELI

Inventor： TAYLOR HAROLD M

IPC: A01N43/60 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18 ,  C07D241/20

CPC classification number: C07D241/12 ,  C07D241/16 ,  C07D241/18 ,  C07D241/20

Abstract: A new series of 2-pyrazinemethanols useful for the protection of plants from microbial diseases has been discovered. The new compounds are characterized by alkyl, cycloalkyl or phenyl substituents on the Alpha -carbon and by a single additional substituent on the pyrazine ring. Many of the compounds are additionally useful for the inhibition of plant growth.

Abstract translation: 已经发现了一系列用于保护植物免受微生物疾病的2-吡嗪甲醇。 新化合物的特征在于α-碳上的烷基，环烷基或苯基取代基和吡嗪环上的单个另外的取代基。 许多化合物另外可用于抑制植物生长。

公开(公告)号：US3927020A

公开(公告)日：1975-12-16

申请号：US41509973

申请日：1973-09-10

Applicant: LILLY CO ELI

Inventor： MIESEL JOHN L

IPC: C07D235/10

CPC classification number: C07D235/10

Abstract: 4-Substituted-5,7-dinitro-2-( Alpha , Alpha difluoroalkyl)benzimidazole compounds and their alkali metal and alkaline earth metal salts, useful as insecticides.

Abstract translation: 4-取代的5,7-二硝基-2-（α，α-二氟烷基）苯并咪唑化合物及其碱金属和碱土金属盐，可用作杀虫剂。

公开(公告)号：US3926978A

公开(公告)日：1975-12-16

申请号：US43920674

申请日：1974-02-06

Applicant: LILLY CO ELI

Inventor： KOPPEL GARY A

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B61/00 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/59

CPC classification number: C07D501/00 ,  Y02P20/55

Abstract: An ester of a 7-acylamido-3-fluoro-3-cephem-4-carboxylic acid is prepared by reacting a 3-sulfonate ester of an ester of a 7acylamido-3-hydroxy-3-cephem-4-carboxylic acid in an inert solvent with an inorganic fluoride in the presence of an 18crown-6 ether and at a temperature of from about -20* C. to about +25* C.

Abstract translation: 7-酰基氨基-3-氟-3-头孢烯-4-羧酸的酯通过7-酰基氨基-3-羟基-3-头孢烯-4-羧酸的酯的3-磺酸酯 在具有无机氟化物的惰性溶剂中，在18-冠醚-6存在下和约-20℃至约+ 25℃的温度下进行。

公开(公告)号：US3922268A

公开(公告)日：1975-11-25

申请号：US6269970

申请日：1970-08-10

Applicant: LILLY CO ELI

Inventor： MURPHY CHARLES F ,  WEBBER J ALAN

IPC: C07D501/04 ,  C07D501/20 ,  C07D501/24

CPC classification number: C07D501/04 ,  C07D501/24

Abstract: 3-Halomethyl- Delta 3-cephalosporin (sulfide) esters and sulfoxides thereof, prepared by reacting a phosphorus halide with a 3-hydroxymethyl- Delta 3-cephalosporin sulfoxide ester, which sulfide esters can be de-esterified to form antibiotics, and which sulfide ester and sulfoxide ester products are useful as intermediates in the production of known and new antibiotics.

Abstract translation: 通过使卤化磷与3-羟甲基-D-3β-头孢菌素亚砜酯反应制备的3-卤代甲基-D-TA-三头孢菌素（硫化物）酯和其亚砜，该硫化物酯可被脱酯化形成抗生素，并且该硫化物 酯和亚砜酯产品可用作生产已知和新型抗生素的中间体。

公开(公告)号：US3920809A

公开(公告)日：1975-11-18

申请号：US41301273

申请日：1973-11-05

Applicant: LILLY CO ELI

Inventor： THAKKAR ARVIND L

IPC: A61K9/14 ,  A61K31/35 ,  A61K31/79

CPC classification number: A61K9/146 ,  A61K31/35

Abstract: 1-Hydroxy-3-alkyl-9-keto or 9-hydroxyhexahydro dibenzo(b, d)pyrans, useful as tranquilizers or hypotensive agents are dispersed with PVP or polyethylene glycol.

公开(公告)号：US3920634A

公开(公告)日：1975-11-18

申请号：US50213174

申请日：1974-08-30

Applicant: LILLY CO ELI

Inventor： DINNER ALAN

IPC: C07J71/00 ,  C07J17/00

CPC classification number: C07J71/0005

Abstract: 2'',3''-Dihydroestra-1,3,5(10)-trieno(16 Alpha ,17 Alpha -b Beta furan-17 Beta -ols are new compounds useful in the treatment of menopausal syndrome and other conditions of estrogen deficiency.

Abstract translation: 2'，3'-二氢雌-1,3,5（10） - 三烯[16α，17α-ββ呋喃-17β-醇是可用于治疗绝经综合征和其他雌激素缺乏症的新化合物。

公开(公告)号：US3917679A

公开(公告)日：1975-11-04

申请号：US46064374

申请日：1974-04-12

Applicant: LILLY CO ELI

Inventor： MOLLOY BRYAN B ,  TUTTLE RONALD R

IPC: C07C217/84 ,  A61K31/14 ,  C07C67/00 ,  C07C209/00 ,  C07C209/12 ,  C07C209/20 ,  C07C211/63 ,  C07C211/64 ,  C07C213/00 ,  C07D295/13 ,  C07C87/46

CPC classification number: C07D295/13 ,  Y10S514/821

Abstract: Novel quaternary ammonium salts of lower dialkylaminoalkyl derivatives of N-(2-indanyl)anilines are potent antiarrhythmic agents.

Abstract translation: N-（2,3-二氢化茚基）苯胺的低级二烷基氨基烷基衍生物的新型季铵盐是有效的抗心律失常药。

公开(公告)号：US3917055A

公开(公告)日：1975-11-04

申请号：US43111674

申请日：1974-01-07

Applicant: LILLY CO ELI

Inventor： VANDENBERG WILLARD J ,  RAMSEY ROBERT E ,  BOLLMAN ROBERT L ,  KRACKENBERGER RICHARD E ,  PIECZKO GEORGE

IPC: B65G17/36 ,  A61J3/07 ,  B65B35/44 ,  B65B35/56 ,  B65G47/14 ,  B65G47/22 ,  B65G65/42 ,  B65G47/24

CPC classification number: A61J3/074 ,  B65G47/1471

Abstract: Randomly oriented medicinal capsules are processed to a uniform cap-forward orientation at high handling rates. The capsules are conveyed endwise in a series of deep conveyor cavities, each with an upper portion to loosely contain the capsule, with shoulders at the bottom of such portion defining a rectification slot of a width to pass a capsule body but retain its cap, and deep enough below the shoulders to substantially contain the body of an upstanding capsule supported at its cap edge by the shoulders. The conveyor slopes upward and is centrally slotted to straddle a thin cam rail which supports capsules lengthwise in the upper portions of the cavities. In a rectification zone, the cam rail rises to lift the capsules well away from the side shoulders, and then terminates abruptly above a suction passage which draws air downward through the conveyor cavities. As a body-forward capsule crosses the rail terminus, its rear end is supported by the rail and its forward end is unsupported in the downward air stream. This tips it forward about the rail terminus and its body passes through the slot. Its cap edge is carried into engagement with the side shoulders with sufficient momentum and at an angular orientation which causes the cap edges to wedge slightly between the side shoulders to form two side points of engagement about which further tilting tends to occur and which resists sliding of the capsule lengthwise of the cavity shoulders. The tilting carries the capsule to a forward-leaning position, and the capsule then engages an underlying secondary cam rail which rises to lift the lower end of the capsule. Such lifting, combined with continuing downward air flow, moves the capsule to a cap-forward position in the cavity. Any capsule which may slip rearward in its cavity is contained by the deep walls, and is lifted by the secondary cam without danger of being pinched or caught. Capsules originally in cap-forward position are not changed, since their forward caps will be supported by the cavity shoulders as the capsules cross the rectification zone.

Abstract translation: 以高处理率将随机取向的药用胶囊加工成均匀的前后方向。 胶囊以一系列深的输送器空腔传送，每个具有上部以松散地容纳胶囊，其中该部分底部的肩部限定宽度的整流槽以通过胶囊主体但保持其盖，并且 深度足以在肩部下方基本上容纳由肩部在其帽边缘处支撑的直立胶囊的主体。 输送机向上倾斜并且中心地开槽，以跨过一个薄的凸轮轨道，其在纵向上在空腔的上部支撑胶囊。

公开(公告)号：US3915947A

公开(公告)日：1975-10-28

申请号：US48770174

申请日：1974-07-11

Applicant: LILLY CO ELI

Inventor： SHIELDS JAMES E

IPC: A61K38/00 ,  C07K7/23 ,  C07C103/52 ,  A61K37/00

CPC classification number: C07K7/23 ,  A61K38/00 ,  Y10S514/80 ,  Y10S930/13

Abstract: A compound of the formula PyroGlu-Trp-Ser-Tyr-D-Ala-Leu-Arg-ProNHCH2CH3 as well as its pharmaceutically acceptable acid addition salts exhibit inhibiting action toward luteinizing hormone release hormone (LH-RH) and are potent contraceptives.

Abstract translation: 式PyroGlu-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHCH2CH3的化合物及其药学上可接受的酸加成盐对黄体激素释放激素（LH-RH）表现出抑制作用，并且是有效的避孕药 。

公开(公告)号：US3914401A

公开(公告)日：1975-10-21

申请号：US45288874

申请日：1974-03-20

Applicant: LILLY CO ELI

Inventor： SHARABASH MOUSTAFA M

IPC: A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  C08F8/00 ,  A61K27/00

CPC classification number: A61K9/5084 ,  A61K9/2846 ,  A61K9/4891 ,  A61K9/5078 ,  C08F8/00 ,  C08F20/02

Abstract: Partial alkylene glycol ether esters of C1-C4 alkyl acrylateunsaturated polybasic carboxylic acid anhydride copolymers and useful enteric compositions prepared therewith.

Abstract translation: C1-C4烷基丙烯酸酯 - 不饱和多元羧酸酐共聚物的部分亚烷基二醇醚酯和用其制备的有用的肠溶组合物。