公开(公告)号：US20240325609A1

公开(公告)日：2024-10-03

申请号：US18482421

申请日：2023-10-06

申请人： Trustees of Tufts College

发明人： Fiorenzo G. Omenetto ,  David L. Kaplan ,  Benedetto Marelli ,  Chunmei Li

IPC分类号： A61L27/56 ,  A61K9/50 ,  A61L27/22 ,  A61L27/46

CPC分类号： A61L27/56 ,  A61L27/227 ,  A61L27/46 ,  A61K9/5052 ,  A61L2300/62

摘要： The present application relates to amphiphilic polypeptide materials, methods for making and using the same. Provided amphiphilic polypeptide materials are water-based and manufactured using all aqueous processing. Provided materials exhibit a capacity to encapsulate and store biologically active molecules or macromolecules. Such biologically active molecules or macromolecules retain their structure and the biological activity so that these biologically active molecules or macromolecules are not materially degraded, reduced, and/or inhibited by processing steps or exposure. Provided materials possess unique mechanical and structural properties, including size, density, moldability and machinability.

公开(公告)号：US12048775B2

公开(公告)日：2024-07-30

申请号：US17395647

申请日：2021-08-06

申请人： Abyrx, Inc.

发明人： Richard L. Kronenthal ,  Aniq Darr ,  John Pacifico

IPC分类号： A61B17/88 ,  A61L24/00 ,  A61L24/02 ,  A61L24/04 ,  A61L27/16 ,  A61L27/18 ,  A61L27/42 ,  A61L27/44 ,  A61L27/46 ,  C08L33/12 ,  C08L75/04

CPC分类号： A61L24/043 ,  A61L24/0005 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/02 ,  A61L27/16 ,  A61L27/18 ,  A61L27/427 ,  A61L27/44 ,  A61L27/46 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/38 ,  C08L33/12 ,  C08L75/04 ,  A61L27/18 ,  C08L75/04 ,  A61L27/18 ,  C08L71/02 ,  A61L27/16 ,  C08L33/10

摘要： The present disclosure provides methods of stabilizing surgical screws comprising the intraoperative mixing of reactive putties to yield a homogenous putty composition (HPC) into which the screw is inserted, wherein the HPC comprises a polyurethane or polyurethane urea copolymer, one or more particulate materials, and one or more additive materials.

公开(公告)号：US20240226380A9

公开(公告)日：2024-07-11

申请号：US18275263

申请日：2022-02-02

申请人： Kuros Biosciences B.V. ,  Medskin Solutions Dr. Suwelack AG

发明人： Florence De Groot-Barrere ,  Nathan Kucko ,  Charlie Campion ,  Huipin Yuan ,  Kay Mohr ,  Wolfgang Ernst Weinmar ,  Annalena Anja Völker ,  Claudia Doberenz

IPC分类号： A61L27/46 ,  A61L27/24 ,  A61L27/56

CPC分类号： A61L27/46 ,  A61L27/24 ,  A61L27/56 ,  A61L2430/02

摘要： The invention is directed to a porous osteoinductive composite comprising osteoinductive granules embedded in a porous matrix, wherein more than 5% of the surface area of the osteoinductive granules is exposed from said matrix as determined by scanning electron microscopy (SEM) imaging. Such a composite can suitably be used in a medical treatment, for example in a medical treatment of connective tissue and/or bone loss or defect.

公开(公告)号：US20240197958A1

公开(公告)日：2024-06-20

申请号：US18286764

申请日：2021-12-26

申请人： BLOOCELL SAGLIK TEKNOLOJILERI SANAYI VE TICARET LIMITED SIRKETI

发明人： Gazi HURI ,  Oktay TOPALOGLU ,  Mustafa Cüneyt CIKMAN

IPC分类号： A61L27/34 ,  A61L27/46 ,  A61L27/52 ,  A61L27/56 ,  A61L27/58 ,  B33Y80/00 ,  C08L5/08

CPC分类号： A61L27/34 ,  A61L27/46 ,  A61L27/52 ,  A61L27/56 ,  A61L27/58 ,  B33Y80/00 ,  C08L5/08 ,  A61L2430/02 ,  A61L2430/06

摘要： A polymer scaffold structure is created as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing/supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.

公开(公告)号：US11806440B2

公开(公告)日：2023-11-07

申请号：US17131022

申请日：2020-12-22

申请人： NFS IP Holdings, LLC

发明人： Jed K. Johnson ,  Devan Ohst ,  Jason Chakroff ,  Brian Cohen ,  Anthony Romeo

IPC分类号： A61L27/18 ,  A61L27/12 ,  A61L27/10 ,  A61L27/36 ,  A61B17/04 ,  A61L27/46 ,  A61F2/08 ,  A61B17/00

CPC分类号： A61L27/18 ,  A61B17/0401 ,  A61L27/10 ,  A61L27/12 ,  A61L27/3662 ,  A61L27/46 ,  A61B2017/00526 ,  A61B2017/00884 ,  A61B2017/0406 ,  A61B2017/0414 ,  A61B2017/0464 ,  A61B2017/0495 ,  A61F2/0811 ,  A61F2002/0852 ,  A61F2002/0858 ,  A61L2300/64 ,  A61L2430/10 ,  A61L27/46 ,  C08L67/04

摘要： The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.

公开(公告)号：US20230248885A1

公开(公告)日：2023-08-10

申请号：US18134603

申请日：2023-04-14

申请人： Northwestern University

发明人： Ramille N. Shah ,  Adam E. Jakus

IPC分类号： A61L27/56 ,  A61L27/54 ,  A61L27/58 ,  C09D167/04 ,  A61L27/46 ,  C09D11/037 ,  C09D11/104 ,  C09D11/322 ,  B33Y70/10

CPC分类号： A61L27/56 ,  A61L27/54 ,  A61L27/58 ,  C09D167/04 ,  A61L27/46 ,  C09D11/037 ,  C09D11/104 ,  C09D11/322 ,  B33Y70/10 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2300/442

摘要： Ink formulations comprising bioactive particles, methods of printing the inks into three-dimensional (3D) structures, and methods of making the inks are provided. Also provided are objects, such as tissue growth scaffolds and artificial bone, made from the inks, methods of forming the objects using 3D printing techniques, and method for growing tissue on the tissue growth scaffolds. The inks comprise a plurality of bioactive ceramic particles, a biocompatible polymer binder, optionally at least one bioactive factor, and a solvent.

公开(公告)号：US11690934B2

公开(公告)日：2023-07-04

申请号：US17507355

申请日：2021-10-21

申请人： XELITE BIOMED LTD.

发明人： Chung-Wei Kao ,  Yung-He Liang

IPC分类号： A61L27/00 ,  A61L27/12 ,  A61L27/10 ,  A61L27/46 ,  A61L27/56

CPC分类号： A61L27/12 ,  A61L27/10 ,  A61L27/46 ,  A61L27/56 ,  A61L2430/02

摘要： This present invention discloses a bone implant composition which comprises about 50˜70% by weight of ceramic particles, wherein the ceramic particles composes tricalcium phosphate and bioactive glass; and about 30˜50% by weight of carrier. The carrier provides good ability of operation and shaping, so the bone implant composition can be filled into a human body by various shapes. Because of high ratio of ceramic particles, it can still construct supports even if carrier is degraded within a short time after implanted, which is beneficial for adhesion and growth of new bone cells, and also promotes healing of bone defect.

公开(公告)号：US20190247803A1

公开(公告)日：2019-08-15

申请号：US16344505

申请日：2017-10-24

申请人： Trustees of Tufts College ,  Massachusetts Institute of Technology

发明人： David L. Kaplan ,  Markus J. Buehler ,  Shengjie Ling

IPC分类号： B01D69/14 ,  B01D71/74 ,  B01D71/02 ,  B01D69/12 ,  C02F1/44 ,  B01D67/00 ,  D01B7/00

CPC分类号： B01D69/144 ,  A61L27/3604 ,  A61L27/46 ,  A61L27/56 ,  A61L2400/12 ,  B01D67/0079 ,  B01D69/12 ,  B01D71/02 ,  B01D71/74 ,  C02F1/44 ,  C02F2101/22 ,  D01B7/00

摘要： The present invention provides, inter alia, compositions including at least one pliable layer comprising a plurality of silk fibroin nanofibrils, and at least one rigid layer comprising a plurality of mineral crystals, wherein each rigid layer is associated with at least one pliable layer, as well as methods for the production and use thereof.

公开(公告)号：US20190216515A1

公开(公告)日：2019-07-18

申请号：US16314111

申请日：2017-06-30

申请人： TEKNIMED

发明人： Julien IEHL ,  Gautier HALBIN ,  Cyril SENDER ,  Nouredine SAHRAOUI

IPC分类号： A61B17/88 ,  A61L27/12

CPC分类号： A61B17/8805 ,  A61B17/8802 ,  A61B17/8836 ,  A61F2/4601 ,  A61L27/12 ,  A61L27/16 ,  A61L27/46 ,  A61L2400/06 ,  A61L2430/02 ,  C08L67/04

摘要： The invention relates to the field of bioresorbable or non-bioresorbable bone substitutes to be implanted in humans in order to reconstitute the bone supply by replacing lost bone substance. More particularly, the invention concerns a device that is simple to manufacture and use and comprises a syringe provided with a single-use dose of a polymer which is fluid at the injection temperature while being solid and durable at body temperature.

公开(公告)号：US20190194401A1

公开(公告)日：2019-06-27

申请号：US16322219

申请日：2017-08-02

申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES

发明人： Carlos Kengla

IPC分类号： C08J3/205 ,  C08J3/12 ,  C08K3/32 ,  B29C64/118 ,  B29C64/209 ,  A61L27/46

CPC分类号： C08J3/205 ,  A61L27/46 ,  A61L27/56 ,  A61L2430/02 ,  A61P19/08 ,  B29C64/118 ,  B29C64/209 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08J3/12 ,  C08J9/008 ,  C08J2367/04 ,  C08K3/32 ,  C08K2003/325 ,  C08K2201/005 ,  C09D11/10 ,  C08L67/04

摘要： Provided herein are improved compositions and methods of making and using the same, the composition comprising a polymer and a ceramic present at a ratio of from 3:1 to 1:3 of polymer:ceramic by weight, wherein the composition comprises or is a composite of the polymer and the ceramic having improved printability and/or having an improved elastic modulus and/or improved stress at failure (e.g., as compared to a blend of the polymer and the ceramic).