公开(公告)号：US20240358887A1

公开(公告)日：2024-10-31

申请号：US18768745

申请日：2024-07-10

申请人： GROUPE PPD INC.

发明人： Daniel MORRISSETTE ,  Vincent MORRISSETTE

IPC分类号： A61L27/18 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61L27/18 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/08

摘要： A porous material suitable for implant is disclosed comprising a large plurality of substantially spherical intercalated hollows in a polymer. The hollows are formed by combining the polymer with a fugitive material under heat and pressure and subsequently removing the fugitive material to reveal the hollows. Intercalation can be increased by subjecting the fugitive material to a coalescing compacting process prior to combining the fugitive material with the polymer. The porous material can be combined with a solid material such as a solid polymer to fabricate complex implantable materials with a variety of features.

公开(公告)号：US20240277900A1

公开(公告)日：2024-08-22

申请号：US18646092

申请日：2024-04-25

申请人： Satellite Biosciences, Inc.

发明人： Arnav CHHABRA ,  Amanda CHEN ,  Keval N. VYAS ,  Thomas Jay LOWERY, JR. ,  Fabiola MUNARIN ,  Glenn Michael LA MURAGLIA, II ,  Timothy Alfred NORMAN, JR. ,  Christopher Garrison WILSON ,  Joseph E. MARTURANO ,  Morgan JAMIEL ,  Alison HAYWARD ,  Howard TAKIFF

IPC分类号： A61L27/38 ,  A61F2/02 ,  A61L27/22 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54

CPC分类号： A61L27/3839 ,  A61F2/022 ,  A61L27/225 ,  A61L27/3813 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/28

摘要： The present disclosure provides engineered tissue constructs having hepatocytes and stromal cells and methods of making and using the same (e.g., for treating acute liver failure, a urea cycle disorder, or hyperbilirubinemia (e.g., in a subject having Crigler-Najjar syndrome) in a human subject in need thereof). The engineered tissue constructs may provide a microenvironment that promotes the persistence of hepatocyte survival for at least three months.

公开(公告)号：US12048775B2

公开(公告)日：2024-07-30

申请号：US17395647

申请日：2021-08-06

申请人： Abyrx, Inc.

发明人： Richard L. Kronenthal ,  Aniq Darr ,  John Pacifico

IPC分类号： A61B17/88 ,  A61L24/00 ,  A61L24/02 ,  A61L24/04 ,  A61L27/16 ,  A61L27/18 ,  A61L27/42 ,  A61L27/44 ,  A61L27/46 ,  C08L33/12 ,  C08L75/04

CPC分类号： A61L24/043 ,  A61L24/0005 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/02 ,  A61L27/16 ,  A61L27/18 ,  A61L27/427 ,  A61L27/44 ,  A61L27/46 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/38 ,  C08L33/12 ,  C08L75/04 ,  A61L27/18 ,  C08L75/04 ,  A61L27/18 ,  C08L71/02 ,  A61L27/16 ,  C08L33/10

摘要： The present disclosure provides methods of stabilizing surgical screws comprising the intraoperative mixing of reactive putties to yield a homogenous putty composition (HPC) into which the screw is inserted, wherein the HPC comprises a polyurethane or polyurethane urea copolymer, one or more particulate materials, and one or more additive materials.

公开(公告)号：US12035953B1

公开(公告)日：2024-07-16

申请号：US18504480

申请日：2023-11-08

申请人： Spinal Simplicity, LLC

发明人： Todd Moseley ,  Luke Luallin ,  Adam Rogers ,  Christian Aragonez ,  Jeff Slover ,  Tony Hartlage

IPC分类号： A61B17/86 ,  A61B17/70 ,  A61F2/30 ,  A61F2/44 ,  A61L27/44

CPC分类号： A61B17/864 ,  A61B17/7055 ,  A61F2/30988 ,  A61F2/4455 ,  A61L27/44 ,  A61F2002/30995

摘要： Systems, methods, and devices for bony fusion are disclosed. A threaded cannulated implant may be inserted into a target space, such as in the sacroiliac joint. The implant may have a distal section, a proximal section, and a central section between the distal section and the proximal section. The distal section may comprise cutting threads and flutes for self-drilling the implant into bone. The proximal section may be configured to couple to an insertion instrument for the implant. The central section may have a lattice structure through which bone graft may flow to promote bone ingrowth. A solid core region may be located inwards from the lattice structure. The central section may also have openings through the core region to connect the lattice structure to the cannula.

公开(公告)号：US20230407556A1

公开(公告)日：2023-12-21

申请号：US18363846

申请日：2023-08-02

申请人： The Johns Hopkins University

发明人： Sung Hoon Kang ,  Santiago Orrego

IPC分类号： D06M10/04 ,  A61L27/44 ,  A61L27/50 ,  B32B33/00 ,  D01F1/10 ,  D01F6/12 ,  D06M16/00 ,  F16F15/00

CPC分类号： D06M10/04 ,  A61L27/44 ,  A61L27/50 ,  B32B33/00 ,  D10B2401/18 ,  D01F6/12 ,  D06M16/00 ,  F16F15/007 ,  D01F1/10

摘要： Self-adaptive systems, uses of the systems, and methods for adapting one or more properties of a material are disclosed.

公开(公告)号：US20230338626A1

公开(公告)日：2023-10-26

申请号：US18347181

申请日：2023-07-05

申请人： COOK MEDICAL TECHNOLOGIES LLC

发明人： John K. Jackson

IPC分类号： A61L31/16 ,  A61M25/09 ,  A61K31/58 ,  A61K31/436 ,  A61K31/353 ,  A61L31/10 ,  A61L29/16 ,  A61L29/08 ,  A61L27/54 ,  A61L27/44 ,  A61L27/34 ,  A61K31/337 ,  A61L31/08 ,  A61M25/10

CPC分类号： A61L31/16 ,  A61M25/09 ,  A61K31/58 ,  A61K31/436 ,  A61K31/353 ,  A61L31/10 ,  A61L29/16 ,  A61L29/085 ,  A61L27/54 ,  A61L27/44 ,  A61L27/34 ,  A61K31/337 ,  A61L31/08 ,  A61L29/08 ,  A61M25/10 ,  A61L2300/606 ,  H05K999/99 ,  A61M2025/105 ,  A61L2300/61 ,  A61L2300/426 ,  A61L2420/06 ,  A61L2300/416 ,  A61L2300/602

摘要： Various aspects of the present disclosure provide compositions including a water-insoluble therapeutic agent and a gallate-containing compound. Other aspects provide methods of using such compositions.

公开(公告)号：US11771807B2

公开(公告)日：2023-10-03

申请号：US16515946

申请日：2019-07-18

申请人： The Johns Hopkins University

发明人： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC分类号： A61L27/58 ,  A61L27/54 ,  A61L27/20 ,  A61L27/18 ,  A61L27/44 ,  A61L27/38 ,  A61L27/52 ,  A61M5/19 ,  A61L27/48 ,  A61L27/56 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/34 ,  A61M2202/08 ,  A61M2202/09 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US20230263941A1

公开(公告)日：2023-08-24

申请号：US18174327

申请日：2023-02-24

申请人： ThoraGenix Innovations, Inc.

发明人： Fotios M. ANDREOPOULOS

IPC分类号： A61L27/36 ,  A61L27/44 ,  A61L27/54 ,  A61L27/38

CPC分类号： A61L27/3608 ,  A61L27/365 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3821 ,  A61L27/44 ,  A61L27/54 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/418

摘要： Systems, methods, and devices include techniques for generating and using a demineralized bone matrix (DBM)-gelatin matrix allograft material. The DBM-gelatin material can be used to form an implant (e.g., for sternal closure operations) and/or a gel (e.g., for wound/fracture treatment). A method for forming the implant or bone graft can include forming the DBM from an initial bone material; and mixing, in a solution, the DBM with a gelatin carrier to form a DBM-gelatin solution. The gelatin carrier can include an animal-based collagen, such as a porcine-based collagen or a bovine-based collagen. Additionally, the method of forming the bone graft can include performing a crosslinking reaction with the DBM-gelatin solution. The implant can be packaged in a sterile hydration container prior to use.

公开(公告)号：US11707557B2

公开(公告)日：2023-07-25

申请号：US17591806

申请日：2022-02-03

申请人： COOK MEDICAL TECHNOLOGIES LLC

发明人： John K. Jackson

IPC分类号： A61L31/16 ,  A61K31/58 ,  A61K31/436 ,  A61L31/10 ,  A61L29/16 ,  A61L29/08 ,  A61L27/54 ,  A61L27/44 ,  A61L27/34 ,  A61K31/337 ,  A61L31/08 ,  A61M25/09 ,  A61K31/353 ,  A61M25/10

CPC分类号： A61L31/16 ,  A61K31/337 ,  A61K31/353 ,  A61K31/436 ,  A61K31/58 ,  A61L27/34 ,  A61L27/44 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L31/08 ,  A61L31/10 ,  A61M25/09 ,  A61M25/10 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/61 ,  A61L2420/06 ,  A61M2025/105 ,  H05K999/99

摘要： Various aspects of the present disclosure provide compositions including a water-insoluble therapeutic agent and a gallate-containing compound. Other aspects provide methods of using such compositions.

公开(公告)号：US11660182B2

公开(公告)日：2023-05-30

申请号：US17060901

申请日：2020-10-01

申请人： Alcon Inc.

发明人： Terah Whiting Smiley ,  Andrew R. Walz ,  Sharad Hajela ,  Gregory Vinton Matthews ,  Robert Angelopoulos ,  Nathan Lewis

IPC分类号： A61F2/16 ,  A61L27/44 ,  A61L27/50

CPC分类号： A61F2/1624 ,  A61F2/1605 ,  A61F2/1635 ,  A61F2/1659 ,  A61L27/44 ,  A61L27/443 ,  A61L27/50 ,  A61F2002/169 ,  A61F2002/1681 ,  A61F2002/16901 ,  A61F2230/0069 ,  A61F2250/0003 ,  A61L2300/204 ,  A61L2300/442 ,  A61L2430/16

摘要： Disclosed are adjustable accommodating intraocular lenses and methods of adjusting accommodating intraocular lenses post-operatively. In one embodiment, an adjustable accommodating intraocular lens comprises an optic portion and a peripheral portion. At least one of the optic portion and the peripheral portion can be made in part of a composite material comprising an energy absorbing constituent and a plurality of expandable components. At least one of a base power and a cylindricity of the optic portion can be configured to change in response to an external energy directed at the composite material.