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1.发明申请CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 有权CHROMEN-2-ONE衍生物及其作为单胺神经递质抑制剂的用途公开(公告)号：US20100056562A1
公开(公告)日：2010-03-04
申请号：US12615925
申请日：2009-11-10
IPC分类号： A61K31/439 , C07D221/02
CPC分类号： C07D405/12 , C07D451/06 , C07D451/12
摘要： This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型色烯-2-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3,8-SUBSTITUTED 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS](/abs-image/US/2010/07/29/US20100190821A1/abs.jpg.150x150.jpg)
2.发明申请3,8-SUBSTITUTED 8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES AND THEIR USE AS MONOMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS 失效3,8-取代的8-AZA-BICYCLO [3.2.1] OCTANE衍生物及其作为单体神经递质抑制剂的用途公开(公告)号：US20100190821A1
公开(公告)日：2010-07-29
申请号：US12727972
申请日：2010-03-19
申请人： Dan PETERS , Bjarne H. Dahl , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Jorgen Scheel-Kruger , John Paul Redrobe
发明人： Dan PETERS , Bjarne H. Dahl , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Jorgen Scheel-Kruger , John Paul Redrobe
IPC分类号： C07D451/02 , A61K31/46 , A61P25/00 , A61P25/24 , A61P25/28 , A61P25/18 , A61P25/06 , A61P25/30 , A61P29/00 , A61P13/00 , A61P15/00
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel 9-Aza-Bicyclo[3.3.1]Nonane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2007/10/04/US20070232641A1/abs.jpg.150x150.jpg)
3.发明申请Novel 9-Aza-Bicyclo[3.3.1]Nonane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 失效新型9-氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质重吸收抑制剂的用途公开(公告)号：US20070232641A1
公开(公告)日：2007-10-04
申请号：US11579056
申请日：2005-06-14
IPC分类号： C07D451/14 , A61K31/439 , A61P23/00
CPC分类号： C07D451/14
摘要： This invention relates to novel 9-aza-bicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型9-氮杂 - 双环[3.3.1]壬烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US07235548B2
公开(公告)日：2007-06-26
申请号：US10642224
申请日：2003-08-18
申请人： Alex Haaht Gouliaev , Mogens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Jorgen Scheel-Kruger , Gunnar M. Olsen , Elsesbet Ostergaard Nielsen
发明人： Alex Haaht Gouliaev , Mogens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Jorgen Scheel-Kruger , Gunnar M. Olsen , Elsesbet Ostergaard Nielsen
IPC分类号： C07D285/26 , C07D417/12 , A61K31/5415
CPC分类号： C07D417/04 , C07D239/90 , C07D285/24 , C07D285/28 , C07D513/04
摘要： The invention provides novel compounds represented by the general formula compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.
摘要翻译： 本发明提供了由下式表示的通式化合物表示的新化合物：其中由虚线表示的键可以是单键，双键或不存在; 并且如果该键不存在，则氮被氢和R 2取代; X表示SO 2或C-O或CH 2 2; Y表示-CH（R 4） - ， - N（R 4） - 或-N（R 4） - CH 2， - O; 并且R 2，R 3，R 4，R 5，R 6，R 6， R 7，R 7和R 8如申请中所定义。化合物可用作AMPA受体的阳性调节剂。
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公开(公告)号：US5444070A
公开(公告)日：1995-08-22
申请号：US93181
申请日：1993-07-16
IPC分类号： A61K31/46 , C07D451/02 , C07D413/04 , A61K31/44 , C07D401/04
CPC分类号： C07D451/02 , A61K31/46
摘要： The present invention discloses compounds of the formula ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sub.3, and R.sup.4 each have the meanings set forth in the specification.The compounds possess valuable pharmaceutical properties as dopamine reuptake inhibitors.
摘要翻译： 本发明公开了下式的化合物：其任何混合物，或其药学上可接受的盐; 其中R，R 3和R 4各自具有说明书中阐述的含义。 该化合物具有有价值的药物性质作为多巴胺再摄取抑制剂。
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6.发明授权Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US08410271B2
公开(公告)日：2013-04-02
申请号：US12615925
申请日：2009-11-10
IPC分类号： C07D401/00 , C07D225/00 , A61K31/00
CPC分类号： C07D405/12 , C07D451/06 , C07D451/12
摘要： This invention relates to chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的色烯-2-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3,8-substituted 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2011/08/02/US07989470B2/abs.jpg.150x150.jpg)
7.发明授权3,8-substituted 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效3,8-取代的8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07989470B2
公开(公告)日：2011-08-02
申请号：US12727972
申请日：2010-03-19
申请人： Dan Peters , Bjarne H. Dahl , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Jorgen Scheel-Kruger , John Paul Redrobe
发明人： Dan Peters , Bjarne H. Dahl , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Jorgen Scheel-Kruger , John Paul Redrobe
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3,8-Substituted 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2008/01/03/US20080004252A1/abs.jpg.150x150.jpg)
8.发明申请3,8-Substituted 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors 失效3,8-取代的8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单体神经递质重吸收抑制剂的用途公开(公告)号：US20080004252A1
公开(公告)日：2008-01-03
申请号：US11794365
申请日：2006-01-11
申请人： Dan Peters , Bjarne Dahl , Gunnar Olsen , Elsebet Nielsen , Jorgen Scheel-Kruger , John Redrobe
发明人： Dan Peters , Bjarne Dahl , Gunnar Olsen , Elsebet Nielsen , Jorgen Scheel-Kruger , John Redrobe
IPC分类号： A61K31/397 , A61P25/00 , C07D205/00
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US07199118B2
公开(公告)日：2007-04-03
申请号：US10489640
申请日：2002-10-02
申请人： Alex Haahr Gouliaev , Morgens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Karin Sandager Nielsen , Barbara Hartz , Jorgen Scheel-Kruger
发明人： Alex Haahr Gouliaev , Morgens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Karin Sandager Nielsen , Barbara Hartz , Jorgen Scheel-Kruger
IPC分类号： C07D417/04 , C07D417/14 , C07D279/34 , A61K31/5415
CPC分类号： C07D417/12 , C07D279/02
摘要： This invention relates to novel benzothiazine derivatives of Formula I useful as modulators of the AMPA sensitive glutamate receptors, pharmaceutical compositions comprising such compounds and their use in therapy.
摘要翻译： 本发明涉及可用作AMPA敏感谷氨酸受体的调节剂的式I的新的苯并噻嗪衍生物，其包含这些化合物的药物组合物及其在治疗中的用途。
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![Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2006/07/06/US20060148847A1/abs.jpg.150x150.jpg)
10.发明申请Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效新型8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20060148847A1
公开(公告)日：2006-07-06
申请号：US10543828
申请日：2004-02-10
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclo[[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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