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18 条记录 (耗时 0.017 秒)

    Directional use
    4.
    发明授权
    Directional use 有权

    公开(公告)号：US10092715B2

    公开(公告)日：2018-10-09

    申请号：US12440817

    申请日：2007-09-27

    申请人： Anders Axelsson ,  Karl Olov Fagerström

    发明人： Anders Axelsson ,  Karl Olov Fagerström

    IPC分类号： A61M31/00 ,  A61M15/00

    摘要： Disclosed is a method for oral administration of a liquid containing an active substance to a subject for improved absorption into the subject's bloodstream. It includes the steps of providing a delivery device containing the liquid and having a mouthpiece for directing the liquid in a defined direction during delivery; directing the mouthpiece toward a localized area of the subject's mouth being especially suitable for relatively increased uptake and relatively faster onset of action of the active substance; and delivering a measured amount of the liquid directly to the area using the device. Also disclosed is a spray device that includes a container capable of holding a liquid containing an active substance, and a mouthpiece constructed to dispense the liquid in a defined direction and directly to a localized area of a subject's mouth, the localized area being the oral vestibule.

    Snuff composition
    6.
    发明授权
    Snuff composition 有权

    公开(公告)号：US10219999B2

    公开(公告)日：2019-03-05

    申请号：US13690531

    申请日：2012-11-30

    申请人： Niconovum USA, Inc.

    发明人： Anders Axelsson ,  Arne Kristensen ,  Henri Hansson

    IPC分类号： A61K9/00 ,  A24B13/00 ,  A24B15/14 ,  A61K31/465 ,  A61K9/14

    摘要： Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.

    THERAPEUTIC COMPOSITION AND CONFIGURATION
    8.
    发明申请
    THERAPEUTIC COMPOSITION AND CONFIGURATION 审中-公开
    治疗组合物和配置

    公开(公告)号：US20170007594A1

    公开(公告)日：2017-01-12

    申请号：US14794026

    申请日：2015-07-08

    申请人： NICONOVUM USA, INC.

    发明人： August J. Borschke

    IPC分类号： A61K31/465 ,  A61K9/00 ,  A24F47/00

    CPC分类号： A61K31/465 ,  A24F47/00 ,  A61J7/003 ,  A61K9/0056

    摘要： A system intended to be employed for therapeutic purposes incorporates an active ingredient (e.g., a source of nicotine). Representative forms of nicotine include free base (e.g., as a mixture of nicotine and microcrystalline cellulose), a nicotine salt (e.g., as nicotine bitartrate) and nicotine polacrilex. The system preferably comprises a lozenge incorporating the active ingredient, adapted to provide oral administration of nicotine. The lozenge is in contact with a substrate (e.g., hollow tube) that can be manipulated within the mouth of the user (e.g., the hollow tube can be drawn upon to simulate the inhalation of cigarette smoke). As such, the active ingredient is administered and the user is able to experience certain other physiological sensations. The composition is useful for treatment of central nervous system conditions, diseases, and disorders, and can be used as a nicotine replacement therapy.

    摘要翻译： 旨在用于治疗目的的系统包含活性成分（例如，尼古丁来源）。 尼古丁的代表性形式包括游离碱（例如，作为尼古丁和微晶纤维素的混合物），尼古丁盐（例如，作为酒石酸烟碱）和尼古丁polacrilex。 该系统优选包含适合于提供口服施用尼古丁的活性成分的锭剂。 锭剂与可以在使用者口中操纵的衬底（例如，中空管）接触（例如，中空管可以被吸引以模拟吸入香烟烟雾）。 因此，施用活性成分并且使用者能够经历某些其他生理感觉。 该组合物可用于治疗中枢神经系统疾病和疾病，并可用作尼古丁替代疗法。