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公开(公告)号：US20220265911A1
公开(公告)日：2022-08-25
申请号：US17743655
申请日：2022-05-13
摘要： A method of controlling thermal transfer in a perfusion system heat exchanger of an extracorporeal fluid treatment device for conditioning an extracorporeal patient fluid for administration to a patient comprises a step of providing a perfusion system heat exchanger, wherein the perfusion system heat exchanger comprises a first fluid passage for a liquid heat transfer medium and a second fluid passage for the extracorporeal patient fluid to be temperature-controlled via exchange of thermal energy with the heat transfer medium, and a step of providing the heat transfer medium through the first fluid passage. The heat transfer medium comprises a component with anti-microbial properties, such as glycol. The provision of antimicrobial fluid reduces the risk of microbe contamination of the extracorporeal fluid, and hence the risk of clinical complications.
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公开(公告)号：US11241523B2
公开(公告)日：2022-02-08
申请号：US16472194
申请日：2017-12-19
发明人： Stephen Turner
摘要： A control system is provided to restrict the flow rate of blood in a venous line 12 of a perfusion system 1 comprising a reservoir 10 supplied by the venous line 12 and supplying an outgoing line 22. The control system comprises an outgoing flow sensor 32 configured to determine an outgoing flow value indicative of the outgoing flow rate in the outgoing line 22, and a controller configured to process the outgoing flow value and to determine if the outgoing flow value exceeds a pre-set pairing threshold. The system further comprises an adjustable restriction 28 for restricting the flow rate in the venous line 12 to maintain a venous flow rate that does not exceed a venous restriction threshold, wherein the adjustable restriction 28 is responsive to the controller and wherein the controller comprises a configuration allowing the controller to set the adjustable restriction at the level of the outgoing flow rate, to change the venous restriction threshold with the outgoing flow rate, if the outgoing flow value is above the pre-set pairing threshold.
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公开(公告)号：US11123470B2
公开(公告)日：2021-09-21
申请号：US15745896
申请日：2016-07-21
发明人： Stephen Turner
IPC分类号： A61M1/36 , A61M1/14 , A61M60/205 , A61M39/28
摘要： A cardioplegic agent delivery system comprises a supply reservoir (40) for a cardioplegic agent carrier fluid, a delivery channel from the supply reservoir (40) to an outlet (48), and a pump (50) to flow the carrier liquid in the delivery channel above a minimum driving pressure. The supply reservoir (40) is configured to hold carrier fluid below the minimum driving pressure. The pump (50) is a centrifugal pump configured to receive carrier fluid from the supply reservoir (40) and to flow the carrier fluid to the outlet (48) at a flow rate and above the minimum driving pressure for the delivery of cardioplegic agent. This allows cardioplegia delivery to be managed better.
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公开(公告)号：US11116961B2
公开(公告)日：2021-09-14
申请号：US15776653
申请日：2016-11-10
发明人： Stephen Turner
IPC分类号： A61M1/32 , A61M60/50 , A61M1/36 , A61M60/205 , A61M60/279
摘要： A control system in a blood line (12) of a cardiopulmonary bypass perfusion system (1) comprises a flow sensor (26) to determine a flow value indicative of the flow rate, a controller configured to process the flow value, and an adjustable restriction (28) responsive to the controller, to reduce the flow rate in the venous blood line (12) to maintain a flow rate to the venous blood reservoir that does not exceed a restriction threshold. As the adjustable restriction (28) is responsive to the flow sensor (26), this provides a closed loop control mechanism that avoids restricting the blood line (12) of the perfusion system (1) more than intended.
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公开(公告)号：US10953150B2
公开(公告)日：2021-03-23
申请号：US15575602
申请日：2016-05-17
发明人： Stephen Turner
IPC分类号： A61M1/36
摘要： A control system for controlling a quantity of blood in a blood reservoir (10) of a perfusion system supplied by a venous line (V), wherein a pump (20) circulates blood from the blood reservoir (10) through an outgoing line (A), comprises a venous flow sensor (22) to measure a venous blood flow rate, an outlet flow sensor (24) to measure an outgoing blood flow rate, and a controller to control the pump (20) to prevent the outgoing blood flow rate from exceeding the venous blood flow rate. Thereby, a decrease of blood in the blood reservoir (10) can be arrested.
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公开(公告)号：US11541158B2
公开(公告)日：2023-01-03
申请号：US15994315
申请日：2018-05-31
摘要： An exhaust gas flow control system for an oxygenator of an extracorporeal ventilation system connected to an oxygenation gas supply line and to an exhaust line for removal of exhaust gas comprises a flow control path, a pressure control path, an exhaust flow regulator responsive to the controller, and an exhaust gas pressure regulator responsive to a controller configured to maintain a pre-determined pressure level in the exhaust line. This provides a better degree of control over the pressure across the oxygenator from oxygenation gas inlet to exhaust.
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公开(公告)号：US20220323741A1
公开(公告)日：2022-10-13
申请号：US17835709
申请日：2022-06-08
发明人： Stephen Turner
IPC分类号： A61M39/28
摘要： A clamping mechanism (30) for clamping a flexible tube comprises two rotatable bobbins (22, 32), each with a tube-engaging surface portion (24) defining boundaries of: a free space through which a tube may extend. The shape of: the tube-engaging surface portion (24) changes around the bobbin circumference, such that axial rotation of the bobbins (22, 32) reduces the free space and thereby squeezes the tube. This allows the flow through the tube to be altered dependent on the rotation of: the bobbins.
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公开(公告)号：US20210316126A1
公开(公告)日：2021-10-14
申请号：US17284554
申请日：2019-10-02
发明人： Jeremy Tamari
IPC分类号： A61M39/02
摘要： The invention relates to a vascular access device (10) for implantation onto a vessel wall, the access device comprising an tubular structure (12) to provide an access passage into the vessel via a hole in a vessel wall, a connector arrangement (20; 21) for attaching the tubular structure at said hole in the vessel wall, and a membrane structure (16A; 16B) sufficiently flexible to be collapsed for insertion through said hole and to be expanded to lie at least partially against an inner vessel surface thereby to surround the hole. The membrane structure comprises a membrane aperture (18) to provide a passage from inside the vessel into the tubular structure. The vascular access device further comprises a closing mechanism capable of closing the membrane aperture while the membrane structure is expanded against said inner vessel surface. There is also provided a method of implanting a vascular access device.
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公开(公告)号：US10773071B2
公开(公告)日：2020-09-15
申请号：US15542235
申请日：2016-01-08
发明人： Stephen Turner
摘要： A clamp arrangement for retaining a flexible tube (18) during operation of a roller pump (10) for pumping fluid, the clamp arrangement comprising a pair of rotatable bobbins (24A, 24B, 26A, 26B) mounted adjacent to each other. Each bobbin (24A, 24B, 26A, 26B) has a tapered groove (30), formed partially around a cylindrical surface of the bobbin (24A, 24B, 26A, 26B), and counter rotation of the bobbins (24A, 24B, 26A, 26B) clamps the tube 18 between the bobbins (24A, 24B, 26A, 26B) in the tapered grooves (30). The clamp arrangement allows tubes of different shapes and diameters to be securely held without overly deforming the tube.
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公开(公告)号：US10556052B2
公开(公告)日：2020-02-11
申请号：US15532656
申请日：2015-12-03
发明人： Stephen Turner
摘要： A control system controlling blood gas values in blood processed by an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, comprises a monitoring arrangement to determine a level of the blood gas values in the arterial blood and a controller that is responsive to the monitoring arrangement and configured to control parameters of the oxygenation gas supply to the oxygenator. This allows the blood gas values to be adjusted toward a pre-determined level.
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