公开(公告)号：US10675269B2

公开(公告)日：2020-06-09

申请号：US16070925

申请日：2017-01-17

申请人： TRINUTRA LTD.

发明人： Yoram Sela ,  Mor Zeilkha ,  Itschak Lamensdorf

IPC分类号： A61K36/00 ,  A61K31/4045 ,  A61K31/185 ,  A61K36/185 ,  A61K31/191 ,  A61P25/20 ,  A61P25/22 ,  A61P29/00 ,  A61K9/00 ,  A61K31/192 ,  A61K36/84

摘要： The present invention provides a composition comprising a synergistic combination of melatonin, valerenic acid and carnosic acid. The composition may be used in the treatment and prevention of several different disorders including inflammatory conditions, sleep disorders and anxiety. The invention also relates to several dosage forms which are suitable for the delivery of the claimed composition to subjects in need of treatment therewith.

公开(公告)号：US20240165188A1

公开(公告)日：2024-05-23

申请号：US18526617

申请日：2023-12-01

申请人： TRINUTRA LTD.

发明人： Liki VON OPPEN-BEZALEL ,  Mor ZEILKHA

IPC分类号： A61K36/71 ,  A61K31/015 ,  A61K31/05 ,  A61K31/122 ,  A61K31/20 ,  A61P17/08 ,  A61P31/04 ,  A61P31/10

CPC分类号： A61K36/71 ,  A61K31/015 ,  A61K31/05 ,  A61K31/122 ,  A61K31/20 ,  A61P17/08 ,  A61P31/04 ,  A61P31/10 ,  A61K2236/31

摘要： The present invention is directed to a method for treating and/or preventing skin, mucosal and systemic conditions resulting from microbial overgrowth, imbalance or infections comprising administering a composition to a mammalian subject, wherein said composition comprises oil obtained from Nigella sativa seeds, and wherein said oil comprises thymoquinone at a concentration of at least 2.5% w/w and one or more free fatty acids (FFAs) at a concentration of 2.5% w/w or less. The present invention is also directed to dosage forms comprising the aforementioned composition.

公开(公告)号：US11426365B2

公开(公告)日：2022-08-30

申请号：US16631037

申请日：2018-07-15

申请人： TRINUTRA LTD.

发明人： Yoram Sela ,  Mor Zeilkha ,  Itschak Lamensdorf

IPC分类号： A61K36/00 ,  A61K31/122 ,  A61P29/00 ,  A61K31/202 ,  A61K31/404 ,  A61K36/53 ,  A61K36/71

摘要： The present invention provides a composition comprising a synergistic combination of thymoquinone and one or more omega-3 fatty acids, wherein the molar ratio between said thymoquinone and said one or more omega-3 fatty acids is at least 1:7. The present invention also provides a method of using said composition to treat or prevent inflammatory conditions.

公开(公告)号：US11266701B2

公开(公告)日：2022-03-08

申请号：US16188613

申请日：2018-11-13

申请人： TRINUTRA LTD.

发明人： Itschak Lamensdorf ,  Yoram Sela ,  Mor Zeilkha

IPC分类号： A61K36/16 ,  A61K36/77 ,  A61K9/20 ,  A61K31/137 ,  A61K31/522 ,  A61K36/258 ,  A61K36/484 ,  A61K45/06

摘要： The present invention provides a therapeutic composition comprising a synergistic combination of caffeine, Ginkgo biloba, and β-phenylethylamine (PEA) or its salt. The invention is also directed to oral dosage forms containing said composition, and to a method of treatment of a psychological, psychiatric, behavioral and/or neurodevelopmental disorder comprising the administration of said compositions and dosage forms to a patient in need thereof.

公开(公告)号：US20230102251A1

公开(公告)日：2023-03-30

申请号：US17897536

申请日：2022-08-29

申请人： TRINUTRA LTD.

发明人： Yoram SELA ,  Mor Zeilkha ,  Itschak Lamensdorf

IPC分类号： A61K31/122 ,  A61K31/202 ,  A61P29/00 ,  A61K31/404 ,  A61K36/71 ,  A61K36/53

摘要： The present invention provides a composition comprising a synergistic combination of thymoquinone and one or more omega-3 fatty acids, wherein the molar ratio between said thymoquinone and said one or more omega-3 fatty acids is at least 1:7. The present invention also provides a method of using said composition to treat or prevent inflammatory conditions.

公开(公告)号：US20190029999A1

公开(公告)日：2019-01-31

申请号：US16070925

申请日：2017-01-17

申请人： TRINUTRA LTD.

发明人： Yoram SELA ,  Mor ZEILKHA ,  Itschak LAMENSDORF

IPC分类号： A61K31/4045 ,  A61P25/20 ,  A61P25/22 ,  A61P29/00 ,  A61K9/00

CPC分类号： A61K31/4045 ,  A61K9/006 ,  A61K31/185 ,  A61K31/191 ,  A61K31/192 ,  A61K36/185 ,  A61K36/84 ,  A61K2300/00 ,  A61P25/20 ,  A61P25/22 ,  A61P29/00

摘要： The present invention provides a composition comprising a synergistic combination of melatonin, valerenic acid and carnosic acid. The composition may be used in the treatment and prevention of several different disorders including inflammatory conditions, sleep disorders and anxiety. The invention also relates to several dosage forms which are suitable for the delivery of the claimed composition to subjects in need of treatment therewith.

公开(公告)号：US10159702B2

公开(公告)日：2018-12-25

申请号：US15841830

申请日：2017-12-14

申请人： TRINUTRA LTD.

发明人： Itschak Lamensdorf ,  Yoram Sela ,  Mor Zeilkha

IPC分类号： A61K36/16 ,  A61K36/77 ,  A61K9/20 ,  A61K31/137 ,  A61K31/522 ,  A61K36/258 ,  A61K45/06 ,  A61K36/484

摘要： The present invention provides a therapeutic composition comprising a synergistic combination of caffeine, ginkgo biloba, and β-phenylethylamine (PEA) or its salt. The invention is also directed to oral dosage forms containing said composition, and to a method of treatment of a psychological, psychiatric, behavioral and/or neurodevelopmental disorder comprising the administration of said compositions and dosage forms to a patient in need thereof.