Pine Cone Extracts and Uses Thereof
    2.
    发明申请
    Pine Cone Extracts and Uses Thereof 审中-公开
    松果提取物及其用途

    公开(公告)号:US20090142833A1

    公开(公告)日:2009-06-04

    申请号:US12013193

    申请日:2008-01-11

    IPC分类号: C12N5/06

    摘要: A method of producing a pine cone extract and the pine cone extract produced there from, wherein the pine cone extract is useful in increasing the effects of nucleic acid vaccines and medicaments; and useful in the production of phenotypically immature and/or mature dendritic and/or fibrocyte cells.

    摘要翻译: 松树提取物的生产方法,松果提取物和松果提取物的生产方法,其中松果提取物可用于增加核酸疫苗和药物的作用; 并且可用于表型不成熟和/或成熟的树突状细胞和/或纤维细胞的生产。

    Method of enhancing the proliferative phase of a primary T cell response
    4.
    发明授权
    Method of enhancing the proliferative phase of a primary T cell response 有权
    增强原发性T细胞应答增殖期的方法

    公开(公告)号:US09211326B2

    公开(公告)日:2015-12-15

    申请号:US13958558

    申请日:2013-08-03

    摘要: Disclosed is an alkaline extract of shredded pinecones yields a polyphenylpropanoid polysaccharide complex (PPC) that functions as an orally active immune adjuvant. Specifically, the oral PPC boosts the number of antigen-specific memory CD8+ T cells generated in response to a variety of vaccine types (DNA, protein, and dendritic cell) and bias the response towards one that is predominately a T helper 1 type. The oral PPC has potential for use be to enhance the T cell response generated by a variety of prophylactic and therapeutic vaccines designed to target a cellular response.

    摘要翻译: 公开了切碎的松果的碱性提取物产生作为口服活性免疫佐剂的聚苯丙素多糖复合物(PPC)。 具体来说,口服PPC可以增加响应于各种疫苗类型(DNA,蛋白质和树突状细胞)产生的抗原特异性记忆CD8 + T细胞的数量,并将反应偏向主要是T辅助1型的反应。 口服PPC具有用于增强由旨在靶向细胞反应的各种预防和治疗疫苗产生的T细胞应答的潜力。

    METHOD OF ENHANCING THE PROLIFERATIVE PHASE OF A PRIMARY T CELL RESPONSE
    5.
    发明申请
    METHOD OF ENHANCING THE PROLIFERATIVE PHASE OF A PRIMARY T CELL RESPONSE 有权
    增加主要细胞应答的增殖阶段的方法

    公开(公告)号:US20150037373A1

    公开(公告)日:2015-02-05

    申请号:US13958558

    申请日:2013-08-03

    IPC分类号: A61K39/39 A61K39/085

    摘要: Disclosed is an alkaline extract of shredded pinecones yields a polyphenylpropanoid polysaccharide complex (PPC) that functions as an orally active immune adjuvant. Specifically, the oral PPC boosts the number of antigen-specific memory CD8+ T cells generated in response to a variety of vaccine types (DNA, protein, and dendritic cell) and bias the response towards one that is predominately a T helper 1 type. The oral PPC has potential for use be to enhance the T cell response generated by a variety of prophylactic and therapeutic vaccines designed to target a cellular response.

    摘要翻译: 公开了切碎的松果的碱性提取物产生作为口服活性免疫佐剂的聚苯丙素多糖复合物(PPC)。 具体来说,口服PPC可以增加响应于各种疫苗类型(DNA,蛋白质和树突状细胞)产生的抗原特异性记忆CD8 + T细胞的数量,并将反应偏向主要是T辅助1型的反应。 口服PPC具有用于增强由旨在靶向细胞反应的各种预防和治疗疫苗产生的T细胞应答的潜力。

    Pine cone extracts and uses thereof
    7.
    发明授权
    Pine cone extracts and uses thereof 有权
    松锥提取物及其用途

    公开(公告)号:US07838052B2

    公开(公告)日:2010-11-23

    申请号:US12099628

    申请日:2008-04-08

    IPC分类号: A61K36/13 A61K36/00

    摘要: A method of producing a pine cone extract and the pine cone extract produced there from, wherein the pine cone extract is useful in increasing the effects of nucleic acid vaccines and medicaments; and useful in the production of phenotypically immature and/or mature dendritic and/or fibrocyte cells.

    摘要翻译: 松树提取物的生产方法,松果提取物和松果提取物的生产方法,其中松果提取物可用于增加核酸疫苗和药物的作用; 并且可用于表型不成熟和/或成熟的树突状细胞和/或纤维细胞的生产。

    Pine cone extracts and uses thereof
    9.
    发明授权
    Pine cone extracts and uses thereof 失效
    松锥提取物及其用途

    公开(公告)号:US07371417B2

    公开(公告)日:2008-05-13

    申请号:US11010976

    申请日:2004-12-13

    IPC分类号: A01N65/00

    摘要: A method of producing a pine cone extract and the pine cone extract produced there from, wherein the pine cone extract is useful in increasing the effects of nucleic acid vaccines and medicaments; and useful in the production of phenotypically immature and/or mature dendritic and/or fibrocyte cells.

    摘要翻译: 松树提取物的生产方法,松果提取物和松果提取物的生产方法,其中松果提取物可用于增加核酸疫苗和药物的作用; 并且可用于表型不成熟和/或成熟的树突状细胞和/或纤维细胞的生产。