公开(公告)号：US09151755B2

公开(公告)日：2015-10-06

申请号：US14174815

申请日：2014-02-06

申请人： David H. Walker ,  Sunil Thomas

发明人： David H. Walker ,  Sunil Thomas

IPC分类号： G01N33/53 ,  G01N33/569 ,  A61K39/02 ,  C07K14/29 ,  C07K16/12 ,  A61K38/00 ,  A61K39/00

CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/6081 ,  C07K14/29 ,  C07K16/1246 ,  C07K2317/34 ,  Y02A50/403

摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.

摘要翻译： 本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。 本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。 本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。 本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。