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32 条记录 (耗时 0.019 秒)

    Methods for detecting Ehrlichia infection
    1.
    发明授权
    Methods for detecting Ehrlichia infection 有权
    检测埃里克病毒感染的方法

    公开(公告)号：US09151755B2

    公开(公告)日：2015-10-06

    申请号：US14174815

    申请日：2014-02-06

    申请人： David H. Walker ,  Sunil Thomas

    发明人： David H. Walker ,  Sunil Thomas

    IPC分类号： G01N33/53 ,  G01N33/569 ,  A61K39/02 ,  C07K14/29 ,  C07K16/12 ,  A61K38/00 ,  A61K39/00

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/6081 ,  C07K14/29 ,  C07K16/1246 ,  C07K2317/34 ,  Y02A50/403

    摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.

    摘要翻译： 本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。 本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。 本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。 本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。

    Compositions of and method of using heat shock protein peptides
    3.
    发明授权
    Compositions of and method of using heat shock protein peptides 有权
    使用热休克蛋白肽的组成和方法

    公开(公告)号：US08685406B2

    公开(公告)日：2014-04-01

    申请号：US12927220

    申请日：2010-11-10

    申请人： David H. Walker ,  Sunil Thomas

    发明人： David H. Walker ,  Sunil Thomas

    IPC分类号： A61K39/02 ,  C07K16/00

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/6081 ,  C07K14/29 ,  C07K16/1246 ,  C07K2317/34 ,  Y02A50/403

    摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.

    摘要翻译： 本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。 本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。 本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。 本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。

    Methods for detecting Ehrlichia infection
    5.
    发明授权
    Methods for detecting Ehrlichia infection 有权
    检测埃里克病毒感染的方法

    公开(公告)号：US09568473B2

    公开(公告)日：2017-02-14

    申请号：US14851747

    申请日：2015-09-11

    申请人： David H. Walker ,  Sunil Thomas

    发明人： David H. Walker ,  Sunil Thomas

    IPC分类号： G01N33/53 ,  G01N33/569 ,  A61K39/02 ,  C07K14/29 ,  C07K16/12 ,  A61K38/00 ,  A61K39/00

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/6081 ,  C07K14/29 ,  C07K16/1246 ,  C07K2317/34 ,  Y02A50/403

    摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.

    摘要翻译： 本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。 本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。 本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。 本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。

    Methods for Detecting Ehrlichia Infection
    6.
    发明申请
    Methods for Detecting Ehrlichia Infection 有权
    检测Ehrlichia感染的方法

    公开(公告)号：US20140273026A1

    公开(公告)日：2014-09-18

    申请号：US14174815

    申请日：2014-02-06

    申请人： David H. Walker ,  Sunil Thomas

    发明人： David H. Walker ,  Sunil Thomas

    IPC分类号： G01N33/569 ,  C07K14/29 ,  C07K16/12

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/6081 ,  C07K14/29 ,  C07K16/1246 ,  C07K2317/34 ,  Y02A50/403

    摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.

    摘要翻译： 本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。 本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。 本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。 本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。

    Method of diagnosing and treating Ehrlichia
    8.
    发明申请
    Method of diagnosing and treating Ehrlichia 有权
    诊断和治疗埃里氏杆菌的方法

    公开(公告)号：US20110117130A1

    公开(公告)日：2011-05-19

    申请号：US12927220

    申请日：2010-11-10

    申请人： David H. Walker ,  Sunil Thomas

    发明人： David H. Walker ,  Sunil Thomas

    IPC分类号： A61K39/02 ,  C07K14/00 ,  A61K38/16 ,  C07K16/00 ,  A61P31/04 ,  A61P37/04 ,  G01N33/53

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/0233 ,  A61K2039/6081 ,  C07K14/29 ,  C07K16/1246 ,  C07K2317/34 ,  Y02A50/403

    摘要： The present invention provides an isolated and purified heat shock protein 60 (Hsp60) peptide having the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a vaccine against Ehrlichia comprising a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to an antibody directed against a peptide homologous to the amino acid sequence of SEQ ID NO:2. The instant invention is also directed to a method of determining whether a subject is infected with Ehrlichia, comprising the steps of: contacting a sample from a subject with the antibody described herein; and detecting a resulting antibody reaction, wherein a positive reaction indicates the subject is infected with Ehrlichia.

    摘要翻译： 本发明提供了具有SEQ ID NO：2的氨基酸序列的分离和纯化的热休克蛋白60（Hsp60）肽。 本发明还涉及包含与SEQ ID NO：2的氨基酸序列同源的肽的抗埃利亚氏疫苗。 本发明还涉及针对与SEQ ID NO：2的氨基酸序列同源的肽的抗体。 本发明还涉及一种确定受试者是否感染埃里希氏菌的方法，包括以下步骤：使来自受试者的样品与本文所述的抗体接触; 并检测所得的抗体反应，其中阳性反应表明受试者被埃里希氏杆菌感染。

    Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof
    9.
    发明授权
    Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof 失效
    Ehrlichia canis的同源28千道尔顿免疫显性蛋白基因及其用途

    公开(公告)号：US07309583B2

    公开(公告)日：2007-12-18

    申请号：US10062920

    申请日：2002-01-31

    申请人： David H. Walker ,  Xue-Jie Yu ,  Jere W. McBride

    发明人： David H. Walker ,  Xue-Jie Yu ,  Jere W. McBride

    IPC分类号： C12P21/06 ,  C07K14/00

    CPC分类号： C07K14/29 ,  A61K39/00 ,  A61K2039/52 ,  Y02A50/403

    摘要： The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family of Ehrlichia canis. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes of Ehrlichia canis. Recombinant Ehrlichia canis 28-kDa proteins react with convalescent phase antiserum from an E. canis-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.

    摘要翻译： 本发明涉及来自多态性多基因家族的同源免疫反应性28-kDa蛋白基因p28-1，-2，-3，-5，-6，-7，-9的克隆，测序和表达 艾氏杆菌 进一步披露的是编码所有9个同源的28-kDa蛋白质基因的多基因位点。 重组埃氏杆菌28-kDa蛋白质与来自犬属感染狗的恢复期抗血清反应，并且可用于开发对疾病预防和血清诊断特别有效的疫苗和血清学诊断。