公开(公告)号：US08282968B2

公开(公告)日：2012-10-09

申请号：US11992927

申请日：2006-08-30

Applicant: Mahabir Prashad Kaushik ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Sanjay Kumar ,  Krishnamurthy Sekhar ,  Hemant Kumar Gogoi ,  Deba Koch

Inventor： Mahabir Prashad Kaushik ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Sanjay Kumar ,  Krishnamurthy Sekhar ,  Hemant Kumar Gogoi ,  Deba Koch

IPC: A01N65/00

CPC classification number: A61K36/53 ,  Y02A50/411

Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.

Abstract translation: 本发明涉及一种从印度东北部通常发现的名为Gomphostema niveum的草本叶获得的新型生物活性水分，其可用于抑制恶性疟原虫恶性疟原虫的生长。 本发明还涉及提取所述生物活性级分的方法。 本发明还提供了使用这种生物活性水部分治疗疟疾的方法以及使用这种生物活性水部分来治疗疟疾。

公开(公告)号：US20130052287A1

公开(公告)日：2013-02-28

申请号：US13400921

申请日：2012-02-21

Applicant: Mahabir Prashad KAUSHIK ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Sanjay Kumar ,  Krishnamurthy Sekhar ,  Hemant Kumar Gogoi ,  Deba Koch

Inventor： Mahabir Prashad KAUSHIK ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Sanjay Kumar ,  Krishnamurthy Sekhar ,  Hemant Kumar Gogoi ,  Deba Koch

IPC: A61K36/53 ,  A61P33/06

CPC classification number: A61K36/53 ,  Y02A50/411

Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.

Abstract translation: 本发明涉及一种从印度东北部通常发现的名为Gomphostema niveum的草本叶获得的新型生物活性水分，其可用于抑制恶性疟原虫恶性疟原虫的生长。 本发明还涉及提取所述生物活性级分的方法。 本发明还提供了使用这种生物活性水部分治疗疟疾的方法以及使用这种生物活性水部分来治疗疟疾。

公开(公告)号：US08241645B2

公开(公告)日：2012-08-14

申请号：US11992932

申请日：2006-10-04

Applicant: Mustoori Sairam ,  Anju Bansal ,  Sarada S. Surya Kumari ,  Piyush Paliwal

Inventor： Mustoori Sairam ,  Anju Bansal ,  Sarada S. Surya Kumari ,  Piyush Paliwal

IPC: A61K39/112 ,  A61K38/00 ,  C12N1/00

CPC classification number: C07K14/255 ,  A61K47/646

Abstract: A typhoid vaccine using heat shock protein (Hsp) of Salmonella typhi and a method for the manufacture thereof. A composition comprising an effective amount of a complex of a Hsp, in part or whole, either alone or covalently or non-covalently bound to an antigenic molecule, which when administered to a mammal elicits specific immunological responses in the host. The antigenic molecule refers to the exogenous antigens/immunogens such as viz LPS, peptide, nucleic acid or polysaccharide or antigenic/immunogenic fragments and derivatives thereof.

Abstract translation: 使用伤寒沙门氏菌的热休克蛋白（Hsp）的伤寒疫苗及其制造方法。 一种组合物，其包含有效量的Hsp复合物，其部分或全部单独或共价或非共价结合于抗原分子，其在施用于哺乳动物时在宿主中引发特异性免疫应答。 抗原分子是指外源抗原/免疫原，例如LPS，肽，核酸或多糖或其抗原/免疫原性片段及其衍生物。

公开(公告)号：US08951581B2

公开(公告)日：2015-02-10

申请号：US13400921

申请日：2012-02-21

Applicant: Mahabir Prashad Kaushik ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Sanjay Kumar ,  Krishnamurthy Sekhar ,  Hemant Kumar Gogoi ,  Deba Koch

Inventor： Mahabir Prashad Kaushik ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Sanjay Kumar ,  Krishnamurthy Sekhar ,  Hemant Kumar Gogoi ,  Deba Koch

IPC: A01N65/00 ,  A61K36/53

CPC classification number: A61K36/53 ,  Y02A50/411

Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.

Abstract translation: 本发明涉及一种从印度东北部通常发现的名为Gomphostema niveum的草本叶获得的新型生物活性水分，其可用于抑制恶性疟原虫恶性疟原虫的生长。 本发明还涉及提取所述生物活性级分的方法。 本发明还提供了使用这种生物活性水部分治疗疟疾的方法以及使用这种生物活性水部分来治疗疟疾。

公开(公告)号：US08188303B2

公开(公告)日：2012-05-29

申请号：US11992934

申请日：2006-08-30

Applicant: Mahabir Prashad Kaushik ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Badri Narayan Acharya ,  Subramaniam Prasanna ,  Krishnamurthy Sekhar

Inventor： Mahabir Prashad Kaushik ,  Duraipandian Thavaselvam ,  Manisha Nivsarkar ,  Badri Narayan Acharya ,  Subramaniam Prasanna ,  Krishnamurthy Sekhar

IPC: C07D307/02 ,  A01N43/08

CPC classification number: A61K36/53 ,  C07D307/32 ,  C07D307/33 ,  Y02A50/411

Abstract: The present invention provides an antimalarial compound 3-[2-(2-Hydroxymethyl-1,4a,5-trimethyl-7-oxo-1,2,3,4,4a,7 8,8a-octahydronaphthalen-1-yl)-ethyl]-5H-furan-2-one of the formula 1 given below or pharmaceutically acceptable derivatives thereof, isolated from Gomphostema niveum and also provides a method for the extraction thereof as well as methods for the treatment of malaria using said compound.

Abstract translation: 本发明提供抗疟药化合物3- [2-（2-羟甲基-1,4a，5-三甲基-7-氧代-1,2,3,4,4a，7,8,8a-八氢萘-1-基） - 乙基] -5H-呋喃-2-酮或其药学上可接受的衍生物，从Gomphostema niveum分离，并提供其提取方法以及使用所述化合物治疗疟疾的方法。