公开(公告)号：US20240033365A1

公开(公告)日：2024-02-01

申请号：US18224879

申请日：2023-07-21

Applicant: University of South Alabama

Inventor： Andrew E. Byrd ,  Robert A. Barrington

IPC: A61K47/64 ,  A61K45/06

CPC classification number: A61K47/64 ,  A61K45/06

Abstract: Described are the compounds, compositions and methods of treating diseases and disorders characterized by Formyl Peptide Receptor 1 (FPR1) or FPR2 activity.

公开(公告)号：US11612619B2

公开(公告)日：2023-03-28

申请号：US16672185

申请日：2019-11-01

Applicant: University of South Alabama Foundation for Research and Commercialization

Inventor： Richard Eric Honkanen ,  Brandon Marshall D'Arcy ,  Mark Raymond Swingle

IPC: A61K35/17 ,  C12N15/52 ,  C12N15/62 ,  C12N5/0783 ,  C12N9/02 ,  C12N9/04

Abstract: Compositions, methods, and systems for modifying sterol metabolism in a subject is disclosed. In some embodiments, the subjects may be administered one or more mammalian cells modified to express at least one sterol degrading enzyme derived from a bacterium. In many embodiments, the cell is a macrophage or monocyte stably expressing three or more enzymes that aid in opening the β ring of cholesterol. The disclosed compositions and methods may be useful in lowering cholesterol levels in a subject in need thereof. In some embodiments, the subject may have a genetic predisposition to atherosclerosis.

公开(公告)号：US11186534B2

公开(公告)日：2021-11-30

申请号：US16495013

申请日：2018-03-16

Applicant: University of South Alabama

Inventor： Gary Piazza ,  Xi Chen ,  Herbert Weissbach ,  Shailaja Kesraju Allani

IPC: C07C59/72 ,  A61P9/10

Abstract: The disclosure provides chemical compounds possessing therapeutic and/or protective properties against oxidative damage. Methods of making such therapeutic and/or protective compounds and associated compositions are also provided, as are methods for their use, which include protecting cells from oxidative damage and/or inhibiting production of ROS in a cell or subject, as well as preventing or reducing the extent of tissue damage caused by an ischemic event in a subject at elevated risk of such an event.

公开(公告)号：US20210275029A1

公开(公告)日：2021-09-09

申请号：US16382819

申请日：2017-10-12

Applicant: University of South Alabama

Inventor： Fabien Gabriel Eyal ,  Om Prakash Jha

IPC: A61B5/01 ,  A61B5/00 ,  A61B5/318 ,  A61B5/271

Abstract: A new born temperature and heart monitor wrap apparatus and method includes a wrap where the wrap is configured such that a new born is substantially covered by the wrap when the wrap is applied to the new born. A heart monitor device is attached to the wrap and a temperature lead retainer is attached to the wrap. A substrate is provided where the wrap is removably connected to the substrate.

公开(公告)号：US20210123087A1

公开(公告)日：2021-04-29

申请号：US17076130

申请日：2020-10-21

Applicant: University of South Alabama

Inventor： Terrence J. Ravine

IPC: C12Q1/18

Abstract: A method for testing a sample for antimicrobial activity is disclosed. The method includes: (a) inoculating the sample with a pigment-competent microorganism; (b) incubating the sample at an incubation temperature for an incubation time period sufficient for growth of the pigment-competent microorganism and for pigment production; and (c) detecting the presence or absence of the pigment-competent microorganism on or in the sample. The method employs an easy-to-interpret color development approach to detect antimicrobial activity of sample materials such as biocidal fabrics.

公开(公告)号：US10039764B2

公开(公告)日：2018-08-07

申请号：US14904632

申请日：2014-07-11

Applicant: University of South Alabama

Inventor： Gary A. Piazza

IPC: A61K31/415 ,  A61K31/4155 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/4409 ,  A61K31/519 ,  A61K31/472 ,  A61K31/517 ,  A61K45/06 ,  C12Q1/6886 ,  G01N33/574

Abstract: Disclosed are methods for treating cancer and precancerous conditions with PDE10A specific inhibitors and diagnosis of neoplastic diseases based on elevated levels of PDE10A.

公开(公告)号：US09901863B2

公开(公告)日：2018-02-27

申请号：US14541431

申请日：2014-11-14

Applicant: Chevron U.S.A. Inc. ,  University of South Alabama

Inventor： Daniel Chinn ,  Russell Evan Cooper ,  Zunqing He ,  James H. Davis, Jr. ,  Kevin N. West ,  Hye Kyung Timken ,  Michael S. Driver

IPC: B01D53/14

CPC classification number: B01D53/1493 ,  B01D53/1425 ,  B01D53/1456 ,  B01D53/1475 ,  B01D53/1481 ,  B01D2252/103 ,  B01D2252/30 ,  B01D2258/0233 ,  B01D2258/025 ,  B01D2258/0283 ,  Y02A50/2342 ,  Y02C10/04 ,  Y02C10/06

Abstract: A process and system for separating CO2 from a flue gas stream is disclosed. The process involves (a) contacting a flue gas stream containing water vapor and CO2 with an ionic absorbent under absorption conditions to absorb at least a portion of the CO2 from the flue gas stream and form a CO2-absorbent complex; wherein the ionic absorbent comprises a cation and an anion comprising an amine moiety; and (b) recovering a gaseous product having a reduced CO2 content.

公开(公告)号：US09840718B2

公开(公告)日：2017-12-12

申请号：US14904625

申请日：2014-07-11

Applicant: University of South Alabama

Inventor： Victor Solodushko ,  Brian Fouty ,  Vira Bitko

IPC: C12N15/86 ,  C12N15/11 ,  C12N15/12 ,  C12N15/85 ,  C12N9/12

CPC classification number: C12N15/85 ,  C12N9/1241 ,  C12Y207/07

Abstract: Disclosed are genetic delivery systems that utilize genetic elements of the piggyBac family transposon system, and methods of introducing nucleic acid into target cells using the genetic delivery systems.

公开(公告)号：US09267934B2

公开(公告)日：2016-02-23

申请号：US13881695

申请日：2011-10-25

Applicant: Seema Singh ,  Ajay P. Singh

Inventor： Seema Singh ,  Ajay P. Singh

IPC: A61K31/395 ,  G01N33/50 ,  A61K31/7088 ,  A61K31/7105

CPC classification number: A61K31/395 ,  A61K31/7088 ,  A61K31/7105 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/502

Abstract: Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the CXCR4 receptor and the CXCL12 ligand.

Abstract translation: 本发明的实施方案包括用于改善癌症的方法和组合物。 一些实施方案包括用于改善靶向CXCR4受体和CXCL12配体的胰腺癌的方法和组合物。

公开(公告)号：US20140080760A1

公开(公告)日：2014-03-20

申请号：US14117832

申请日：2012-05-16

Applicant: Hung T. Khong

Inventor： Hung T. Khong

IPC: A61K47/48 ,  A61K31/704 ,  A61K31/675 ,  A61K31/337

CPC classification number: A61K47/643 ,  A61K31/337 ,  A61K31/436 ,  A61K31/675 ,  A61K31/704 ,  A61K38/193 ,  A61K45/06 ,  A61K47/6929 ,  A61K2300/00

Abstract: The present invention relates to methods and compositions for the treatment of cancer. Some embodiments include methods of treating cancer comprising administering a chemotherapeutic agent associated with albumin, administering a second chemotherapeutic agent; and administering a third chemotherapeutic agent.

Abstract translation: 本发明涉及治疗癌症的方法和组合物。 一些实施方案包括治疗癌症的方法，包括施用与白蛋白相关的化学治疗剂，施用第二化学治疗剂; 和施用第三化学治疗剂。