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    SiRNA compositions and methods for potently inhibiting viral infection
    1.
    发明授权
    SiRNA compositions and methods for potently inhibiting viral infection 有权
    SiRNA组合物和有效抑制病毒感染的方法

    公开(公告)号：US08828962B2

    公开(公告)日：2014-09-09

    申请号：US13323364

    申请日：2011-12-12

    申请人： Bojian Zheng ,  Hongyan Sui ,  Yongping Lin

    发明人： Bojian Zheng ,  Hongyan Sui ,  Yongping Lin

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K31/7105 ,  C12N15/11 ,  C12N15/113 ,  C12Q1/68

    CPC分类号： A61K31/713 ,  A61K31/7105 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2320/10

    摘要： No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of β-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.

    摘要翻译： 没有抗病毒方案一直在治疗H5N1病毒感染成功。 我们证明一组针对不同H5N1病毒基因的高效siRNA共享独特的基序GGAGU / ACUCC。 我们进一步证明含有该基序的siRNA的有效性不是序列特异性的。 结果表明，独特基序的结构对于确定siRNA介导的针对病毒感染的保护作用的效力至关重要，并且这种有效的体内保护与由该基序诱导的早期产生的 - 防御素和IL-6相关。 提供了除了H5N1流感病毒之外还可用于其它病毒感染的方法和预防和治疗剂。

    Peptides having activity of inhibiting infections of respiratory viruses and use of the same
    2.
    发明授权
    Peptides having activity of inhibiting infections of respiratory viruses and use of the same 有权
    具有抑制呼吸道病毒感染的活性的肽及其用途

    公开(公告)号：US09464123B2

    公开(公告)日：2016-10-11

    申请号：US13999393

    申请日：2014-02-21

    申请人： Xiangxue Group (Hong Kong) Company Limited

    发明人： Bojian Zheng ,  Hanjun Zhao

    IPC分类号： C07K14/47 ,  G01N33/68 ,  A61K38/17 ,  G01N33/50 ,  A61K38/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K38/1709 ,  C07K14/4723 ,  G01N33/502 ,  G01N33/6845 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2500/10

    摘要： Peptides having activity of inhibiting infections of respiratory viruses and use of the same are disclosed. The peptides can be synthesized by chemical or genetic engineering methods, and they have functional domain capable of binding to surface glycoprotein of respiratory viruses and activity of inhibiting infections of respiratory viruses. The peptides are useful for blocking infections of respiratory viruses in target cells, for prevention/treatment of said infections, and for development of new prophylactic/therapeutic medicaments against respiratory viruses. Also disclosed are a kit for screening peptide capable of inhibiting said infections and the screening method. The invention also discloses the mechanism of the peptides in inhibition of said infections, which provides theory support for developing new prophylactic/therapeutic agents with broad-spectrum antiviral activities.

    摘要翻译： 公开了具有抑制呼吸道病毒感染的活性的肽及其用途。 肽可以通过化学或基因工程方法合成，并且它们具有能够结合呼吸道病毒的表面糖蛋白的功能结构域和抑制呼吸道病毒感染的活性。 所述肽可用于阻断靶细胞中呼吸道病毒的感染，用于预防/治疗所述感染，以及开发针对呼吸道病毒的新的预防/治疗药物。 还公开了用于筛选能够抑制所述感染的肽和筛选方法的试剂盒。 本发明还公开了肽在抑制所述感染中的机制，其为开发具有广谱抗病毒活性的新的预防/治疗剂提供理论支持。

    siRNA compositions and methods for potently inhibiting viral infection
    3.
    发明授权
    siRNA compositions and methods for potently inhibiting viral infection 有权
    siRNA组合物和有效抑制病毒感染的方法

    公开(公告)号：US08664188B2

    公开(公告)日：2014-03-04

    申请号：US12636234

    申请日：2009-12-11

    申请人： Bojian Zheng ,  Hongyan Sui ,  Yongping Lin

    发明人： Bojian Zheng ,  Hongyan Sui ,  Yongping Lin

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： A61K31/713 ,  A61K31/7105 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2320/10

    摘要： No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of β-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.

    摘要翻译： 没有抗病毒方案一直在治疗H5N1病毒感染成功。 我们证明一组针对不同H5N1病毒基因的高效siRNA共享独特的基序GGAGU / ACUCC。 我们进一步证明含有该基序的siRNA的有效性不是序列特异性的。 结果表明，独特基序的结构对于确定siRNA介导的针对病毒感染的保护作用的效力至关重要，并且这种有效的体内保护与由该基序诱导的β-防御素和IL-6的早期产生相关。 提供了除了H5N1流感病毒之外还可用于其它病毒感染的方法和预防和治疗剂。