公开(公告)号：US20240181054A1

公开(公告)日：2024-06-06

申请号：US18550205

申请日：2022-03-14

申请人： Synthego Corporation

发明人： Robert DEANS ,  Travis MAURES ,  Yueting ZHENG ,  Jared Carlson STEVERMER ,  Monique DAO ,  Phillip BALZANO ,  Rebecca NUGENT

IPC分类号： A61K39/00 ,  C07K14/74 ,  C12N5/0781 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC分类号： A61K39/4622 ,  A61K39/4612 ,  A61K39/4634 ,  A61K39/464491 ,  C07K14/70539 ,  C12N5/0635 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C07K2319/40 ,  C12N2310/20 ,  C12N2510/00 ,  C12N2800/80

摘要： The application relates to biological components, methods, systems, and kits for modulating immune responses. The disclosed biological components include genetically modified cells comprising an inserted exogenous sequence in a major histocompatibility complex (MHC)-associated gene. The inserted exogenous sequence encodes a peptide and the genetically modified cells express a fusion protein comprising the peptide and at least a portion of the polypeptide encoded by the MHC-associated gene to form a modified MHC complex. The genetically modified cells may present the peptide as an antigen associated with the MHC complex and may be utilized in methods for modulating T cell activity, inducing an immune response, and inducing a tolerogenic response. As such, the disclosed biological components, methods, systems, and kits may be utilized in order to treat and/or prevent a disease or disorder in a subject in need thereof and to screen and validate clinically relevant antigens.

公开(公告)号：US20230405118A1

公开(公告)日：2023-12-21

申请号：US18251060

申请日：2021-10-29

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION

发明人： Alejandro VILLAGRA ,  Satish NOONEPALLE ,  Maria del Mar Gracia HERNANDEZ

IPC分类号： A61K39/00 ,  C12N5/0786 ,  A61K35/15 ,  A61K45/06

CPC分类号： A61K39/4614 ,  C12N5/0645 ,  A61K39/464495 ,  A61K39/464491 ,  A61K39/464486 ,  A61K39/464488 ,  A61K39/46449 ,  A61K39/464482 ,  A61K39/464481 ,  A61K39/46447 ,  A61K39/464456 ,  A61K39/464451 ,  A61K39/4644 ,  A61K35/15 ,  A61K45/06 ,  C12N2501/2304 ,  C12N2501/2313 ,  A61K2039/5154

摘要： The present disclosure provides signal transducer and activator of transcription (STAT)-activated macrophages, compositions comprising STAT-activated macrophages, methods of making STAT-activated macrophages, and methods of treating diseases, e.g., cancer, by administering a therapeutically effective amount of STAT-activated macrophages.