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31 条记录 (耗时 0.028 秒)

    Buprenorphine derivatives and uses thereof
    3.
    发明授权
    Buprenorphine derivatives and uses thereof 有权
    丁丙诺啡衍生物及其用途

    公开(公告)号：US07964610B2

    公开(公告)日：2011-06-21

    申请号：US12294462

    申请日：2007-03-27

    申请人： John William Lewis ,  Christopher Bourne Chapleo

    发明人： John William Lewis ,  Christopher Bourne Chapleo

    IPC分类号： A61K31/4748 ,  C07D491/08

    CPC分类号： C07D498/12

    摘要： Ester derivatives of the phenolic hydroxyl group of buprenorphine can be used in the treatment of opiate dependency and/or moderate to severe pain. The esters have an enhanced bioavailability, an enhanced duration of action, and a reduced abuse potential.

    摘要翻译： 丁丙诺啡的酚羟基的酯衍生物可用于治疗阿片依赖性和/或中度至重度疼痛。 酯类具有增强的生物利用度，增强的作用持续时间和减少的滥用潜力。

    Monoclonal antibodies specific for buprenorphine and metabolites thereof
    4.
    发明授权
    Monoclonal antibodies specific for buprenorphine and metabolites thereof 有权
    对丁丙诺啡和其代谢物特异性的单克隆抗体

    公开(公告)号：US07195882B2

    公开(公告)日：2007-03-27

    申请号：US10453256

    申请日：2003-06-03

    申请人： Richard T. Root ,  Mitali Ghoshal

    发明人： Richard T. Root ,  Mitali Ghoshal

    IPC分类号： C01N33/535 ,  C01N33/533 ,  C07K16/44 ,  C07K17/06 ,  C07D451/00

    CPC分类号： G01N33/9486 ,  C07D498/12 ,  C07K16/44

    摘要： The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine metabolite conjugates for the production of monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof and hybridoma cells that produce the monoclonal antibodies. The invention also relates to immunoassay methods for determining buprenorphine and/or one or more buprenorphine metabolites in a sample using the novel antibodies and conjugates of the present invention.

    摘要翻译： 本发明涉及特异性结合丁丙诺啡和/或其至少一种代谢产物的单克隆抗体。 本发明还涉及用于产生特异性结合丁丙诺啡和/或其至少一种代谢产物的单克隆抗体的丁丙诺啡代谢物缀合物和产生单克隆抗体的杂交瘤细胞。 本发明还涉及使用本发明的新抗体和缀合物测定样品中丁丙诺啡和/或一种或多种丁丙诺非代谢物的免疫测定方法。

    Acylbenzoxazines for enhancing synaptic response
    9.
    发明授权
    Acylbenzoxazines for enhancing synaptic response 失效
    用于增强突触反应的酰基苯并恶嗪

    公开(公告)号：US6124278A

    公开(公告)日：2000-09-26

    申请号：US54916

    申请日：1998-04-03

    申请人： Gary A. Rogers ,  Peter Johnstrom

    发明人： Gary A. Rogers ,  Peter Johnstrom

    IPC分类号： A61K31/5365 ,  A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D498/12 ,  C07D498/14 ,  C07D498/04

    CPC分类号： C07D498/12 ,  C07D498/14

    摘要： Compounds based on the benzoxazine ring system that are remarkably more potent than corresponding benzoyl piperidines for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof, and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.

    摘要翻译： 公开了基于苯并恶嗪环体系的化合物，其相当于相应的苯甲酰哌啶用于增强由AMPA受体介导的突触反应的效力，其制备方法及其用于治疗患有神经或智力受损的受试者的方法 由于兴奋性突触数量或AMPA受体数量的不足而起作用。 本发明化合物还可用于治疗非受损受试者，以提高依赖于使用AMPA受体的脑网络和改善记忆编码的感觉运动和认知任务中的表现。