公开(公告)号：US12071632B2

公开(公告)日：2024-08-27

申请号：US17049916

申请日：2019-04-23

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Shirin Munir ,  Linda G. Brock ,  Ursula J. Buchholz ,  Peter L. Collins

IPC分类号： C12N15/86 ,  A61K39/155 ,  A61P31/14 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/155 ,  A61P31/14 ,  A61K2039/5256 ,  A61K2039/543 ,  C12N2760/18534 ,  C12N2760/18544 ,  C12N2760/18551

摘要： Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.